Self-organization Process Research Articles

The Origin of RNA and the Formose-Ribose-RNA Pathway.

Prebiotic pre-Darwinian reactions continued throughout biochemical or Darwinian evolution. Early chemical processes could have occurred on Earth between 4.5 and 3.6 billion years ago when cellular life was about to come into being. Pre-Darwinian evolution assumes the development of hereditary elements but does not regard them as self-organizing processes. The presence of biochemical self-organization after the pre-Darwinian evolution did not justify distinguishing between different types of evolution. From the many possible solutions, evolution selected from among those stable reactions that led to catalytic networks, and under gradually changing external conditions produced a reproducible, yet constantly evolving and adaptable, living system. Major abiotic factors included sunlight, precipitation, air, minerals, soil and the Earth's atmosphere, hydrosphere and lithosphere. Abiotic sources of chemicals contributed to the formation of prebiotic RNA, the development of genetic RNA, the RNA World and the initial life forms on Earth and the transition of genRNA to the DNA Empire, and eventually to the multitude of life forms today. The transition from the RNA World to the DNA Empire generated new processes such as oxygenic photosynthesis and the hierarchical arrangement of processes involved in the transfer of genetic information. The objective of this work is to unite earlier work dealing with the formose, the origin and synthesis of ribose and RNA reactions that were published as a series of independent reactions. These reactions are now regarded as the first metabolic pathway.

EL ESTUDIO COMO PRINCIPIO EDUCATIVO Y LA CUESTIÓN DE LA LECTURA EN LA PEDAGOGÍA DEL MOVIMIENTO

The aim of this paper is to present notes on study as an educational principle in the Pedagogy of Movement, the Landless Rural Workers Movement (MST), with emphasis on the topic of reading. This is a documental and bibliographic research, based mainly on texts by the MST and by authors dedicated to the themes at hand. Education occupies a strategic space in the process of self-organization of the Landless organization. The Movement presents study as one of its organizational and educational principles. Several MST documents mention or refer, directly or indirectly, to the question of reading, writing and/or arithmetic. Thus, the study, which includes the readings, is configured as a key element for the process of self-organization, (auto)education, self-support and democratic management in the various activities of the MST, in the political, cultural and, mainly, economic spheres, which is fundamental for the material and symbolic reproduction of this Movement.

The Self-Organization and Gelation Processes in a Cysteine–Silver Solution Containing Chitosan and an Electrolyte

The Self-Organization and Gelation Processes in a Cysteine–Silver Solution Containing Chitosan and an Electrolyte

Pattern transitions in diary data of MDD patients: a mixed-methods multiple case study of psychotherapy dynamics.

Mixed-methods approaches promise a deep understanding of psychotherapeutic processes. This study uses qualitative and quantitative data from daily diary entries and daily self-assessments during inpatient treatment. The aim of the study is to get an insight into the similarities and differences between both types of data and how they represent self-organized pattern transitions in psychotherapy. While a complete correlation of results is not expected, we anticipate observing amplifying and subsidiary patterns from both perspectives. Daily, five MDD patients wrote diaries and completed self-assessments using the Therapy Process Questionnaire, a questionnaire for monitoring the change dynamics of psychotherapy. The data were collected using the Synergetic Navigation System, an online tool for real-time monitoring. Diary entries of the patients described their experiences in everyday life. The qualitative text analysis was conducted using Mixed Grounded Theory, which provided categories representing the patients' ongoing experiences of transformation and stagnation. The time series data was analyzed using the dynamic complexity algorithm and the pattern transition detection algorithm. Results from qualitative and quantitative analyses were combined and compared. Following the process of data triangulation, the leading perspective came from the theory of self-organization. In addition to presenting the overall results for all five patients, we delve into two specific case examples in greater detail. Specific and highly diversified diary entries of 5 patients were classified into the categories of perceived pattern stability, noticing improvement, broadening the perspective, critical instability, and experiencing moments of Kairos. Patients reported problems not only related to their disorder (e.g., lack of energy and hopelessness) but also to phases and steps of change, which could be related to the theory of self-organization (e.g., problem attractors, critical fluctuations, pattern transitions, and Kairos). Qualitative and quantitative analysis provide important supplementary results without being redundant or identical. Data triangulation allows for a comprehensive and multi-perspective understanding of therapeutic change dynamics. The different topics expressed in the diary entries especially help to follow micro-psychological processes, which are far from being a simple reaction to interventions. The way patients experience themselves being in stability or instability and stagnation or transformation is surprisingly close to the general features of self-organizing processes in complex systems.

