The dynamics of partons and hadrons in ultra-relativistic nucleus-nucleus collisions is analyzed within the Parton-Hadron-String Dynamics (PHSD) transport approach, which is based on a dynamical quasiparticle model for the partonic phase (DQPM) including a dynamical hadronization scheme while reproducing lattice QCD results in thermodynamic equilibrium for the equation-of-state as well as transport coefficients like shear and bulk viscosities, the electric conductivity or the charm diffusion coefficient of the hot QCD medium. In this contribution we report on the recent results on the charm dynamics and elliptic flow in Au+Au collisions at RHIC and Pb+Pb reactions at the LHC as well as on the single electron spectra from D— and B—meson semileptonic decays in Au+Au collisions at √sNN =200 and 62.4 GeV. We find that the PHSD approach well describes the Raa and elliptic flow v2 of open charm mesons in Au+Au collisions at √sNN = 200 GeV (from STAR) and 2.76 TeV (from ALICE) as well as the elliptic flow of single electrons at √sNN = 200 and 62.4 GeV (from PHENIX), however, the large Raa at √sNN = 62.4 GeV is not reproduced at all which might indicate a new ’PHENIX puzzle’.