Sensitive Array Research Articles

Cannonball or Bowling Ball: Proper Motion and Parallax for PSR J0002+6216

We report the results of careful astrometric measurements of the cannonball pulsar J0002+6216 carried out over 3 yr using the High Sensitivity Array. We significantly refine the proper motion to μ = 35.3 ± 0.6 mas yr−1 and place new constraints on the distance, with the overall effect of lowering the velocity and increasing the inferred age to 47.60 ± 0.80 kyr. Although the pulsar is brought more in line with the standard natal kick distribution, this new velocity has implications for the morphology of the pulsar wind nebula that surrounds it, the density of the interstellar medium through which it travels, and the age of the supernova remnant (CTB 1) from which it originates.

Olfactory visualization sensor based on densely connected convolutional networks for in-situ fruit ripeness prediction

The classification of ripeness levels is one of the most important indicators to assess fruit quality, and a technique to achieve in-situ ripening grading is urgently needed. We constructed an olfactory visualization sensor based on Pd2+-dye/NH2-UiO-66 as the gas-sensing materials and densely connected convolutional networks (DenseNet) as data classification method for in-situ fruit ripeness differentiation by ethylene detection. The designed Pd2+-dye/NH2-UiO-66 composites showed extremely sensitive sensing performance for C2H4 detection due to the high loading capacity for colorants (Pd2+ and dyes) and pre-concentration for C2H4. A series of Pd2+-dye/NH2-UiO-66 composites were synthesized using eight pH dyes with different pH sensitivity ranges, which were used to fabricate the colorimetric sensor arrays for C2H4 specific detection. Taking advantage of the greatly sensitive and specific nature of C2H4 detection, the colorimetric sensor arrays were applied for in-suit fruit ripeness classification by integrating DenseNet, achieving up to 99.91% classification accuracy. The combination of Pd2+-dye/NH2-UiO-66 composites based on highly sensitive and specific colorimetric sensor arrays and the supervised image classification method DenseNet enables high-precision prediction of different fruit ripeness and opens new possibilities in the low-cost and on-site classification of ripeness.

A colorimetric sensor array based on nanoceria crosslinked and heteroatom-doped graphene oxide nanoribbons for the detection and discrimination of multiple pesticides

Nanozymes have demonstrated high potential in constructing colorimetric sensor array for pesticides. However, rarely array for pesticides constructed without bio-enzyme were reported. Herein, nanoceria crosslinked graphene oxide nanoribbons (Ce-GONRs) and heteroatom-doped graphene oxide nanoribbons (Ce-BGONRs and Ce-NGONRs) were prepared, demonstrating excellent peroxidase-like activities. A colorimetric sensor array was developed based on directly inhibiting the peroxidase-like activities of the above three nanozymes, which realized the discrimination and quantitative analysis of six pesticides. In the presence of pesticides including carbaryl (Car), fluroxypyr-mepthyl (Flu), thiophanate-methyl (Thio), thiram (Thir), diafenthiuron (Dia) and fomesafen (Fom), the peroxidase-like activities of three nanozymes were inhibited to different degrees, resulting in different fingerprint responses. The six pesticides in the concentration range of 0.1–50 μg/mL and two pesticides mixtures at varied ratios could be detected and discriminated, and minimum detection limit for pesticides was 0.022 μg/mL. In addition, this sensor array has been successfully applied for pesticides discrimination in lake water and apple samples. This work provided a new strategy of constructing simple and sensitive colorimetric sensor array for pesticides based on directly inhibiting the catalytic activities of nanozymes.

Retracted: Estimation Method for Mixed Near-Field and Far-Field Sources Based on Four-Order Cumulant and Polarization Sensitive Array

Retracted: Estimation Method for Mixed Near-Field and Far-Field Sources Based on Four-Order Cumulant and Polarization Sensitive Array

Pulsar Discovery Prospect of FASTA

The Five-hundred-meter Aperture Spherical radio Telescope (FAST) has discovered more than 650 new pulsars, which account for 20% of our known Galactic pulsar population. In this paper, we estimate the prospect of a pulsar survey with a radio telescope array to be planned—the FAST Array (FASTA), consists of six “FAST-type” telescopes. Such a sensitive radio telescope array would be a powerful instrument in probing the pulsar population deep into our Galaxy as well as in nearby galaxies. We simulate the FASTA pulsar discovery prospects with different Galactic pulsar population models and instrumental parameter combinations. We find that FASTA could detect tens of thousands of canonical pulsars and well-over thousands of millisecond pulsars. We also estimate the potential yield if the FASTA is used to search for pulsars from the nearby spiral galaxy M31, and find that it would probably discover around a hundred new radio pulsars.

