Self-directed Violence Research Articles

Youth Suicide Attempt Nomenclature Used in Two Central Texas Hospitals.

Surveillance systems capturing instances of self-directed violence (SDV) continue to lack uniform nomenclature and classification methodology. To apply and compare two retrospective surveillance approaches to youth experiencing SDV presenting to two urban hospitals with Level I Trauma Centers. Two suicide attempt surveillance methods where retrospectively applied to our SDV cohort: (a) a rigorous method facilitated by medical record review and application of standardized classification; and (b) a common surveillance method conducted by systematic queries of suicide attempt key terms and diagnosis codes among hospital databases. Rigorous surveillance identified 249 patients attempting suicide. The common method's querying suicide attempt in the chief complaint field had a high positive predictive value and specificity; however, sensitivity was low. Authors were unable to determine whether all SDV encounters during the study timeframe were identified for initial screening owing to the hospital's lack of a uniform nomenclature or classification system. Results showed underreporting of suicide attempt cases, inadequate sensitivity and specificity in common surveillance methods, and skewed demographic representation compared with the rigorous surveillance method. This study elucidates the negative impact of inconsistent SDV nomenclature including impeding effective patient identification, treatment, surveillance, and generalizable research.

Predictors of Unbearability, Unlovability, and Unsolvability in Veterans With Military-Sexual-Trauma-Related Posttraumatic Stress Disorder.

Military sexual trauma (MST) and posttraumatic stress disorder (PTSD) both increase risk for suicidal self-directed violence (SDV). Suicide cognitions (i.e., unbearability, unlovability, and unsolvability) are strong predictors of future suicidal SDV. The present study investigated potential predictors of unbearability, unlovability, and unsolvability in veterans with MST-related PTSD. Suicide cognitions, depression, PTSD, quality of life, trauma-related negative cognitions, physical health functioning, mental health functioning, and childhood sexual assault were assessed in 12 male and 103 female veterans with MST-related PTSD. Higher depression scores, greater trauma-related negative cognitions about self, and poorer physical health functioning predicted increased unbearability scores. Greater trauma-related negative cognitions about self and self-blame, higher level of education, and higher depression scores predicted increased unlovability scores. Higher depression scores and greater trauma-related negative cognitions about self predicted increased unsolvability scores. In veterans with MST-related PTSD who express unbearability, unlovability, and unsolvability, assessing and addressing depression, trauma-related negative cognitions about self and self-blame, and physical health functioning may be an important step in reducing SDV.

Physical and Psychological Violence against Married Men in District Dir (Lower), Khyber Pukhtoonkhwa, Pakistan

The World Health Organization [1] has defined violence as “the intentional use of physical force, threatened or actual, against oneself, another person, or against a group or community, that either results in, or has a high likelihood of resulting in injury, death, psychological harm, mal-development or deprivation’’ [1]. According to the WHO [1] typology of violence, there are mainly three types, such as, self-directed, interpersonal, and collective violence; these types are further divided into subtypes [1]. The current study focused on interpersonal (intimate partner or domestic) violence against married men. The Intimate Partner Violence (IPV) can be defined as the physical, psychological, or sexual harm by current/previous partner or spouse; domestic violence is used interchangeably with IPVs [2]. Violence against women is extensively studied in different parts of the western world and Asian countries; however, very few of the researchers have paid attention towards violence against men [3,4]; Hines et al. [5] it is commonly claimed that men are traditionally viewed as being physically stronger than women, therefore, they under-report their victimization due to barriers like embarrassment and masculine ego [6]. The fact that men are victims of IPV, from their female partners, has been identified for the last thirty years [5]; these victims often face the humiliation of being laughed at, accused, belittled, or ridiculed, due to which they do not report their victimization [6]. Studies have identified equal levels of exposure to intimate partner violence among men and women [7]; the rates and frequencies of violence enacted by women are often similar to that of their men partners [8]. Such symmetry signifies a weak association of gender with perpetration of IPV. However, men’s ego has been developed by the society in such a way that their reporting of violence is generally considered a social stigma. When men attempt to report DV against them, most of the times they are not trusted; instead, they are laughed at and ridiculed for the notion that they are beaten by their wives

