Thermal runaway in Li-ion cells and battery packs remains a topic of much importance for ensuring the safety of electrochemical energy conversion and storage systems. Thermal runaway also indirectly affects performance, as conservative overdesign to reduce the risk of thermal runaway affects system-level performance metrics such as energy storage density. Given the considerable challenges in experimental investigation of thermal runaway, theoretical models to predict thermal runaway characteristics of a cell or battery pack are critically needed. Such models can help guide the design of experiments, and ensure that practical systems are reasonably safe without being needlessly overdesigned.This talk will summarize ongoing work on theoretical analysis of multilayer diffusion-reaction heat transfer problems for predicting thermal runaway in Li-ion cells and battery packs. Following a linearization of heat generation terms, the governing energy conservation equation is solved in a multilayer geometry representative of a Li-ion cell comprising multiple electrode and separator layers, or of a battery pack containing several cells. It is mathematically shown that under certain conditions, this problem may admit a finite number of imaginary eigenvalues, which are shown to cause thermal runaway. It is shown that the occurrence of imaginary eigenvalues is governed by a delicate balance between heat generation, thermal conduction within the multilayer body and heat removal from the boundaries, based on which, an explicit threshold condition for thermal runaway is derived. This threshold condition is interpreted in the context of parameter values relevant to Li-ion cells. For example, it is shown that boundary cooling is severely limited in its role to prevent thermal runaway, whereas improving thermal transport within the cell is likely to be a lot more effective. This theoretical model is also extended to a two-layer problem comprising a finite layer adjoined by a semi-infinite body that may model immersion cooling of a Li-ion cell or battery pack. It is shown that while this diffusion-reaction problem is, in principle, unconditionally unstable, the finite time period of any discharge process may allow the temperature field to still remain within a safe envelope, if designed appropriately. Based on this mathematical model, scenarios related to immersion cooling of pouch cells are investigated.The theoretical work described in this talk is broadly relevant to several diffusion-reaction systems. In the particular context of Li-ion cells, these results may form the foundation of techniques to proactively predict and prevent thermal runaway in Li-ion cells and battery packs.