General analytic expressions for the total absorption coefficient of strong electromagnetic waves caused by confined electrons in Infinite semi-parabolic plus Semi-inverse Squared Quantum Wells (ISPSISQW) are obtained by using the quantum kinetic equation for electrons in the case of electron-optical phonon scattering. A second-order multi-photon process is included in the result. The dependence of the total absorption coefficient on the intensity E0, the photon energy ħΩ of an SEMW, and the temperature T for a specific GaAs/GaAsAl ISPPSISQW is achieved by using a numerical method. The computational results demonstrate that the total absorption coefficient’s dependence on photon energy can be utilized for optically detecting the electric sub-bands in an ISPPSISQW. Besides, we also give theoretical rules on the dependence of the Full Width at Half Maximum on important external parameters such as temperature and perpendicular magnetic field. Furthermore, the obtained results are consistent with prior theoretical and experimental findings.