Introduction: We present a 34 year-old man with childhood hydrocephalus from presumed brain tumor, corrected with a shunt, motivated for TMS for cognitive enhancement of self-perceived difficulties with complex tasks, documented executive dysfunction on psychometric testing, and feeling easily overwhelmed. He was neither depressed nor anxious. Method: Treatment parameters were based on a PubMed search for “transcranial magnetic stimulation” and “cognitive enhancement.” NeuroStar was used to administer 20 sessions of daily left dorsolateral prefrontal cortex (DLPFC) stimulation at 10 Hz, 100% of motor threshold (MT), and 3,000 pulses, followed by 10 sessions of right DLPFC (10 Hz, 120% MT, 3,000 pulses). The 46-item Frontal Systems Behavior Scale (FrSBe), with subscales for Apathy, Disinhibition, and Executive Dysfunction, was completed at baseline and post-treatment by patient and his mother. Normalized T-scores were used to assess for clinically significant change (>10 points). Results: High frequency left DLPFC was the most common target for cognitive enhancement. FrSBe ratings by patient’s mother were significantly low at baseline and within the average range post-treatment. Patient’s self-ratings produced T-scores which ranged from average to significantly elevated at both baseline and completion of treatment. Patient noted a few hours of “clarity” during one of the early sessions but no other subjective improvement. Conclusions: Using TMS for cognitive enhancement has little supporting data. Our patient did not show any clear change in self-ratings of his behavior over the course of treatment, while his mother seemed to discount any behavioral changes at baseline, but seemed to have some limited acknowledgement of challenges after treatment, perhaps reflecting the focus of treatment on these same challenges leading to a more accurate appraisal. When symptoms cannot be clearly defined, observed, and measured, we are “chasing shadows.” Conflicts of interest: None Funding source: NoneTabled 1FrSBe- Patient Rating FormBaseline (12/20/2019)Post-treatment (1/27/2020)Apathy T-score:6769Disinhibition T-score:5658Executive Dysfunction T-score:7061FrSBe- Family Rating FormBaseline (12/21/2019)Post-treatment (1/27/2020)Apathy T-score:3347Disinhibition T-score:3543Executive Dysfunction T-score:3443FrSBe – SubscaleDescriptionApathy (A)Problems with initiation, psychomotor retardation, spontaneity, drive, persistence, loss of energy and interest, lack of concern about self-care and/or blunted affective expression.Disinhibition (D)Problems with inhibitory control such as impulsivity, hyperactivity, socially inappropriate behavior and poor conformity to social conventions.Executive Dysfunction (E)Problems with sustained attention, working memory, organization, planning, future orientation, sequencing, problem solving, insight, mental flexibility, self-monitoring of ongoing behavior and/or the ability to benefit from feedback or modify behavior following errors.FrSBe T-scoreInterpretationLess than 60Normal60-65Borderline impairmentMore than 65Clinically Significant Open table in a new tab
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