Sensitive Fiber Research Articles

Highly sensitive fiber optic enhanced Raman scattering sensor

Highly sensitive fiber optic enhanced Raman scattering sensor

Highly sensitive fiber grating hydrogen sensor based on hydrogen-doped Pt/WO3

Hydrogen sensors are key to the emerging clean hydrogen economies and fiber-optic hydrogen sensors play a unique role owing to their inherent safety and high sensitivity. Currently Pt/WO3 has been employed as the mainstream hydrogen-sensitive material in high performance hydrogen sensors. Here we develop an ultrasensitive fiber-optic hydrogen sensor with fast response by coating pretreated Pt/WO3 nanomaterial on fiber Bragg grating. We observe a great enhancement in sensitivity by the hydrogen-doping of the Pt/WO3 nanomaterials. The generation of HxWO3 composite material is confirmed by XRD, FTIR and Raman analysis. Compared with pure Pt/WO3, a 184-fold improvement in sensitivity is achieved by hydrogen doping, with a fast response of 25 s. An impressive limit of detection (LOD) of 30 ppm is demonstrated by employing both the narrowband weak FBGs and the hydrogen-doped Pt/WO3. The immunity to ambient temperature fluctuation is demonstrated by self-calibration through detecting the wavelength difference between a pair of FBGs. Good specificity is also demonstrated. This technology shows great potential in high spatial-resolution quasi-distributed hydrogen sensing.

A highly sensitive torsion sensor based on upright-inverted alternating triangular prism structure on the single-multi-single mode fiber

In this paper, a novel torsion sensor based on Mach-zehnder interferometer (MZI) is proposed and demonstrated. The proposed sensor is fabricated by the single-mode fiber (SMF) and multi-mode fiber (MMF) shear splicing, further employing CO2 laser to modulate the MMF surface into triangular prism form. And compare the number of different triangular prism pairs structure on torsion sensitivity. By increasing the number of triangular prism pairs effectively improve the torsion sensitivity. The experimental results show that in the range of 0–9.617 rad/m, the highest sensitivity fiber sensor can be obtained with a sensitivity of 3.3133 nm/(rad/m). Meanwhile, the temperature characteristic of the sensor is investigated, which presents a sensitivity of 21.67 pm/℃ in the range from 30 ℃ to 100 ℃. Therefore, the temperature crosstalk is 0.0065 (rad/m)/℃, which results in a low temperature crosstalk. In addition, the structure also has the advantages of low cost and simple manufacturing process.

High-sensitivity and directional-identification fiber magnetic field sensor via polarimetric fiber ring laser with a fiber Faraday rotator

A highly sensitive fiber magnetic field sensor with directional identification utilizing multi-longitudinal-mode fiber ring laser (FRL) based on polarization-mode beat frequency (PMBF) is experimentally demonstrated. A bismuth-doped iron garnet (BIG), as a kind of fiber Faraday rotator, is embedded in the FRL and serves as a fiber magnetic field probe, whose birefringence shows strong dependence on the external magnetic field due to magneto-optical Faraday effect, leading to the frequency drift of PMBF. Thus, the external magnetic field can be characterized by monitoring the change in a certain PMBF. Additionally, the drift direction of the tracked PMBF is closely related to the applied magnetic field direction, which is attributed to the non-reciprocity of Faraday magneto-optical rotation. Therefore, it shows the good ability to distinguish the applied forward (positive) and reverse (negative) magnetic field. The experimental results reveal that the tracked PMBF signal near 100 MHz has opposite frequency drift signs in the forward (positive) range of 0–20 mT and reverse (negative) range of 0 - −20 mT, which can be used to identify the axial orientation of the applied magnetic field. Additionally, it shows the maximum magnetic field sensitivities of −100.76 and −105.73 kHz/mT in the positive and negative magnetic field ranges, respectively. The designed device makes full use of the advantages of the fiber laser that rapidly demodulates the magnetic field with the help of high-speed digital processing technology, as well as fast response, high integration and low cost of fiber Faraday rotator, offering potentials in high-sensitivity magnetic field measurement in a confined space.

Effect of insulin insufficiency on ultrastructure and function in skeletal muscle.