Dialectical Behavior Therapy Is Effective for the Treatment of Suicidal Behavior: A Meta-Analysis

Dialectical Behavior Therapy (DBT) prioritizes suicidal behavior and other self-directed violence as the primary treatment targets, and has been demonstrated to reduce self-directed violence in clinical trials. This paper synthesizes findings from controlled trials that assessed self-directed violence and suicidality, including suicide attempts, non-suicidal self-injury (NSSI), suicidal ideation, and accessing psychiatric crisis services. Eighteen controlled trials of DBT were identified. Random effects meta-analyses demonstrated that DBT reduced self-directed violence (d = -.324, 95% CI = -.471 to -.176), and reduced frequency of psychiatric crisis services (d = -.379, 95% CI = -.581 to -.176). There was not a significant pooled effect of DBT with regard to suicidal ideation (d = -.229, 95% CI = -.473 to .016). Our findings may reflect the prioritization of behavior over thoughts within DBT, and offer implications for clinical practice and future research concerning the implementation of DBT for acute suicidality.

Association of Religiosity With Sexual Minority Suicide Ideation and Attempt

The purpose of this study is to explore how the associations between importance of religion and recent suicide ideation, recent suicide attempt, and lifetime suicide attempt vary by sexual orientation. Survey data were collected from the 2011 University of Texas at Austin's Research Consortium data from 21,247 college-enrolled young adults aged 18-30 years. Respondents reported sexual identity as heterosexual, gay/lesbian, bisexual, or questioning. Two sets of multivariable models were conducted to explore the relations of religious importance and sexual orientation with the prevalence of suicidal behavior. The first model was stratified by sexual orientation and the second model was stratified by importance of religion. To explore potential gender differences in self-directed violence, the models were also stratified by gender identity. The main outcome measures were recent suicidal ideation, recent suicide attempt, and lifetime suicide attempt. Overall, increased importance of religion was associated with higher odds of recent suicide ideation for both gay/lesbian and questioning students. The association between sexual orientation and self-directed violence were mixed and varied by strata. Lesbian/gay students who viewed religion as very important had greater odds for recent suicidal ideation and lifetime suicide attempt compared with heterosexual individuals. Bisexual and questioning sexual orientations were significantly associated with recent suicide ideation, recent attempt, and lifetime attempt across all strata of religious importance, but the strongest effects were among those who reported that religion was very important. Religion-based services for mental health and suicide prevention may not benefit gay/lesbian, bisexual, or questioning individuals. Religion-based service providers should actively assure their services are open and supportive of gay/lesbian, bisexual, or questioning individuals.

Nursing diagnoses related to psychiatric adult inpatient care.

To detect the prevalence of NANDA-I diagnoses and possible relationships between those and patient characteristics such as gender, age, medical diagnoses and psychiatric specialty/setting. There is a lack on studies about psychiatric inpatient characteristics and possible relationships among these characteristics with nursing diagnoses. A quantitative-descriptive, cross-sectional, completed data sampling study was performed. The data were collected from the electronic patient record system. Frequencies for the social-demographic data, the prevalence of the NANDA-I diagnoses and the explanatory variables were calculated. In total, 410 nursing phenomena were found representing 85 different NANDA-I diagnoses in 312 patients. The NANDA-I diagnosis "Ineffective Coping" was the most frequently stated diagnosis followed by "Ineffective Health Maintenance," "Hopelessness" and "Risk for Other-Directed Violence". Men were more frequently affected by the diagnoses "Ineffective Coping," "Hopelessness," "Risk for Self-Directed Violence," "Defensive Coping" and "Risk for Suicide," whereas the diagnoses "Insomnia," "Chronic Confusion," "Chronic Low Self-Esteem" and "Anxiety" were more common in women. Patients under the age of 45years were more frequently affected by "Chronic Low Self-Esteem" and "Anxiety" than older patients. "Ineffective Coping" was the most prevalent diagnosis by patients with mental disorders due to psychoactive substance use. Patients with schizophrenia were primarily affected by the diagnoses "Ineffective Coping," "Impaired Social Interaction" and "Chronic Low Self-Esteem." This study demonstrates the complexity and diversity of nursing care in inpatient psychiatric settings. Patients' gender, age and psychiatric diagnoses and settings are a key factor for specific nursing diagnosis. There are tendencies for relationships between certain nursing diagnosis and patient characteristics in psychiatric adult inpatients. This enhances the specific, extended knowledge for nursing care and its demands in this setting and therefore supports the daily nursing psychiatric care and its needs.

