PurposeTo perform a review of research, funding, and clinical translation efforts for extracellular vesicles (EVs) within vision science. DesignRetrospective analysis of publication, funding, and clinical trials data. MethodsA pre-trained large language model (Jina2) was used to create semantic embeddings for 41,282 abstracts from articles related to extracellular vesicles archived on EMBASE and published between January 1966 and January 2024. The articles were projected and clustered according to semantic embedding similarity, and research subdomains for extracellular vesicles were determined through inspection of tf-idf weighted word clouds. Mann-Kendall trend analysis was performed to identify current areas of growth within extracellular vesicle research. Additionally, NIH funding data from RePORTER and clinical trials data from ClinicalTrials.gov were analyzed to correlate publication trends with funding support and clinical translation efforts. ResultsUnsupervised clustering and Mann-Kendall trend analysis identified wound healing/regeneration (p=0.030) and neurodegenerative disease (p=0.049) as significantly accelerating in growth of publication over time. Ophthalmology-restricted subset analysis identified that publications in age-related macular degeneration (p=0.191) and clinical applications (p=0.086) are no longer growing at a significant rate. Analysis of funding data identified that the NCI was the top funding institution overall, but that the NIA is rapidly advancing in terms of funding extracellular vesicle research and trials. Analysis of ClinicalTrials.gov data highlights a dearth of clinical trials within ophthalmology despite a growing number of studies in other medical subfields. ConclusionsExtracellular vesicles (EVs) remain a promising substrate for both the identification and treatment of vision-threatening diseases. A better understanding of the current landscape of research and funding trends should help to inform future funding and translational efforts.