Decreased insulin availability and high blood glucose levels, the hallmark features of poorly controlled diabetes, drive disease progression and are associated with decreased skeletal muscle mass. We have shown that mice with β-cell dysfunction and normal insulin sensitivity have decreased skeletal muscle mass. This project asks how insulin deficiency impacts on the structure and function of the remaining skeletal muscle in these animals. Skeletal muscle function was determined by measuring exercise capacity and specific muscle strength prior to and after insulin supplementation for 28days in 12-week-old mice with conditional β-cell deletion of the ATP binding cassette transporters ABCA1 and ABCG1 (β-DKO mice). Abca1 and Abcg1 floxed (fl/fl) mice were used as controls. RNAseq was used to quantify changes in transcripts in soleus and extensor digitorum longus muscles. Skeletal muscle and mitochondrial morphology were assessed by transmission electron microscopy. Myofibrillar Ca2+ sensitivity and maximum isometric single muscle fibre force were assessed using MyoRobot biomechatronics technology. RNA transcripts were significantly altered in β-DKO mice compared with fl/fl controls (32 in extensor digitorum longus and 412 in soleus). Exercise capacity and muscle strength were significantly decreased in β-DKO mice compared with fl/fl controls (P=0.012), and a loss of structural integrity was also observed in skeletal muscle from the β-DKO mice. Supplementation of β-DKO mice with insulin restored muscle integrity, strength and expression of 13 and 16 of the dysregulated transcripts in and extensor digitorum longus and soleus muscles, respectively. Insulin insufficiency due to β-cell dysfunction perturbs the structure and function of skeletal muscle. These adverse effects are rectified by insulin supplementation.

A highly sensitive diaphragm pressure sensor based on fiber Bragg grating with multiprobe configuration

The demand for accurate low-pressure sensing has become indispensable across diverse industries and research domains, where meticulous pressure monitoring holds paramount significance. This research work presents the development of a multiprobe extrinsically sensitive low pressure fiber Bragg grating (FBG) sensor. Three distinct diaphragm-based FBG sensing probes, equipped with silicone diaphragms of 0.5 mm, 1 mm, and 2 mm thickness, are developed within a unified assembly. This design offers the flexibility to select a probe based on the pressure magnitude and desired sensitivity and resolution. The displacement of diaphragm centers within the probes, caused by pressure variations in gas pipe channels, is actuated through an FBG-cantilever system. The sensor exhibits a dynamic range spanning 0 to 10 psi, featuring a peak sensitivity of 1.635 nm/psi. With a negligible hysteresis of 0.2 % observed in a complete operational cycle, the sensor demonstrates consistent stability across various constant pressure conditions, characterized by an average transient of <1 %. Furthermore, cyclic testing reveals an average deviation of 1.58 % in sensor response. This innovative sensor offers promising avenues for industrial applications and research and development endeavors that necessitate precise and reliable pressure measurements in the low pressure domains.

Cancer cell detection by plasmonic dual V-shaped PCF biosensor

In this paper, a highly sensitive plasmonic photonic crystal fiber (PCF) biosensor is reported for cancer cell detection. The modal analysis of the reported biosensor is performed using the full vectorial finite element method. The suggested PCF sensor has dual V-shaped groves to enhance the sensor sensitivity where two gold nano-rods are mounted on the etched surfaces. The main idea of the optical sensors is to track the electromagnetic coupling between the leaky core mode and the surface plasmon mode (SPM) at the metal/dielectric interface. When the SPM and one of the fundamental core modes are phase-matched, strong coupling occurs. Therefore, maximum confinement loss is achieved for the core-guided mode at the resonance wavelength, which depends on the analyte refractive index (RI). The V-shaped groove enhances the core/SPM coupling where high RI sensitivity of 24,000 nm/RIU is achieved along the RI range from 1.38 to 1.39, with a resolution of 2.703×10−6RIU. The potential of using the suggested RI sensor for cancer cell detection is then demonstrated. In this context, high sensitivities of 23,700 nm/RIU, 8,208 nm/RIU, and 14,428.6 are obtained for basal, cervical, and breast cancer cells with resolutions of 4.22×10−6RIU, 12.18×10−6RIU, and 6.93×10−6RIU, respectively. The achieved sensitivity and resolution are higher than those of the recently reported cancer biosensors. Moreover, the developed label-free biosensor is safer than other chemical and surgical techniques.

A New Treatment for Recalcitrant Neurotrophic Keratopathy of Ocular Graft-Versus-Host Disease with Virus Infection.