The Association Between Sickle Cell Trait in U.S. Service Members with Deployment, Length of Service, and Mortality, 1992-2012.

Sickle cell trait (SCT) affects an estimated 5.02% of non-Hispanic blacks, 1.08% of Hispanics, and 0.1% of Whites in the U.S. military. Policies for SCT screening and occupational restrictions vary by service. Population-based studies of SCT with quantification of military-relevant outcomes are lacking. The study design was a retrospective cohort of 15,081 SCT-positive versus 60,320 SCT-negative U.S. active duty personnel enlisted from 1992 to 2012 and followed through 2013. Military-relevant outcome included number and days of deployment, length of service, and cause of death. SCT-positive versus SCT-negative service members experienced more deployments (p < 0.01) and longer number of days deployed for all services, especially the Army (p < 0.001). The median length of service was longer for SCT-positive service members stratified by service and by gender (p < 0.05). The adjusted risk of length of service greater than 5 yr by SCT status was 1.37 (95% confidence interval 1.31-1.43) with greater than a three-fold higher risk in the Navy and Air Force compared with the Army. Crude mortality rate was not significantly different by SCT status, although deaths due to suicide, self-directed violence, and other non-specific causes were more common in SCT-positive service members. We found that SCT-positive service members deployed more frequently, for greater lengths of time, and remained in service longer. No significant difference in crude mortality ratio was discovered. Additional research on military-relevant outcomes and a cost-effectiveness analysis of SCT screening practices are needed to inform evidence-based SCT enlistment policies.

Initial validation of the Self-Directed Violence Picture System (SDVPS).

A better understanding of factors that differentiate those who only experience suicidal ideation from those who engage in self-directed violence (SDV) is critical for suicide prevention efforts (Klonsky & May, 2014; May & Klonsky, 2016). To identify who is at greatest risk for death by suicide, it is imperative that new innovative assessment tools be created to facilitate behavioral measurement of key constructs associated with increased risk for SDV. The aim of the current study was to develop and validate a set of suicide-specific images, called the Self-Directed Violence Picture System (SDVPS), to help meet this need. A sample of 119 U.S. military veterans provided valence, arousal, and dominance ratings on the SDVPS. These ratings were compared to International Affective Picture System (IAPS) negative, neutral, and positive images. SDVPS images were rated with significantly greater negative valence and elicited decreased feelings of being in control than did IAPS positive (p < .001, p < .001), IAPS negative (p = .03, p = .001), and IAPS neutral (p < .001, p < .001) images. SDVPS images were also rated with significantly greater arousal than were IAPS neutral images (p < .001). Initial validation data support that the SDVPS images functioned as intended. Although continued validation of the SDVPS in other populations is necessary, the SDVPS may become a new tool by which researchers can begin to systematically and reliably examine reactions to suicide-related content using behavioral and/or experimental paradigms. (PsycINFO Database Record

Positive association between Toxoplasma gondii IgG serointensity and current dysphoria/hopelessness scores in the Old Order Amish: a preliminary study.