Percolation phase transition, self-organization processes and thermal conductivity in PbSe1-xTex semiconductor solid solutions at small Te concentration

ABSTRACT The isotherms of the lattice thermal conductivity λ L for the PbSe1-xTex semiconductor solid solutions (х = 0–0.045) were obtained in the temperature range T = (200–600) K. The λ L(x) dependences exhibit a general trend to a decrease in λ L with increasing x, but the peaks are observed near x = 0.007, 0.015 and 0.0025 indicating the presence of phase transformations. We associated the first peak with a percolation-type phase transition to the impurity continuum and estimated the critical index for λ L within the framework of dynamic scaling theory. The second and third peaks were attributed to the self-organization processes in the PbSe1-xTex after the percolation threshold reaching. The effective cross-sections σ s for phonon scattering by impurity (Te) atoms were determined experimentally and calculated theoretically using the Klemens theory. The data obtained are another confirmation of our assumption about the presence of such percolation-type phase transition in any solid solution.

Exploring the Synthesis of Self-Organization and Active Motion.

Proteins, genetic material, and membranes are fundamental to all known organisms, yet these components alone do not constitute life. Life emerges from the dynamic processes of self-organization, assembly, and active motion, suggesting the existence of similar artificial systems. Against this backdrop, our Perspective explores a variety of chemical phenomena illustrating how nonequilibrium self-organization and micromotors contribute to life-like behavior and functionalities. After explaining key terms, we discuss specific examples including enzymatic motion, diffusiophoretic and bubble-driven self-propulsion, pattern-forming reaction-diffusion systems, self-assembling inorganic aggregates, and hierarchically emergent phenomena. We also provide a roadmap for combining self-organization and active motion and discuss possible outcomes through biological analogs. We suggest that this research direction, deeply rooted in physical chemistry, offers opportunities for further development with broad impacts on related sciences and technologies.

Complexity, Coordination Dynamics and the Urban Landscape

Similar to living complex systems, cities are composed of a huge number of interacting parts, each with its specific properties, rhythm, etc., that, by means of self-organization, give rise to a functioning complex system. A major challenge is thus to follow the self-organized adaptation process by which the huge number of diverse parts coordinate their action and behavior into a coherent whole. Coordination dynamics, the science of coordination, elaborates on this issue, showing how patterns of coordination form, adapt, persist and change in living things. Recent studies on cities and complexity exposed that human agents differ from other living things in that they adapt not only through behavior but also through the construction of artifacts, thus giving rise to hybrid complex systems (HCSs) and to cities as such. This entails a new challenge regarding the various aspects and roles of artifacts in coordination dynamics. This study introduces the notions of hybrid complex systems and coordination dynamics and then focuses on one aspect that concerns coordination in cities: the ways the artificial urban landscape participates in coordinating the dynamics between the human urban agents.

Aggregation of human osteoblasts unlocks self-reliant differentiation and constitutes a microenvironment for 3D-co-cultivation with other bone marrow cells

Skeletal bone function relies on both cells and cellular niches, which, when combined, provide guiding cues for the control of differentiation and remodeling processes. Here, we propose an in vitro 3D model based on human fetal osteoblasts, which eases the study of osteocyte commitment in vitro and thus provides a means to examine the influences of biomaterials, substances or cells on the regulation of these processes. Aggregates were formed from human fetal osteoblasts (hFOB1.19) and cultivated under proliferative, adipo- and osteoinductive conditions. When cultivated under osteoinductive conditions, the vitality of the aggregates was compromised, the expression levels of the mineralization-related gene DMP1 and the amount of calcification and matrix deposition were lower, and the growth of the spheroids stalled. However, within spheres under growth conditions without specific supplements, self-organization processes occur, which promote extracellular calcium deposition, and osteocyte-like cells develop. Long-term cultivated hFOB aggregates were free of necrotic areas. Moreover, hFOB aggregates cultivated under standard proliferative conditions supported the co-cultivation of human monocytes, microvascular endothelial cells and stromal cells. Overall, the model presented here comprises a self-organizing and easily accessible 3D osteoblast model for studying bone marrow formation and in vitro remodeling and thus provides a means to test druggable molecular pathways with the potential to promote life-long bone formation and remodeling.