Neurotrophic keratopathy (NK) is a rare degenerative ocular disease that can be difficult to treat. There were no effective resolutive treatments for severe NK caused by ocular graft-versus-host disease (oGVHD) along with virus infection. To address this question, we designed a prospective cohort study to evaluate the efficacy and safety of topical recombinant human nerve growth factor (rhNGF) in patients with recalcitrant NK of oGVHD and viral infection. This prospective cohort study enrolled patients with recalcitrant NK diagnosed with oGVHD and treated with rhNGF. Clinical evaluations included the range of epithelial defects, best corrected visual acuity, intraocular pressure, slit-lamp examination, and corneal fluorescein staining. Examinations of the central corneal thickness, corneal sensitivity, and nerve fiber regeneration were performed at each visit at 4, 8, 12, 20weeks and 6months, respectively, after initiating rhNGF treatment. All enrolled patients were diagnosed with NK at stage2 (7 eyes, 63.6%) or stage3 (4 eyes, 36.4%) and responded to rhNGF treatment. Five of 11 (45.5%) and 9 of 11 eyes (81.8%) achieved complete corneal epithelial healing after 4 and 8weeks, respectively. All 11 eyes (100%) achieved complete corneal healing after 12weeks. There was also a significant reduction in the corneal ulcer area during each visit (P < 0.001), as well as in the corneal fluorescein staining score (P < 0.010). There was a significant improvement in corneal sensation when compared to the baseline (P < 0.050). Topical treatment with rhNGF effectively promoted the complete corneal healing of persistent epithelial defects and corneal ulcers in patients with recalcitrant NK in oGVHD and viral infection.

Cytokines profile in pure neural leprosy.

Pure Neural Leprosy (PNL) is a form of this long time known disease that affects only the peripheral nervous system. Since it is a rare form of the disease, its pathophisiology is still poorly understood. Describe the cytokines profile in patients with PNL. 30 Patients diagnosed with PNL in the Souza Araujo Outpatient Clinic and with cytokines evaluated were selected. They were evaluated by neurologists and diagnosed after a nerve biopsy. Serum levels of IL-1 β, IL-6, IL-10, IL-17, TNF, CCL-2/MCP-1, IFN-ϒ, CXCL-10/IP-10 and TGF-β were evaluates at the moment of the diagnosis. Neural thickening was a common clinical finding in this groups of patients. Small and medium sensitive fibers signs and symptoms were present in 92% of the patients and motor involvement in 53%. 43% of patients presented neuropathic pain and no one had neuritis TGF-beta, IL-17, CCl-2 and IP-10. CCL-2 levels were associated with demyelinating patters and IP-10 and IL-1o were associated with axonal patterns at NCS. PNL patients' cytokine profile appears to be different of other clinical forms of leprosy, with the presence of cytokines described in both tuberculoid and lepromatous leprosy. High levels of CCl-2 may be related to the presence of silent neuritis as well as the presence of IL-10. PNL is unique a form of leprosy, therefore, understanding its immunological profiles essential to better understand the disease itself.

Highly Sensitive Temperature Sensor Based on Vernier Effect Using a Sturdy Double-cavity Fiber Fabry-Perot Interferometer.

Temperature measuring is a daily procedure carried out worldwide in practically all environments of human activity, but it takes particular relevance in industrial, scientific, medical, and food processing and production areas. The characteristics and performance of the temperature sensors required for such a large universe of applications have opened the opportunity for a comprehensive range of technologies and architectures capable of fulfilling the sensitivity, resolution, dynamic range, and response time demanded. In this work, a highly sensitive fiber optic temperature sensor based on a double-cavity Fabry-Perot interferometer (DCFPI) is proposed and demonstrated. Taking advantage of the Vernier effect, we demonstrate that it is possible to improve the temperature sensitivity exhibited by the polymer-capped fiber Fabry-Perot interferometer (PCFPI) up to 39.8 nm/°C. The DCFPI is sturdy, reconfigured, and simple to fabricate, consisting of a semi-spherical polymer cap added to the surface of the ferrule of a commercial single-mode fiber connector (SMF FC/PC) placed in front of a mirror at a proper distance. The length of the air cavity (Lair) was adjusted to equal the thickness of the polymer cap (Lpol) plus a distance δ to generate the most convenient Vernier effect spectrum. The DCFPI was packaged in a machined, movable mount that allows the adjustment of the air cavity length easily but also protects the polymer cap and simplifies the manipulation of the sensor head.