Toxoplasma gondii (T. gondii) IgG seropositivity and serointensity have been previously associated with suicidal self-directed violence (SSDV). Although associations with unipolar depression have also been investigated, the results have been inconsistent, possibly as a consequence of high heterogeneity. We have now studied this association in a more homogeneous population, [that is (i.e.) Old Order Amish (OOA)] with previously reported high T. gondii seroprevalence. In 306 OOA with a mean age of 46.1 ± 16.7 years, including 191 (62.4%) women in the Amish Wellness Study, we obtained both T. gondii IgG titers (by enzyme-linked immunosorbent assay [ELISA]), and depression screening questionnaires (Patient Health Questionnaire [PHQ-9] [n = 280] and PHQ-2 [n = 26]). Associations between T. gondii IgG and dysphoria/hopelessness and anhedonia scores on depression screening questionnaires were analyzed using multivariable linear methods with adjustment for age and sex. Serointensity was associated with both current dysphoria/hopelessness (p = 0.045) and current combined anhedonia and dysphoria/hopelessness (p = 0.043), while associations with simple anhedonia and past/lifelong (rather than current) phenotypes were not significant. These results indicate the need for larger longitudinal studies to corroborate the association between dysphoria/hopelessness and T. gondii IgG-titers. Current hopelessness is a known risk factor for SSDV which responds particularly well to cognitive behavioral therapy, and may be a focused treatment target for T. gondii-positive individuals at high-risk for SSDV.

Personal Technology Use and Thwarted Belongingness Among Suicidal Active-Duty Military Personnel.

This study (a) provides descriptive information about the personal technology use of a suicide sample of active-duty military personnel and (b) uses a traditional and a technology-based measure of social connectedness to examine their relation to suicide ideation and behaviors. Higher thwarted belongingness, and therefore lower perceived social connectedness, was associated with higher current and worst suicide ideation and a greater lifetime self-directed violence regardless of intent to die. Higher social connectedness based on personal technology usage was associated with higher current suicide ideation and a higher number of lifetime self-directed violence and suicide attempts.

Self- and other-directed forms of violence and their relationship with lifetime DSM-5 psychiatric disorders: Results from the National Epidemiologic Survey on Alcohol Related Conditions−III (NESARC−III)

A combined history of violence toward self and others has been reported in clinical and incarcerated populations. Psychiatric disorders have been implicated as risk factors. This study examines the lifetime prevalence of this combined violence in the general population and its associations with DSM-5 psychiatric disorders in comparison with other- and self-directed violence. Data from the National Epidemiologic Survey on Alcohol and Related Conditions–III (NESARC–III) were analyzed, including 36,309 U.S. adults ages 18 and older. Violent behavior was defined by suicide attempts; recurrent suicidal behavior; gestures, threats, or self-mutilating behavior (self-directed); and multiple items of violence toward others (other-directed) in four categories: none, self-directed only, other-directed only, and combined self-/other-directed. Multinomial logistic regression examined these violence categories in association with sociodemographics and lifetime DSM-5 psychiatric disorders. Results show that approximately 18.1% of adults reported violent behavior, including self-directed only (4.4%), other-directed only (10.9%), and combined self- and other-directed violence (2.8%). DSM-5 psychiatric disorders significantly associated with the violence typology include alcohol, tobacco, cannabis, and other drug use disorders; mood disorders; posttraumatic stress disorder; and schizotypal, antisocial, and borderline personality disorders. Findings extend the clinical literature regarding the co-occurrence of self- and other-directed violent behaviors to the general population.

Brief report: A network analysis of self-cutting risk among late adolescent girls exposed to dating violence

Adolescent self-directed violence (SDV) is a major public health concern. Adolescent girls exposed to dating violence (DV) are a particularly vulnerable group. Numerous studies have examined the number and type of SDV risk factors, but few examined global patterns of relationships among them. Exploring global patterns of risk is crucial to developing targeted prevention efforts. In this study we applied a network model to identify risk patterns for a common form of SDV, self-cutting, among American adolescent girls (N = 109) with history of DV. Risk factor networks were compared among girls who did/did not endorse lifetime self-cutting. Girls with a history of self-cutting (19%) had a risk factor network characterized by a higher number of associations than girls who did not (test statistic = 0.142; 95% CI = 02-.03). For these girls, the experience of one risk factor is more likely to co-occur with multiple others, thereby potentially compounding effects and unwanted consequences.