Low-Complexity DOA Estimation via Synthetic Coprime Polarization Sensitive Array with Reduced Mutual Coupling in Nonuniform Noise

Low-Complexity DOA Estimation via Synthetic Coprime Polarization Sensitive Array with Reduced Mutual Coupling in Nonuniform Noise

Serum Neurofilament light chain (NfL) levels in children with and without neurologic diseases.

Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal damage. Elevated sNfL levels have been reported in numerous neurologic diseases in adults, whereas data on sNfL in the pediatric population are incomplete. The aim of this study was to investigate sNfL levels in children with various acute and chronic neurologic disorders and describe the age dependence of sNfL from infancy to adolescence. The total study cohort of this prospective cross-sectional study consisted of 222 children aged from 0 to 17 years. Patients' clinical data were reviewed and patients were assigned to the following groups: 101 (45.5%) controls, 34 (15.3%) febrile controls, 23 (10.4%) acute neurologic conditions (meningitis, facial nerve palsy, traumatic brain injury, or shunt dysfunction in hydrocephalus), 37 (16.7%) febrile seizures, 6 (2.7%) epileptic seizures, 18 (8.1%) chronic neurologic conditions (autism, cerebral palsy, inborn mitochondrial disorder, intracranial hypertension, spina bifida, or chromosomal abnormalities), and 3 (1.4%) severe systemic disease. sNfL levels were measured using a sensitive single-molecule array assay. There were no significant differences in sNfL levels between controls, febrile controls, febrile seizures, epileptic seizures, acute neurologic conditions, and chronic neurologic conditions. In children with severe systemic disorders, by far the highest NfL levels were found with an sNfL of 429pg/ml in a patient with neuroblastoma, 126pg/ml in a patient with cranial nerve palsy and pharyngeal Burkitt's lymphoma, and 42pg/ml in a child with renal transplant rejection. The relationship between sNfL and age could be described by a second order polynomial with an R2 of 0.153 with a decrease of sNfL by 3.2% per year from birth to age 12 years and thereafter an increase by 2.7% per year until age 18 years. In this study cohort, sNfL levels were not elevated in children with febrile or epileptic seizures, or various other neurologic diseases. Strikingly high sNfL levels were detected in children with oncologic disease or transplant rejection. A biphasic sNfL age-dependency was documented, with highest levels in infancy and late adolescence and the lowest levels in middle school age.

High-sensitivity Observations of the H2O Megamasers of NGC 1068: Precise Astrometry and Detailed Kinematics

We present High Sensitivity Array observations of the H2O megamasers of NGC 1068. We obtain absolute astrometry with 0.3 mas precision that confirms the association of the disk masers with the nuclear radio continuum source S1. The new observations reveal two new blueshifted groups of disk masers. We also detect the 22 GHz continuum on short interferometric baselines. The position–velocity diagram of the disk masers shows a curve consistent with a nonaxisymmetric distribution of maser spots. This curve is probably the result of spiral arms with a constant pitch angle ∼5°. The disk kinematics are consistent with Keplerian rotation and low turbulent speeds. The inferred central mass is 17 × 106 M ☉. On the basis of disk stability arguments, the mass of the molecular disk is ≈110 × 103 M ☉. The disk masers further resolve into filamentary structures suggesting an ordered magnetic field threading the maser disk. The magnetic field strengths must be ≳2 mG to withstand turbulent motions in the partially ionized molecular gas. We note apparent asymmetries in the molecular disk that might be explained by anisotropic heating by a misaligned inner accretion disk. The new observations also detect the fainter jet masers north of the disk masers. The distribution and kinematics of the jet masers are consistent with an expanding ring of molecular gas.

Retraction: Highly Sensitive MoS2 Humidity Sensors Array for Noncontact Sensation.

Retraction: Highly Sensitive MoS2 Humidity Sensors Array for Noncontact Sensation.

