Background: Social exclusion is a particularly poignant and impairing social experience that can lead to affective and cognitive impairments in clinical populations. Various psychiatric disorders, (e.g., depression, social anxiety, and schizophrenia) are associated with hyper-responsivity to social exclusion. Social exclusion is exceedingly common in schizophrenia (e.g., most have very few friends, few get married, and many are estranged from family members). The most extensively validated paradigm for social exclusion is the Cyberball task, in which participants believe they are interacting with peers, and being excluded from an online ball-tossing game. For individuals with depression and anxiety, social exclusion leads to slowed processing speed, deficits in social self-regulation, and impaired cognitive control, memory, attention, and motivation. Despite the relevance to schizophrenia, no studies have examined the cognitive consequences of social exclusion in individuals with schizophrenia. Methods: Data collection is ongoing, and data are available on 35 patients with schizophrenia and 20 healthy controls. Social exclusion and social inclusion conditions were counterbalanced such that all participants were administered the Cyberball game (exclusion condition) and an online ball-passing game (inclusion condition) during 2 separate visits to our laboratory. Additionally, participants completed measures of neurocognition, defeatist beliefs, and emotional reactivity following both social exclusion and social inclusion. Results: There was a significant interaction such that the 2 groups showed different patterns in neurocognitive performance following social exclusion—patients get worse after being excluded and were less able to perform tasks requiring working memory and processing speed, while controls’ performance actually improved after they are socially excluded, compared to when they are included. Results indicate that patients had significantly higher levels of defeatist beliefs than controls, and both groups showed a significant increase in defeatist beliefs after social exclusion, compared to inclusion. Conclusion: This is the first study to directly examine the consequences of social exclusion on individuals with schizophrenia. The results suggest that individuals with schizophrenia may experience increases in neurocognitive impairment and in defeatist beliefs, when they feel socially excluded. The present data support the notion that social and environmental factors may contribute to impaired neurocognitive functioning in schizophrenia.
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