Suicide among American Indian/Alaska Native military service members and veterans.

Many American Indian/Alaska Native (AI/AN) communities experience high suicide rates. However, there is little discussion in epidemiological and empirical literature about suicide-related outcomes among AI/AN military service members or veterans. This article briefly reviews the literature on AI/AN suicide and discusses what is known about Native military service member and veteran suicide mortality and self-directed violence. Recent studies suggest high suicide death rates among AI/AN military service members and veterans. Discussion includes the potential for unique cultural protective and risk factors that could inform prevention efforts and some of the novel existing efforts to support AI/AN veterans are reviewed. Given concerning suicide rates among military service members and veterans, it is important for future research to clarify the risk to AI/AN military service members and veterans and how to best develop and implement effective suicide prevention/interventions. (PsycINFO Database Record

The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis

A growing body of research identifies the harmful effects that adverse childhood experiences (ACEs; occurring during childhood or adolescence; eg, child maltreatment or exposure to domestic violence) have on health throughout life. Studies have quantified such effects for individual ACEs. However, ACEs frequently co-occur and no synthesis of findings from studies measuring the effect of multiple ACE types has been done. In this systematic review and meta-analysis, we searched five electronic databases for cross-sectional, case-control, or cohort studies published up to May 6, 2016, reporting risks of health outcomes, consisting of substance use, sexual health, mental health, weight and physical exercise, violence, and physical health status and conditions, associated with multiple ACEs. We selected articles that presented risk estimates for individuals with at least four ACEs compared with those with none for outcomes with sufficient data for meta-analysis (at least four populations). Included studies also focused on adults aged at least 18 years with a sample size of at least 100. We excluded studies based on high-risk or clinical populations. We extracted data from published reports. We calculated pooled odds ratios (ORs) using a random-effects model. Of 11 621 references identified by the search, 37 included studies provided risk estimates for 23 outcomes, with a total of 253 719 participants. Individuals with at least four ACEs were at increased risk of all health outcomes compared with individuals with no ACEs. Associations were weak or modest for physical inactivity, overweight or obesity, and diabetes (ORs of less than two); moderate for smoking, heavy alcohol use, poor self-rated health, cancer, heart disease, and respiratory disease (ORs of two to three), strong for sexual risk taking, mental ill health, and problematic alcohol use (ORs of more than three to six), and strongest for problematic drug use and interpersonal and self-directed violence (ORs of more than seven). We identified considerable heterogeneity (I2 of >75%) between estimates for almost half of the outcomes. To have multiple ACEs is a major risk factor for many health conditions. The outcomes most strongly associated with multiple ACEs represent ACE risks for the next generation (eg, violence, mental illness, and substance use). To sustain improvements in public health requires a shift in focus to include prevention of ACEs, resilience building, and ACE-informed service provision. The Sustainable Development Goals provide a global platform to reduce ACEs and their life-course effect on health. Public Health Wales.

Suicidal Self-Directed Violence Among Homeless US Veterans: A Systematic Review.

A systematic review of the literature was conducted to investigate suicidal self-directed violence and homelessness among US military veterans, and identify existing suicide prevention strategies. In November 2015, MEDLINE, EMBASE, PsycInfo, CINAHL, Web of Science, Cochrane Library, Google, and Google Scholar were searched. Articles published since 1990 investigating self-directed violence among homeless veterans were identified. Data were extracted and synthesized qualitatively. Nineteen observational studies were included. Suicide ideation rates were 1.3% (current), 7.0% (past week), 12.1%-18% (past 30days), and 74% (lifetime). Suicide attempt rates were 0%-6% (past 30days), 30.7%-31.5% (past 5 years), and 15%-46.6% (lifetime). Death by suicide rate was 81.0 per 100,000. No interventional studies to prevent self-directed violence among homeless veterans were identified. Homeless veterans are at risk for self-directed violence, suggesting the need for research to examine preventive strategies. A comprehensive public health approach to suicide prevention needs to focus on vulnerable populations, including homeless veterans.