Parameter Estimation and Mutual Coupling Self-Calibration with Orthogonal Polarization Sensitive Array

In order to address the mutual coupling impact with orthogonal polarization sensitive array, the mutual coupling self-calibration strategy is suggested in this study. Firstly, the mutual coupling properties are used to modify the steering vector of the array. By transforming the matrices, the properties of the polarization and direction-of-arrival (DOA) are isolated from the mutual coupling coefficients. Then, using the rank deficit matrix approach, the estimated the polarization properties and DOA values of the incoming signal are ascertained. The eigendecomposition of the transition matrix utilizing the modulus restrictions is then used to get the mutual coupling coefficient. The technique may be used to produce high-precision results of the mutual coupling coefficient when there is a substantial gap in the power of the signal sources. The outcomes of the simulation demonstrate the viability of the advanced method used in this work.

Improved Charge Transfer for NO2 Gas Sensors by Using 0D SnS Quantum Dot/2D WSe2 Heterostructures

A highly sensitive array of two-dimensional (2D) WSe2 nanosheets integrated with zero-dimensional (0D) SnS quantum dots was synthesized by combining liquid-phase exfoliation and wet chemical synthesis methods. The characterization results of scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD) revealed the formation of WSe2/SnS heterostructures, which enable a cyclic and reproducible high gas sensing response. The role allocation of SnS on WSe2 was verified by using density functional theory (DFT) calculations. The result indicates that the top alignment of SnS and the bottom layer of WSe2 act as a gas adsorption layer and carrier conduction layer, respectively. The charge interactions of the heterostructures were systematically explored by monitoring changes in the transferred characteristics at room temperature (27 °C) after introducing 25–100 ppb NO2. The highest sensing response of WSe2/SnS heterostructures toward the NO2 gas was found to be 1.08 at 25 ppb with a LOD of 10.6 ppb. The experimental and simulation results revealed that the charge transfer across the active sites increased after incorporating SnS in the WSe2. The sensing results showed an abrupt and reliable gas response under periodic NO2 gas injection unambiguously achieved by such heterostructures. The sensor also exhibited satisfactory stability and accuracy in selectivity and is not affected by humidity at room temperature. DFT calculations were also used to explain the sensing mechanism and heterojunction for such nanocomposites.

Multiple accurate and sensitive arrays for Capripoxvirus (CaPV) differentiation

Capripoxvirus (CaPV) contains three viruses that have caused massive losses in the livestock and dairy industries. Accurate CaPV differentiation has far-reaching implications for effectively controlling outbreaks. However, it has a great challenge to distinguishing three viruses due to high homology of 97%. Here, we established a sensitive CRISPR/Cas12a array based on Multiple-recombinase polymerase amplification (M-RPA) for CaPV differentiation, which provided a more comprehensive and accurate differentiation mode targeting VARV B22R and RPO30 genes. By sensitive CRISPR/Cas12a and M-RPA, the actual detection limits of three viruses were as low as 50, 40 and 60 copies, respectively. Moreover, Lateral flow dipstick (LFD) array based on CRISPR/Cas12a achieved portable and intuitive detection, making it suitable for point-of-care testing. Therefore, CRISPR/Cas12a array and LFD array paved the way for CaPV differentiation in practice. Additionally, we constructed a real-time quantitative PCR (qPCR) array to fill the qPCR technical gap in differentiation and to facilitate the quarantine departments.

Fluorescence sensor array of a multiplexing probe with three/four excitations/emissions for rapid and highly sensitive discrimination of foodborne pathogenic bacteria

Development of sensitive, accurate yet simplified fluorescence sensor array is crucial for rapid, multi-bacterial, on-site sensing applications. A fluorescence sensor array based on a multiplexing fluorescence probe (MFP, excitations/emissions with 278 nm/558 nm, 290 nm/364 nm, 362 nm/592 and 616 nm) was constructed. The positive MFP equipped with rich quinoline and pyridine groups can combine with the negative charge groups and electron-rich groups of bacterial surfaces, which causes the symbolic signal response in the sensing channels (four emissions and three excitations). The sensor array displayed sensitive response to bacteria even at a lower level (102 cfu mL−1) and high identification accuracy (100%) for drug-resistant bacteria, inactivated bacteria, and blends of bacteria. Furthermore, the developed sensor array demonstrated a high-throughput bacterial identification (92.1% accuracy) in real samples (pork and milk) with high sensitivity, rapid response, easy-to-operate, and independence of specific recognition elements, which would brighten the development of fluorescence sensor array.

