The aim of this study is to identify how professionalism and systems thinking contribute to patient safety competency among Iranian nurses. Professionalism, systems thinking and patient safety competency play important roles in the quality of care. Strategies to enhance the patient safety competency of nurses must be devised by identifying the relationships between these variables. A cross-sectional, descriptive survey study was conducted in 10 teaching hospitals in Tabriz, Iran. A total of 358 nursing staff with at least 12 months of experience in nursing were enrolled. Data were collected using the Professionalism scale, Systems Thinking Scale and Patient Safety Competency Self-Evaluation tool. Structural equation modelling analysis was performed to test the relationship between variables. The final model illustrated a good fit (χ2 /df =2.329, goodness-of-fit index =0.990, Tucker-Lewis index =0.906 and root mean square error of approximation =0.068). Professionalism directly influenced patient safety competency (β =0.59, p<0.001) and indirectly influenced systems thinking (β =0.29, p<0.001). Systems thinking directly influenced patient safety competency (β =0.46, p<0.001). Results indicated that 91% of the variance in patient safety competency was explained by professionalism while 40.1% of the variance in the systems thinking was explained by professionalism. The professionalism and systems thinking of hospital nurses play a pivotal role as predictors in patient safety competency. Training opportunities, mentorship and nursing managers' leadership are needed to assist hospital nurses in their perceptions of professionalism and systems thinking. Nursing educators and managers should implement patient safety training strategies and improve the professionalism and systems thinking of hospital nurses to promote patient safety and quality care.
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