Self-generated Signal Research Articles

A PCA Based Artifact Removal Algorithm for Neural Signal Acquisition with kS/s Sampling Rate.

The contamination of stimulus artifacts during Deep Brain Stimulation (DBS) brings challenges to the signal processing, especially when the ratio of the kS/s sampling rate to the stimulation frequency is not an integer. In this work we study to deal with this problem. A transfer function is built to describe the relationship between the stimulation signal and the artifact at the acquisition site. A principal component analysis (PCA) based linear regression algorithm for eliminating the artifact is proposed. The algorithm can be used for the artifact removal with low sampling rate of the neural signal. Higher than 60% correlation coefficient of the artifact-free signal and the predetermined self-generated signal is achieved when the artifact is 60dB larger than the predetermined signal. The numerical recipe for the critical algorithm is also proposed, lowering the complexity from cubic degree to square degree.

Artificial Intelligence-Assisted Throat Sensor Using Ionic Polymer–Metal Composite (IPMC) Material

Throat sensing has received increasing demands in recent years, especially for oropharyngeal treatment applications. The conventional videofluoroscopy (VFS) approach is limited by either exposing the patient to radiation or incurring expensive costs on sophisticated equipment as well as well-trained speech-language pathologists. Here, we propose a smart and non-invasive throat sensor that can be fabricated using an ionic polymer–metal composite (IPMC) material. Through the cation’s movement inside the IPMC material, the sensor can detect muscle movement at the throat using a self-generated signal. We have further improved the output responses of the sensor by coating it with a corrosive-resistant gold material. A support vector machine algorithm is used to train the sensor in recognizing the pattern of the throat movements, with a high accuracy of 95%. Our proposed throat sensor has revealed its potential to be used as a promising solution for smart healthcare devices, which can benefit many practical applications such as human–machine interactions, sports training, and rehabilitation.

The captivating effect of electric organ discharges: species, sex and orientation are embedded in every single received image.

Some fish communicate using pulsatile, stereotyped electric organ discharges (EODs) that exhibit species- and sex-specific time courses. To ensure reproductive success, they must be able to discriminate conspecifics from sympatric species in the muddy waters they inhabit. We have previously shown that fish in both Gymnotus and Brachyhypopomus genera use the electric field lines as a tracking guide to approach conspecifics (electrotaxis). Here, we show that the social species Brachyhypopomus gauderio uses electrotaxis to arrive abreast a conspecific, coming from behind. Stimulus image analysis shows that, even in a uniform field, every single EOD causes an image in which the gradient and the local field time courses contain enough information to allow the fish to evaluate the conspecific sex, and to find the path to reach it. Using a forced-choice test, we show that sexually mature individuals orient themselves along a uniform field in the direction encoded by the time course characteristic of the opposite sex. This indicates that these fish use the stimulus image profile as a spatial guidance clue to find a mate. Embedding species, sex and orientation cues is a particular example of how species can encode multiple messages in the same self-generated communication signal carrier, allowing for other signal parameters (e.g. EOD timing) to carry additional, often circumstantial, messages. This 'multiple messages' EOD embedding approach expressed in this species is likely to be a common and successful strategy that is widespread across evolutionary lineages and among varied signaling modalities.

Piecewise Quadratic Slope Compensation Technique for DC-DC Switching Converters

In this paper, a piecewise quadratic slope compensation technique for eliminating subharmonic oscillations in dc-dc switching converters is studied. With this technique, a self-generated signal is used in the compensation scheme resulting in a naturally full duty cycle stability domain. The expression of the piecewise quadratic compensating signal within a switching cycle is derived. It is obtained that the steady-state value of the amplitude of this signal is the same as in the conventional linear slope compensation scheme that guarantees stability for all values of the duty cycle. However, in the piecewise quadratic scheme this is achieved without exact knowledge of the inductance value nor sensing the input and the output voltages. The stability of the converter under the considered compensation scheme is also guaranteed for all values of the duty cycle with voltage loop open. A boost converter under peak current mode control is used to validate the theoretical results both by numerical simulations and by experiments. Simulation results are analyzed and compared to the performances of the state-of-art techniques with voltage loop closed.