Micro-Quartz Crystal Tuning Fork-Based Photodetector Array for Trace Gas Detection.

In this paper, a micro-quartz crystal tuning fork (M-QCTF) was first demonstrated for developing a low-cost, highly sensitive quartz tuning fork photodetector array for spectroscopic applications. A gas sensing system based on the M-QCTF photodetector and highly sensitive wavelength modulation spectroscopy was developed. Typically, an atmospheric greenhouse gas methane (CH4) molecule was selected as the target analyte for evaluating the M-QCTF and standard commercial QCTF detectivity. The results indicate that the M-QCTF photodetector exhibits ∼3.3 times sensitivity enhancement compared to the standard commercial QCTF. The long-term stability was evaluated by using the Allan deviation analysis method; a minimum detection limit of 1.2 ppm was achieved with an optimal integration time of 85 s, and the corresponding normalized noise equivalent absorption coefficient was calculated to be 4.45 × 10-10 cm-1 W/√Hz. Finally, a two-M-QCTF array detection scheme was experimentally demonstrated, and a signal-to-noise ratio enhancement factor of more than 1.7 times compared to that achieved using a single M-QCTF photodetector was realized, which proves a great potential for developing ultra-sensitive quartz tuning fork photodetector arrays for various applications.

Experimental characterization of a planar phase-engineered metamaterial lenslet for millimeter astronomy.

To unveil presently inscrutable details of the origins of our universe imprinted in the cosmic microwave background, future experiments in the millimeter and submillimeter range are focusing on the detection of fine features, which necessitate large and sensitive detector arrays to enable multichroic mapping of the sky. Currently, various approaches for coupling light to such detectors are under investigation, namely, coherently summed hierarchical arrays, platelet horns, and antenna-coupled planar lenslets. The last option offers increased bandwidth and a simpler fabrication while maintaining the desired optical performance. In this work, the design, fabrication, and experimental characterization of a prototype planar metamaterial phase-engineered lenslet operating in W-band [75GHz; 110GHz] is presented. Its radiated field, initially modeled and measured on a systematics-limited optical bench, is compared against a simulated hyperhemispherical lenslet, a more established technology. It is reported here that our device reaches the cosmic microwave background (CMB) specification for the next stages of experiments, demonstrating power coupling above 95% and beam Gaussicity above 97% while maintaining ellipticity below 10% and a cross-polarization level below -21d B through its operating bandwidth. Such results underline the potential advantages our lenslet can offer as focal optics for future CMB experiments.

Ganglioside-focused Glycan Array Reveals Abnormal Anti-GD1b Auto-antibody in Plasma of Preclinical Huntington’s Disease

Huntington's disease (HD) is a progressive and devastating neurodegenerative disease marked by inheritable CAG nucleotide expansion. For offspring of HD patients carrying abnormal CAG expansion, biomarkers that predict disease onset are crucially important but still lacking. Alteration of brain ganglioside patterns has been observed in the pathology of patients carrying HD. Here, by using a novel and sensitive ganglioside-focused glycan array, we examined the potential of anti-glycan auto-antibodies for HD. In this study, we collected plasma from 97 participants including 42 control (NC), 16 pre-manifest HD (pre-HD), and 39 HD cases and measured the anti-glycan auto-antibodies by a novel ganglioside-focused glycan array. The association between plasma anti-glycan auto-antibodies and disease progression was analyzed using univariate and multivariate logistic regression. The disease-predictive capacity of anti-glycan auto-antibodies was further investigated by receiver operating characteristic (ROC) analysis. We found that anti-glycan auto-antibodies were generally higher in the pre-HD group when compared to the NC and HD groups. Specifically, anti-GD1b auto-antibody demonstrated the potential for distinguishing between pre-HD and control groups. Moreover, in combination with age and the number of CAG repeat, the level of anti-GD1b antibody showed excellent predictability with an area under the ROC curve (AUC) of 0.95 to discriminate between pre-HD carriers and HD patients. With glycan array technology, this study demonstrated abnormal auto-antibody responses that showed temporal changes from pre-HD to HD.