Optimal input reverberation and homeostatic self-organization toward the edge of synchronization.

Transient or partial synchronization can be used to do computations, although a fully synchronized network is sometimes related to the onset of epileptic seizures. Here, we propose a homeostatic mechanism that is capable of maintaining a neuronal network at the edge of a synchronization transition, thereby avoiding the harmful consequences of a fully synchronized network. We model neurons by maps since they are dynamically richer than integrate-and-fire models and more computationally efficient than conductance-based approaches. We first describe the synchronization phase transition of a dense network of neurons with different tonic spiking frequencies coupled by gap junctions. We show that at the transition critical point, inputs optimally reverberate through the network activity through transient synchronization. Then, we introduce a local homeostatic dynamic in the synaptic coupling and show that it produces a robust self-organization toward the edge of this phase transition. We discuss the potential biological consequences of this self-organization process, such as its relation to the Brain Criticality hypothesis, its input processing capacity, and how its malfunction could lead to pathological synchronization and the onset of seizure-like activity.

Anti-Biofilm and Anti-Quorum-Sensing Activity of Inula Extracts: A Strategy for Modulating Chromobacterium violaceum Virulence Factors.

The formation of microbial biofilm is a self-organizing process among bacterial cells, regulated by quorum-sensing (QS) mechanisms, contributing to development of infections. These processes, either separately or in combination, significantly contribute to bacterial resistance to antibiotics and disinfectants. A novel approach to addressing the challenge of treating infections due to antibacterial resistance involves the use of plant metabolites. In recent years, there has been increasing recognition of different phytochemicals as potential modulators. In our study, we evaluated the synergistic effect of chloroform and methanol extracts from Inula species against key virulence factors, including biofilm formation, violacein production, and swarming motility. Each of the 11 examined plant extracts demonstrated the ability to reduce biofilms and pigment synthesis in C. violaceum. Two of the extracts from I. britannica exhibited significant anti-biofilm and anti-quorum-sensing effects with over 80% inhibition. Their inhibitory effect on violacein synthesis indicates their potential as anti-QS agents, likely attributed to their high concentration of terpenoids (triterpenoids, sesquiterpene lactones, and diterpenoids). Scanning electron microscopy revealed a notable reduction in biofilm biomass, along with changes in biofilm architecture and cell morphology. Additionally, fluorescence microscopy revealed the presence of metabolically inactive cells, indicating the potent activity of the extracts during treatment. These new findings underscore the effectiveness of the plant extracts from the genus Inula as potential anti-virulent agents against C. violaceum. They also propose a promising strategy for preventing or treating its biofilm formation.

Classicism in the Saratov region

Saratov’s classicism is the first stage of its capital construction. It plays a major role in the formation of the architectural environment of the historical center. Classicism also influences the formation of the central part of the city. The article considers the processes of organization and self-organization of buildings in Saratov during the period of Classicism.Purpose: Identification of classicism buildings in Saratov.Methodology/approach: The main levels of scientific knowledge are accepted: a theoretical method involving the study of documents describing the architecture of classicism, a practical method to determine the elements of the environment, their harmony, and the systems analysis of these documents.Research findings: Regional properties of Saratov are studied for the period of classicism.Value: A study of harmony in the architectural environment of the historical center Saratov.

Reintroducing Time, Money and Constraints: Viability to Bridge the Economic and Monetary Theories

Why use a viabilistic approach to model economy? Because it is urgent to re-assess the modeling of the business cycle that integrates dynamic money creation and that has at its core the notion of constraints. The purpose of this paper is thus to propose an evolutionary economic model using a mathematical framework derived from set-valued analysis, differential inclusions and viability theory. As this approach is dynamical, the model will not use two concepts on which neo-classical economics are built i.e., (1) the existence of static repeated equilibria, (2) the optimization by an economic agent of a utility function. Furthermore, we will not use any self-organization process or “invisible hand”, as in our viabilist framework the economic viability will be maintained by explicit choices of the economic agents and of the lender of last resort over the budgetary and monetary rules to apply. Indeed, even simple constraints on the second-derivative of the means of payments already induce four-phased business cycles. Coupling these constraints over the creation of means of payment with economic evolutions of prices and commodities through a budgetary constraint allows for a single formalism, tackling jointly the question of the viability of economic and monetary evolutions.

Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure.

Thermodynamic consequences of a three-hour long anoxia were investigated on the isolated mammalian rat myocardium. The anoxic heart operated in a far-from-equilibrium manner as attested by the non-linearity between the thermodynamic force and the thermodynamic flow. When subjected to slight fluctuations due to anoxia, the open far-from-equilibrium cardiac system presented a thermodynamic bifurcation at ~ 60 minutes of anoxia. The bifurcation was characterized by a sudden change of direction in the bifurcation diagram of a one-dimensional nonlinear differential equation with one parameter and occurred at a non-hyperbolic fixed point at which moment the heart lost its thermodynamic stability. The parameter of the differential equation was the single force of the myosin molecular motor. These results helped to reflect a self-organized process and the occurrence of a dissipative structure. This offers valuable insights into our understanding of myocardial protection and could be of considerable interest, especially for heart transplants where the recipient must benefit from the donor's heart in the shortest possible time.

Dissipative Structures and Self-Organization Process in an Abstract Model of Neural Network

This preliminary study shows an abstract model of the learning process; it will be identified as creating a dissipative structure and forming a self-organization process.The dissipative structure will provoke a correlation within the whole system using the associated symmetry-breaking process.

Surface relief structures for light coupling at air/liquid interface

Relief patterns were photoinduced on the surface of a thin film floating on water. The structures have a length of several millimeters with a width of 33 μm. Both the intensity and the polarization of the irradiated light change the characteristics of the generated patterns. The light induced structuration is the result of simultaneously a reversible material transport originated by photoisomerization of azobenzene units and a process of self-organization of the molecules. The structures were used as waveguide or grating to couple light at the air/liquid interface on a short or long distance. The fabrication of waveguides can be extended to any liquid substrates.

Event-Management in Socio-Cultural Space: Analysis of the Life-Cycle Stages Conceptions According to the Modern Conditions

Relevance. Modern management practice increasingly considerate behavioral aspects, including features of decision-making, influence of impressions. This gives special significance to those areas allowing to combine both components. So then special events are gaining interest. The purpose is to identify the appropriate approach to life cycle of the technological process in event-management development. Objectives: systematize and comparatively analyze existing concepts, identify key factors influencing the feasibility of these, formulate a concept that makes it possible to increase the effectiveness of events in terms of providing targeted impact. Methodology includes comparative and system analysis. Synthesis makes it possible to single out optimal for modern conditions approach. Results. Systematizes and analyzes the existing approaches to determining the stages of the life cycle in event-management. The author classifies the existing concepts into short-term and long-term ones, differing in the composition of the management system and the features of its relations. Formulates two approaches to indicate event management system actors. Based on the importance of informative and social factors, the specifics of event management correlation with social factors during the life circle unvailes. Conclusions. Many of existing approaches overlook the influence of self-organizational processes in the controlled subsystem (visitors) on the final impact. The author proposes an integrative life cycle model with factors previously ignored: the influence of reference groups (including online communities), event representation in digital environment.

An Ecosystem Approach to Balanced Territorial Development

Relevance. The problems of sustainable development of rural areas are extremely relevant nowadays, especially in the context of deepening localization and the increasing role of territorial and natural resources. research objective. The purpose of the article is to develop theoretical and methodological aspects of sustainable development of territories, encompassing rural areas with small urban settlements, based on the ecosystem approach to form a unified multi-level strategy for the development thereof. Method and data. The paper substantiates an application of the ecosystem approach to the development of rural areas in increasing the efficiency of rural businesses, budgetary spending through prioritization of state support recipients, stimulating sustainable development of enterprises and the industry, and increasing the consistency of regional economic policy. The conceptual foundations of this approach are presented, and an algorithm to select participants in a rural ecosystem is proposed. results. The proposed approach allows operationalizing self-organization processes in an ecosystem, ensuring a balance of interaction processes of its participants. The research results have contributed to solving the problem of territorial socio-economic ecosystem formation by proposing an algorithm to select target indicators for achieving sustainable development goals, taking into account the specifics and development trends of territories. Conclusions. The conclusions arising from the conducted research provide scientists, government bodies with the necessary information for a better understanding of practical mechanisms to provide balanced territorial development, ensure the move from fragmentary unsystematic measures of state support to effective differentiated and targeted regional policy of rural areas.

