The titanium dioxide (TiO2) photocatalyst reactor is a widely used approach for eliminating non-biodegradable compounds in water and wastewater. Predicting the performance of the reactor in removing acid red 14 (AR14) was investigated using radial basis function (RBF), Adaptive Neuro-Fuzzy Inference System (ANFIS), and fuzzy regression analysis. The input variables in the models were radiation, irradiation time, the initial concentration of nanoparticle TiO2 to cement ratio (nTiO2/c), pH, initial concentration of AR14, flow rate, and initial concentration of oxidizing peroxydisulfate. In addition, for reducing the overfitting of the training process, we used K-fold cross-validation. The results of using the three methods indicated that the ANFIS performance was more suitable in comparison with the fuzzy regression models, such that the coefficient of determination (R2), index of agreement (IA), Nash–Sutcliffe efficiency (E) for model efficiency, Mean Squared Error (MSE), and Mean Bias Error (MBE) for training between the observed data and predicted data reached 0.965, 0.991, 0.73, 0.0132 and 0.019, respectively. Normalized input data improved slightly the training processes and performance of RBF compared with non-normalized input data. The ANFIS neural network for training process and model performance slightly achieved better results than the RBF neural network. The performance of the fuzzy regression approach was less suitable in comparison with RBF and ANFIS modeling. The sensitivity analysis of the RBF neural network depicted that the initial concentration of peroxydisulfate (S2O8) was the most effective factor (25.6%) in predicting the removal of AR14 from synthetic wastewater. After that, the effective factors were irradiation time (12.44%), initial concentration of AR14 (10.37%), pH (10.37), flow rate (8.55%), and the weight ratio of the initial concentration of nanoparticle TiO2 to cement ratio (nTiO2/c) (1.75%), respectively.
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