Expanding Sgr A* dynamical imaging capabilities with an African extension to the Event Horizon Telescope

Context. The Event Horizon Telescope (EHT) has recently published the first images of the supermassive black hole at the center of our Galaxy, Sagittarius A* (Sgr A*). Imaging Sgr A* is plagued by two major challenges: variability on short (approximately minutes) timescales and interstellar scattering along our line of sight. While the scattering is well studied, the source variability continues to push the limits of current imaging algorithms. In particular, movie reconstructions are hindered by the sparse and time-variable coverage of the array. Aims. In this paper, we study the impact of the planned Africa Millimetre Telescope (AMT, in Namibia) and Canary Islands telescope (CNI) additions to the time-dependent coverage and imaging fidelity of the EHT array. This African array addition to the EHT further increases the eastwest (u, v) coverage and provides a wider time window to perform high-fidelity movie reconstructions of Sgr A*. Methods. We generated synthetic observations of Sgr A*’s accretion flow and used dynamical imaging techniques to create movie reconstructions of the source. To test the fidelity of our results, we used one general-relativistic magneto-hydrodynamic model of the accretion flow and jet to represent the quiescent state and one semi-analytic model of an orbiting hotspot to represent the flaring state. Results. We found that the addition of the AMT alone offers a significant increase in the (u, v) coverage, leading to robust averaged images during the first hours of the observating track. Moreover, we show that the combination of two telescopes on the African continent, in Namibia and in the Canary Islands, produces a very sensitive array to reconstruct the variability of Sgr A* on horizon scales. Conclusions. We conclude that the African expansion to the EHT increases the fidelity of high-resolution movie reconstructions of Sgr A* to study gas dynamics near the event horizon.

Searching Lorentz invariance violation from cosmic photon attenuation

Lorentz invariance violation (LIV) can change the threshold behavior predicted by special relativity and cause threshold anomalies which affect the propagation of cosmic photons. In this work, we focus on the threshold anomaly effect on cosmic photon attenuations by extragalactic background light (EBL) and discuss how to identify LIV from observations of very high energy (VHE) photons propagated from long distance in the universe. We point out that the Large High Altitude Air Shower Observatory (LHAASO), one of the most sensitive gamma-ray detector arrays currently operating at TeV and PeV energies, is an ideal facility for performing such LIV searching. We apply the proposed strategy to discuss the newly observed gamma-ray burst GRB 221009A to demonstrate the predictive ability of our suggestions.

Abstract PD5-08: PD5-08 Drug target activation mapping of matched triple negative primary and axillary lymph node metastases identifies and links the ER-AR-GR steroid hormone receptor axis with downstream AKT activation

Abstract Title: Drug target activation mapping of matched triple negative primary and axillary LN metastases identifies and links the ER-AR-GR steroid hormone receptor axis with downstream AKT activation Background: Triple negative breast cancer (TNBC) is comprised of heterogeneous subtypes that arise from various molecular alterations that result in TNBC having the poorest overall prognosis. There is growing interest in more sensitive ways to measure estrogen receptor (ER) and HER2 levels in the ER “negative” and HER2 “low/negative” settings, as there are patients with TNBC whose tumors are actually ER and/or HER2 “expressing/active”, and who may benefit from ER- and/or HER2-targeted therapies. Given the limitations of IHC in reliably quantitating ER and HER2 in low (0-1+) expressing tumors, we utilized highly sensitive reverse phase protein array (RPPA) to quantitate expression of these therapeutic targets along with downstream signaling activation mapping in a unique pilot set of patient-matched primary (P) and axillary lymph node (LN) metastases obtained synchronously. The quantitative expression of steroid hormone receptor expression/activation (ER, glucocorticoid receptor (GR), androgen receptor (AR)) along with their signaling architecture and dynamics were analyzed. Methods: A 12 P-LN paired tumor set was chosen for analysis (N=24). Manual macrodissection was used to enrich for tumor epithelium prior to RPPA analysis that quantitatively measured 155 proteins/phosphoprotein drug targets in key signaling pathways known to be involved in steroid hormone receptor biology and tumorigenesis. Statistical analysis using paired sample t-testing or Wilcoxon rank testing was performed (p< 0.05 uncorrected). Results: Protein pathway activation mapping and unsupervised clustering analysis revealed a subset of TNBCs from 3 of the 12 (25%) patients (N=4: 1 LN and 1 P, and one patient-matched LN and P) that was characterized by high relative levels of total ER. Interestingly, these same tumors also had amongst the highest relative levels of both total AR and activated (phosphorylated) GR compared to the rest of the 20 tumor samples. Downstream signaling analysis found significant (p< 0.05) activation/phosphorylation of AKT (S473 and/or T308) associated with the ER-AR-GR/steroid hormone activated/”high” TNBC signature compared to the 20 tumors that were steroid hormone “low”. Conclusions: Functional protein pathway activation mapping of a unique study set of synchronously obtained TNBC primary and LN metastasis revealed a steroid hormone receptor expression/activation signature of co-incidentally activated/expressed ER, GR and AR, that was also characterized by increased AKT activation (p< 0.05). This steroid hormone receptor “activated” signature was not observed to be significantly differentially expressed in LN compared to P tissues in cohort or matched pair analysis, suggesting that this signature may be present as an intrinsic event in the P, and not acquired in LN metastases. Recent data from stage I-III TNBC patients treated in the neoadjuvant setting with an AKT inhibitor1 revealed that responding TNBC patients had pre-treatment tumor biopsies that were enriched for both high AR expression and high phosphoAKT (S473 and/or T308) levels. If these observations that a subset of TNBCs are steroid hormone receptor “activated” despite being ER “negative” are confirmed in larger study sets, we hypothesize that this subgroup, identified by RPPA analysis of both P and LN metastases, could be potentially sensitive to AKT inhibition in combination with agents that target steroid hormone receptors. 1Shi Z, et al. Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer. Clin Cancer Res. 2022 Mar 1;28(5):993-1003 Citation Format: Julia Wulfkuhle, Page Blas, Heather Williams, Claudius Mueller, Rosa I. Gallagher, Mariaelena Pierobon, Joyce O’Shaughnessy, Emanuel F. Petricoin. PD5-08 Drug target activation mapping of matched triple negative primary and axillary lymph node metastases identifies and links the ER-AR-GR steroid hormone receptor axis with downstream AKT activation [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr PD5-08.