Cell-Cell Communication (Quroum Sensing) in Gram-Negative and Gram-Positive Bacteria: A Review

Quorum sensing indicates to the capability of a bacterium to sense information from other members in the population when they compass a critical concentration and connect with them. The mode used for this intercellular connection is depend on small, self-generated signal molecules called as autoinducers. Quorum sensing is refection to endure pathogenic bacteria mechanism to reduce host immune responses by retardant the forming of tissue-destroying virulence factors until adequate bacteria have accumulated and are destined to crush host defense mechanisms and set infection. Among these pathogenic bacteria, Gram negative bacteria such as Pseudomonas aeruginosa, Vibrio spp., and Escherichia coli as well as Gram positive bacteria; S. aureus and Clostridium perfringens are probably the best understood in terms of the virulence factors regulated by the Quorum sensing that plays a role in the pathogenicity. In conclusion bacteria do not live separated, but rather they communicate using varied chemical languages.

Research on Self-Generated Voltage of Friction Pair in Dry Wear Process

When friction pair contact with each other, self-generated voltage is a macroscopic potential difference manifested in the face of friction pair as a result of the interaction of diversified factor. It is consisted of contact potential between two different materials, thermal electromotive force in the friction process between two different materials, potential difference created by charge change in the contact and abruption process of friction pair and potential difference created by material transfer in the friction process. Self-generated voltage is measured in the paper through measuring system, and then the relation between self-generated voltage and frictional characteristic is analyzed. It is concluded useful to study observation and diagnosis of equipment friction with self-generated voltage signal of metal friction pair.

Quorum sensing and Bacterial Pathogenicity: From Molecules to Disease

Quorum sensing in prokaryotic biology refers to the ability of a bacterium to sense information from other cells in the population when they reach a critical concentration (i.e. a Quorum) and communicate with them. The “language” used for this intercellular communication is based on small, self-generated signal molecules called as autoinducers. Quorum sensing is thought to afford pathogenic bacteriaa mechanism to minimize host immune responses by delaying theproduction of tissue-damaging virulence factors until sufficientbacteria have amassed and are prepared to overwhelm host defensemechanisms and establish infection. Quorum sensing systems are studied in a large number of gram-negative bacterial species belonging to α, β, and γ subclasses of proteobacteria. Among the pathogenic bacteria, Pseudomonas aeruginosa is perhaps the best understood in terms of the virulence factors regulated and the role the Quorum sensing plays in pathogenicity. Presently, Quorum sensing is considered as a potential novel target for antimicrobial therapy to control multi/all drug-resistant infections. This paper reviews Quorum sensing in gram positive and gram negative bacteria and its role in biofilm formation.

Occurrence of N-acyl- l-homoserine lactones in extracts of some Gram-negative bacteria evaluated by gas chromatography–mass spectrometry

Acylated homoserine lactones (AHLs) are self-generated signal molecules that mediate population density-dependent gene expression (quorum sensing) in a variety of Gram-negative bacteria. These signal molecules diffuse from bacterial cells and accumulate in the medium as a function of cell growth. In selected foods AHLs contribute to product spoilage. As different bacterial species produce AHL analogs that differ in length of the N-acyl chain, ranging from 4 to 14 carbons and in the substitution at the C-3 position of the side chain (i.e., oxo or hydroxyl group), the suitability and applicability of a gas chromatography–mass spectrometry direct method for characterizing trace amounts of AHLs was evaluated using N-heptanoyl-homoserine lactone as internal standard. Crude cell-free supernatants of bacterial cultures of Aeromonas hydrophila, Aeromonas salmonicida, Pseudomonas aeruginosa, Pseudomonas fluorescens, Yersinia enterocolitica, and Serratia liquefaciens were screened for AHL production in selected ion monitoring mode, using the prominent fragment at m/ z 143. The observed profiles of distinguishable N-acyl-homoserine lactones occurring in bacterial extracts were compared and discussed. The presence of a labile 3-oxo-hexanoylhomoserine lactone was evidenced but serious difficulties arose in estimating its concentration as thermal degradation occurs during the gas chromatographic separation. Its electron impact mass spectra was, however, given and interpreted.