Survivalist Organizing in Urban Poverty Contexts

Institutional scholarship on organizing in poverty contexts has focused on the constraining nature of extant institutions and the need for external actors to make transformative change interventions to alleviate poverty. Comparatively little attention has been paid to the potentially enabling nature of extant institutions in poverty contexts. We argue that more empirical work is needed to deepen our understanding of self-organizing processes that actors embedded in such contexts generate in their own efforts to survive. Drawing on the social worlds approach to institutional analysis, we shed light on how actors self-organize to produce enduring organizational arrangements to safeguard themselves against adverse poverty outcomes. Employing data from fieldwork and interviews collected in the urban neighborhood of Dagoretti Corner in Nairobi, Kenya, we examine the colocation of 105 largely identical auto repair businesses in close spatial proximity. We find that actors leverage an indigenous institution—the societal ethos of Harambee—to enable a process we identify as “survivalist organizing.” Based on our research, we argue that survivalist organizing incorporates four interlocking survival mechanisms: cultivating interbusiness solidarity, maintaining precarious interbusiness relationships, redistributing resources to prevent business deaths, and generating collective philanthropy to avoid personal destitution. We develop a new research agenda on the institutional study of self-organizing in poverty contexts focused on strengthening rather than supplanting urbanized indigenous institutions that catalyze collective self-organizing. Funding: This work was supported by the China National Science Foundation [Grants 72091310 and 72091315].

Advances in 3D Culture Models to Study Exosomes in Triple-Negative Breast Cancer.

Breast cancer, a leading cause of cancer-related deaths globally, exhibits distinct subtypes with varying pathological, genetic, and clinical characteristics. Despite advancements in breast cancer treatments, its histological and molecular heterogeneity pose a significant clinical challenge. Triple-negative breast cancer (TNBC), a highly aggressive subtype lacking targeted therapeutics, adds to the complexity of breast cancer treatment. Recent years have witnessed the development of advanced 3D culture technologies, such as organoids and spheroids, providing more representative models of healthy human tissue and various malignancies. These structures, resembling organs in structure and function, are generated from stem cells or organ-specific progenitor cells via self-organizing processes. Notably, 3D culture systems bridge the gap between 2D cultures and in vivo studies, offering a more accurate representation of in vivo tumors' characteristics. Exosomes, small nano-sized molecules secreted by breast cancer and stromal/cancer-associated fibroblast cells, have garnered significant attention. They play a crucial role in cell-to-cell communication, influencing tumor progression, invasion, and metastasis. The 3D culture environment enhances exosome efficiency compared to traditional 2D cultures, impacting the transfer of specific cargoes and therapeutic effects. Furthermore, 3D exosomes have shown promise in improving therapeutic outcomes, acting as potential vehicles for cancer treatment administration. Studies have demonstrated their role in pro-angiogenesis and their innate therapeutic potential in mimicking cellular therapies without side effects. The 3D exosome model holds potential for addressing challenges associated with drug resistance, offering insights into the mechanisms underlying multidrug resistance and serving as a platform for drug screening. This review seeks to emphasize the crucial role of 3D culture systems in studying breast cancer, especially in understanding the involvement of exosomes in cancer pathology.

Collective dynamics of swarmalators with higher-order interactions

AbstractHigher-order interactions shape collective dynamics, but how they affect transitions between different states in swarmalator systems is yet to be determined. To that effect, we here study an analytically tractable swarmalator model that incorporates both pairwise and higher-order interactions, resulting in four distinct collective states: async, phase wave, mixed, and sync states. We show that even a minute fraction of higher-order interactions induces abrupt transitions from the async state to the phase wave and the sync state. We also show that higher-order interactions facilitate an abrupt transition from the phase wave to the sync state bypassing the intermediate mixed state. Moreover, elevated levels of higher-order interactions can sustain the presence of phase wave and sync state, even when pairwise interactions lean towards repulsion. The insights gained from these findings unveil self-organizing processes that hold the potential to explain sudden transitions between various collective states in numerous real-world systems.