Elevated serum levels of glial fibrillary acidic protein are associated with covert hepatic encephalopathy in patients with cirrhosis

Blood biomarkers facilitating the diagnosis of covert hepatic encephalopathy (CHE) in patients with cirrhosis are lacking. Astrocyte swelling is a major component of hepatic encephalopathy. Thus, we hypothesised that glial fibrillary acidic protein (GFAP), the major intermediate filament of astrocytes, might facilitate early diagnosis and management. This study aimed to investigate the utility of serum GFAP (sGFAP) levels as a biomarker of CHE. In this bicentric study, 135 patients with cirrhosis, 21 patients with ongoing harmful alcohol use and cirrhosis, and 15 healthy controls were recruited. CHE was diagnosed using psychometric hepatic encephalopathy score. sGFAP levels were measured using a highly sensitive single-molecule array (SiMoA) immunoassay. In total, 50 (37%) people presented with CHE at study inclusion. Participants with CHE displayed significantly higher sGFAP levels than those without CHE (median sGFAP, 163pg/ml [IQR 136; 268] vs. 106pg/ml [IQR 75; 153]; p <0.001) or healthy controls (p <0.001). sGFAP correlated with results in psychometric hepatic encephalopathy score (Spearman's ρ=-0.326, p <0.001), model for end-stage liver disease score (Spearman's ρ= 0.253, p= 0.003), ammonia (Spearman's ρ= 0.453, p= 0.002), and IL-6 serum levels (Spearman's ρ= 0.323, p= 0.006). Additionally, sGFAP levels were independently associated with the presence of CHE in multivariable logistic regression analysis (odds ratio 1.009; 95% CI 1.004-1.015; p <0.001). sGFAP levels did not differ between patients with alcohol-related cirrhosis vs. patients with non-alcohol-related cirrhosis or between patients with ongoing alcohol use vs. patients with discontinued alcohol use.Conclusions: sGFAP levels are associated with CHE in patients with cirrhosis. These results suggest that astrocyte injury may already occur in patients with cirrhosis and subclinical cognitive deficits and that sGFAP could be explored as a novel biomarker. Blood biomarkers facilitating the diagnosis of covert hepatic encephalopathy (CHE) in patients with cirrhosis are lacking. In this study, we were able to demonstrate that sGFAP levels are associated with CHE in patients with cirrhosis. These results suggest that astrocyte injury may already occur in patients with cirrhosis and subclinical cognitive deficits and that sGFAP could be explored as a novel biomarker.