PURPOSE: The aim of this study was to examine differences in training load, exertional and affective responses during self-selected and prescribed intensity bouts of resistance exercises in sedentary men. METHODS: Twenty-two participants (age 35.8 ± 5.8 yr; body mass, 81.1 ± 8.7 kg; BMI, 25.5 ± 2.6 kg·m-2), completed an orientation session, one maximal repetition (1RM) testing session, and two experimental trials of resistance exercise bouts at self-selected and prescribed-intensity, which were completed in a counterbalanced order. In the experimental trials, participants performed seven different exercises in using the following order: 1) chest press machine, 2) leg press machine, 3) seated machine rows, 4) seated machine leg extension, 5) seated machine overhead press, 6) seated machine biceps curl, and 7) standing cable triceps extension exercises. In the prescribed-intensity trial, three sets of 10 repetitions of each exercise were performed at 75% of his individual 1RM, whereas in the self-selected intensity subjects were permitted to self-select the load for each set and exercise. Perceived exertion (OMNI-RPE Scale), affective valence (Feeling Scale, Hardy & Rejeski, 1989) and training load (%1RM) of each set and exercise were recorded as the outcome variables. RESULTS: Results of 2 (self-selected vs prescribed-intensity) X 3 (sets) repeated measures multivariate analyses of variance revealed that, at self-selected condition, participants chose a lower exercise load (55.2 ± 3.4% vs 75% of 1RM), had a lower perceived exertion (5.8 ± 1.1 vs 8.5 ± 1.7), and a more pleasant affective response (0.8 ± 0.3 vs -1.2 ± 0.5) compared to an prescribed-intensity condition (p < 0.05). CONCLUSIONS: These findings demonstrate that the training load, perceived exertion, and affective response of self-selected exercises condition differ from prescribed-intensity condition. If the main goal is to increase adherence, a self-selected intensity can promote a more pleasant affective response, which may hopefully lead to a positive memory of the activity, increasing motivation for future physical activity behavior, and thus improving exercise adherence.