Access to a Loaded Gun Without Adult Permission and School-Based Bullying

PurposeGun access and bullying are risk factors for sustaining or perpetrating violence among adolescents. Our knowledge of gun access among bullied students is limited. MethodsWe used data on students, aged 12–18 years, from the 2011 and 2013 School Crime Supplement to the National Crime Victimization Survey to assess the association between self-reported bullying victimization (traditional and cyber) and access to a loaded gun without adult permission. Prevalence ratios (PRs) and confidence intervals (CIs) were obtained from multivariable Poisson regression using the Taylor series after controlling for student age, sex, family income, public/private school, and race. ResultsOf 10,704 participants, 4.2% (95% CI: 3.8%–4.6%) reported gun access. Compared with nonbullied students, those who reported traditional bullying (PR = 2.2; 95% CI: 1.7–2.4), cyberbullying (PR = 2.8; 95% CI: 1.6–4.9), and both (PR = 5.9; 95% CI: 4.6–7.7) were more likely to also report gun access. ConclusionsAdolescents who experience bullying, particularly those who report both traditional bullying and cyberbullying, are more likely to report access to a loaded gun without adult permission. These findings highlight the importance of developing interventions focused on these modifiable risk factors for preventing self-directed or interpersonal violence among youth.

Negative Emotions as Risk Factors for Self-Directed Violence and Intimate Partner Violence in Chinese College Students.

In this study, we examined the unique contributions of negative emotions (i.e., anger, depression, and shame) for two different types of self-directed violence (i.e., nonsuicidal self-injury [NSSI] and suicidality) and three different types of intimate partner violence perpetration (i.e., physical, sexual, and psychological violence) in a college sample. We investigated the moderating role of gender in any link between the negative emotions and the violent behaviors. We also examined an association between self-directed violence and intimate partner violence perpetration. We collected the survey data from a convenience sample of 752 Chinese college students (408 women and 344 men) ranging from 18 to 23 years of age. The questionnaires were filled out during class time. Analyses revealed that anger was associated with increased intimate partner physical, sexual, and psychological violence perpetration but not self-directed violence, underscoring its relevance for engaging in violence directed toward others. Our analyses also showed that, conversely, shame was associated with increased NSSI and suicidality but not intimate partner violence. Depression was associated with increased risk of engaging in self-directed violence as well as intimate partner physical and psychological violence. Moderation analysis showed that gender moderates the relationship of shame with NSSI. Women appear more susceptible to NSSI influenced by shame. Furthermore, the results found self-directed violence and intimate partner physical violence perpetration to be associated. The findings highlight the importance of targeting negative emotions in treatment with high-risk individuals. Integrated violence prevention programs would make it possible to treat co-occurring violence against self and intimate others in a more effective way.

1107 SLEEP DISTURBANCE AS A RISK FACTOR FOR NON-SUICIDAL SELF INJURY AND SUICIDAL BEHAVIOUR IN YOUTH.

Introduction: Converging evidence identifies sleep disturbance as an evidence-based risk factor for suicidal behaviour. This relationship has not yet been systematically evaluated in association with a history of non-suicidal self-injury (NSSI). Research is warranted among adolescents given increased vulnerability to sleep disturbances and high risk of suicide attempts. The current investigation sought to examine sleep disturbances among youth with 1) no history of self-directed violence (SDV) (controls), 2) history of NSSI, or 3) history of a suicide attempt (SA). Methods: N=1046 high school students (aged 15–17; 53% female) completed self-report surveys of SDV (with and without suicidal intent), depression, and a range of sleep parameters using: The Sleep Condition Indicator (SCI; Insomnia symptoms), Disturbing Dreams and Nightmare Severity Index (DDNSI), Munch Chronotype Questionnaire (MCQ; sleep efficiency (SE), total sleep time (TST), chronotype), and Hospital Anxiety and Depression Scale. Consistent with suicidal ideation findings, sleep disturbance were hypothesized to be greater among both SDV groups relative to those without such a history. ANCOVA analyses (including HADS as a planned covariate) were employed to examine differences between groups. Results: Youth in groups endorsing past SDV (NSSI=12.2%, SA=5.6%) scored Significantly lower on the SCI (p<0.001), indicating greater insomnia severity than controls (82.2%). SE was poorer (school (p=0.005) and weekend nights (p=0.004)), with shorter school night TST (p=0.003) and greater eveningness observed among those reporting NSSI and SA history (p=0.020). DDNSI-assessed nightmare severity differed significantly between all three groups (p<0.001), with the highest scores observed among those with an SA history. All effects remained when controlling for depression, with the exception of chronotype. Conclusion: Findings revealed significant differences in sleep disturbance between youth with no history of SDV and those reporting NSSI or SA histories. These findings may inform empirically-driven approaches to risk assessment and interventions to enhance prevention of suicide and NSSI.