A highly sensitive optical fiber sensor enables rapid triglycerides-specific detection and measurement at different temperatures using convolutional neural networks

For specific recognition and sensitive detection of triglycerides (TGs), an optical fiber sensor (OFS) based on an enhanced core diameter mismatch was proposed. The sensitivity of the sensor is significantly increased due to the repetitive excitation of the higher-order cladding modes. A technique for immobilizing lipase using covalent binding technology was presented and demonstrated by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy. The interference dip of the sensor was shifted due to TGs being hydrolyzed in the presence of lipase. The sensor shows an optimal response within 3 min and exhibits a high sensitivity of 0.9933 nm/(mg/ml) and a limit of detection of 0.0822 mg/ml in the concentration range 0–8 mg/ml at a temperature of 37 °C and a pH of 7.4. The response of the sensor to TGs concentration at different temperatures and pH was investigated. The reproducibility, reusability, and stability of the proposed sensor were tested and verified experimentally. The biosensor is highly specific for TGs and unaffected by many other interfering substances. Further, the measurement of TGs concentration at different temperatures was realized. This method provides a new way to detect TGs rapidly and reliably and has potential applications in medical research and clinical diagnosis.

Highly Sensitive Capacitive Fiber Pressure Sensors Enabled by Electrode and Dielectric Layer Regulation.

Capacitive pressure sensors play an important role in the field of flexible electronics. Despite significant advances in two-dimensional (2D) soft pressure sensors, one-dimensional (1D) fiber electronics are still struggling. Due to differences in structure, the theoretical research of 2D sensors has difficulty guiding the design of 1D sensors. The multiple response factors of 1D sensors and the capacitive response mechanism have not been explored. Fiber sensors urgently need a tailor-made theoretical research and development path. In this regard, we established a fiber pressure-sensing platform using a coaxial wet spinning process. Aiming at the two problems of the soft electrode modulus and dielectric layer thickness, the conclusions are drawn from three aspects: model analysis, experimental verification, and formula derivation. It makes up some theoretical blanks of capacitive fiber pressure sensors. Through the self-regulation of these two factors without a complex structural design, the sensitivity can be significantly improved. This provides a great reference for the design and development of fiber pressure sensors. Besides, taking advantage of the scalability and easy integration of 1D electronics, multipoint sensors prepared by fibers have verified their application potential in health monitoring, human-machine interface, and motion behavior analysis.

Care in family coping with teenagers who use drugs

Aim: Know the meanings and family coping of adolescents who consume drugs in rehabilitation. Method: Qualitative research with a phenomenological design sought to know the life stories of the families of adolescents who consume drugs in a rehabilitation center in the city of Chihuahua. Participant observation, field diary and in-depth interview were used, content analysis was carried out in three moments: discovery, coding and construction of units of meaning. Results: The consumption of addictive substances in an adolescent causes changes and feelings in family dynamics, generating helplessness, and anger and at the same time stress and fear. From the perspective of the coping experienced by the family of the adolescent who uses drugs, there are four categories: poor family communication; to us as a family who takes care of us; mother's intuition, an awakening to reality and finally defeat as a family. Conclusion: It is not easy to structure a form of care, it was necessary to reach the most sensitive fibers of the human being in order to understand the processes in which he is immersed, establishing an intimate and intentional dialogue with him, since he is surrounded by a whirlwind of pain and suffering.

High Sensitivity Fiber Optic Strain Sensor Based on CFBG-FPI and Vernier Effect

High Sensitivity Fiber Optic Strain Sensor Based on CFBG-FPI and Vernier Effect

Highly sensitive dual core photonic crystal fiber-based LSPR sensor with simultaneous multi-analyte detection of a wide refractive index range