90% pump depletion and good beam quality in a pulse-injection-seeded nanosecond optical parametric oscillator

We measured 90% pump depletion in a singly resonant image-rotating nanosecond optical parametric oscillator that was pulse-injection seeded by a self-generated signal pulse. The oscillator was pumped by an 8 ns duration single-frequency 532 nm pulse from an injection-seeded Q-switched Nd:YAG laser and resonated an 803 nm signal. The pump and pulsed-seed beams had flat-topped spatial fluence profiles with diameters of approximately 6 mm, giving a cavity Fresnel number at 803 nm approaching 400. The beam cleanup effects of the image-rotating cavity produce a far-field signal spatial fluence profile with approximately 60% of its energy falling within the diffraction-limited spot size.

Bacterial quorum sensing in pathogenic relationships.

Bacteria were for a long time believed to exist as individual cells that sought primarily to find nutrients and multiply. The discovery of intercellular communication among bacteria has led to the realization that bacteria are capable of coordinated activity that was once believed to be restricted to multicellular organisms. The capacity to behave collectively as a group has obvious advantages, for example, the ability to migrate to a more suitable environment/better nutrient supply and to adopt new modes of growth, such as sporulation or biofilm formation, which may afford protection from deleterious environments. The “language” used for this intercellular communication is based on small, self-generated signal molecules called autoinducers. Through the use of autoinducers, bacteria can regulate their behavior according to population density. The phenomenon of quorum sensing, or cell-to-cell communication, relies on the principle that when a single bacterium releases autoinducers (AIs) into the environment, their concentration is too low to be detected. However, when sufficient bacteria are present, autoinducer concentrations reach a threshold level that allows the bacteria to sense a critical cell mass and, in response, to activate or repress target genes. Most of the bacteria thus far identified that utilize quorum-sensing systems are associated in some way with plants or animals. The nature of these relationships can be either amicable, as characterized by symbiotic bacteria, or adversarial, as seen with pathogenic bacteria. There are numerous bacteria that have components of a quorum-sensing system for which the phenotype regulated remains an enigma. Similarly, there are bacteria known to regulate a specific phenotype via quorum sensing for which one or more of the regulatory components have thus far eluded identification. In this review we give examples of pathogenic relationships, focusing on organisms for which many of the facets of their quorum-sensing systems have been elucidated.

An Adaptive Interference Canceling Array Utilizing Hybrid Techniques

The steady state properties of an adaptive array utilizing prior knowledge of both approximate signal arrival direction and signal characteristics are presented. The method combines the features of a directionally constrained array and an array with a self-generated reference signal. Explicit results are obtained for output signal, interference, and noise powers assuming a single interferer is present. The inclusion of a self-generated reference circuit is shown to reduce the sensitivity to pointing error typical of arrays utilizing a zero order directional constraint, the improvement being a consequence of the reduction of the desired signal component fed back to the sidelobe canceling circuit. A relationship between the degree of sensitivity reduction and the quality of the reference signal is developed. Results of computations of signal to interference plus noise ratios for a 7-element 10-wavelength nonuniformly spaced array as a function of pointing error are presented. These results show the behavior with one interferer inside and outside the beamwidth of the quiescent array and with multiple interferers for various degrees of perfection of the reference generating circuit. In all cases the computations confirm that the otherwise severe effects of small pointing errors are substantially reduced.