Suicidal ideation and suicidal self-directed violence following clinician-initiated prescription opioid discontinuation among long-term opioid users.

Little is known about patient outcomes following discontinuation of opioid therapy, which may include suicidal ideation (SI) and suicidal self-directed violence (SSV). The purpose of this study was to examine correlates of SI and non-fatal SSV in a sample of patients discontinued from long-term opioid therapy (LTOT). Five hundred-nine Veterans Health Administration (VHA) patients whose clinicians discontinued them from LTOT were selected from a national cohort of VHA patients who discontinued opioids in 2012. The sample comprised patients with a substance use disorder and matched controls. Patient electronic health records were manually reviewed to identify discontinuation reasons and the presence of SI or SSV in the 12months following discontinuation. Forty-seven patients (9.2%) had SI only, while 12 patients (2.4%) had SSV. In covariate-adjusted logistic regression models, mental health diagnoses associated with having SI/SSV included post-traumatic stress disorder (aOR=2.56, 95% CI=1.23-5.32) and psychotic disorders (aOR=3.19, 95% CI=1.14-8.89). Other medical comorbidities, substance use disorder and pain diagnoses, opioid dose, and benzodiazepine prescriptions were unrelated to SI/SSV. Among patients with a substance use disorder and matched controls, there are high rates of SI/SSV following opioid discontinuation, suggesting that these "high risk" patients may require close monitoring and risk prevention.

Reducing restraint with clozapine in involuntarily admitted patients with schizophrenia

IntroductionIn the entire world, restraint and seclusion are common interventions in psychiatric in-patient settings due to aggressive behavior.ObjectivesOur objective was to test for the immediate anti-aggressive property of clozapine compared to other antipsychotic treatments in an enriched cohort with high rates of restraint during early hospitalization.MethodsWe present a retrospective chart review in all involuntary admissions with schizophrenia during 2011–2014 in Psychiatry and Neurology Hospital, Brasov, Romania. Timing and number of restraints in addition to clinical, demographic and treatment characteristics were extracted. Based on our earlier observation of clinical efficacy of early, fast titration of clozapine, we tested the hypothesis that clozapine treatment was associated with reduced use of restraint, and with longer restraint-free periods.ResultsIn 115 patients with schizophrenia (age = 39.7 ± 11.1 years; male = 59%) involuntarily admitted due to externalized (74.78%) or self-directed violence (25.22%), restraint was used in 89.6%; with a median duration of 3 hours until restraint past admission. Antipsychotics used immediately after hospitalization included haloperidol (70.4%), clozapine (11.3%), olanzapine (10.4%) and other second-generation antipsychotics (7.9%). Comparison of restraint characteristics favored immediate clozapine use with highly reduced rates of restraint (38.5% vs.95.6%. P &lt; 0.001) and significantly extended hours until restraint ([118 h,24 h, 426 h] vs.[3 h,0.25 h, 48 h]; median; 25th, 75th percentile; P &lt; 0.001) relative to the remaining cohort. These effects remained highly significant after controlling for potential moderators of restraint use in multivariate models.ConclusionsThese retrospective data suggest an early anti-aggressive effect of clozapine during the immediate use of clozapine in highly problematic patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.