This manuscript introduces an anisotropic highly sensitive dual core photonic crystal fiber sensor based on localized surface plasmon resonance, possessing the ability to detect multiple analytes simultaneously. Liquid analytes having a refractive index (RI) within the range of 1.25 to 1.5 RIU have been investigated using the proposed sensor. The numerical analysis of the sensing parameters for the proposed sensor shows a maximum wavelength sensitivity of 47,500 nm/RIU for x-polarization (Channel 1) and 18,050 nm/RIU for y-polarization (Channel 2), respectively using the wavelength interrogation technique. Maximum amplitude sensitivity of 625 RIU−1 and 437 RIU−1 is obtained for x−pol. and y−pol., respectively using the amplitude interrogation technique. Maximum sensor resolution of 2.11 × 10−6 RIU and 5.01 × 10−6 RIU is obtained for x−pol. and y−pol., respectively. The linear relationship of the resonant wavelength with the RI produces R2 = 0.9976 and R2 = 0.9979, corresponding to a degree (3) for x−pol. and y−pol., respectively. The figure of merit for x−pol. and y−pol. are 84 RIU−1 and 123 RIU−1.

Tapered Fiber Bioprobe Based on U-Shaped Fiber Transmission for Immunoassay.

In this paper, a tapered fiber bioprobe based on Mach-Zehnder interference (MZI) is proposed. To retain the highly sensitive straight-tapered fiber MZI sensing structure, we designed a U-shaped transmission fiber structure for the collection of optical sensing signals to achieve a miniature-insert-probe design. The spectrum responses from the conventional straight-tapered fiber MZI sensor and our proposed sensor were compared and analyzed, and experimental results showed that our proposed sensor not only has the same sensing capability as the straight-tapered fiber sensor, but also has the advantages of being flexible, convenient, and less liquid-consuming, which are attributed to the inserted probe design. The tapered fiber bioprobe obtained a sensitivity of 1611.27 nm/RIU in the refractive index detection range of 1.3326-1.3414. Finally, immunoassays for different concentrations of human immunoglobulin G were achieved with the tapered fiber bioprobe through surface functionalization, and the detection limit was 45 ng/mL. Our tapered fiber bioprobe has the insert-probe advantages of simpleness, convenience, and fast operation. Simultaneously, it is low-cost, highly sensitive, and has a low detection limit, which means it has potential applications in immunoassays and early medical diagnosis.

Highly sensitive twin core photonic crystal fiber for hazardous cancer cell detection in THz frequency regime

Highly sensitive twin core photonic crystal fiber for hazardous cancer cell detection in THz frequency regime

Ultracompact and Sensitive Fiber Michelson Temperature Sensor-Based Parallel Polymer Cavities With Vernier Effect

Ultracompact and Sensitive Fiber Michelson Temperature Sensor-Based Parallel Polymer Cavities With Vernier Effect

A highly sensitive strain fiber sensor based on waved core structure

Strain and temperature, as two important parameters to evaluate structural health, is increasingly paid numerous attentions for years. In this article, we developed and experimentally tested a highly sensitive strain sensor based on SMS structure with waved core multi-mode fiber (MMF), which has ability to monitor temperature simultaneously. By introducing a section of bent-core fiber into the portion of MMF, the higher-order cladding mode is excited to enhance the sensitivity. Furthermore, the portion of bent-core displays significant influence on effective refractive index (ERI) of the MMF section as strain applied, which brings about higher strain sensitivity. The experimental results display that the highest sensitivity of the sensor reaches 125.5 pm/με within 0–200 με and the measuring range achieves 0–1200 με. By demodulating two dips, simultaneous measurement for strain and temperature is achieved by solving the equation matrix. This simple method displays minor influence on mechanical property and enhances the strain sensitivity considerably. It is strongly believed the proposed sensor brings about a competitive choice in engineering fields.

High-sensitivity fiber SPR strain sensor based on n-type structure.

At present, fiber strain sensors are mainly of the grating type and interference type, while there is relatively little research on fiber surface plasmon resonance (SPR) strain sensors. In this Letter, we propose a highly sensitive fiber SPR strain sensor based on an n-type structure. The strain changes the shape of the fiber n-type structure, causing the transmission mode of light in the fiber to change, thereby changing the SPR incidence angle and causing the SPR resonance valley wavelength to shift, achieving highly sensitive SPR strain sensing. The test results indicate that the strain sensing sensitivity of the proposed sensor reaches 21.33 pm/µε, and two n-type structures are connected in series to obtain a double n-type structure, further enhancing the strain sensing sensitivity to 33.44 pm/µε. This fiber strain sensor has advantages of high sensitivity, low temperature cross talk, strong structural stability, and low production cost, and is expected to become a new solution for wearable intelligent monitoring equipment and strain sensors in the aerospace field.