Self-assembly Technique Research Articles

A facile way of controlling capillary condensation: particle-based crystal

To demonstrate a facile method to control capillary condensation via the design of confined geometric structures, we use a particle self-assembly technique to fabricate porous materials with well-defined pore sizes. Four groups of silica particles were synthesized using the modified Stober method, and these groups of particles were then arranged in closely packed structures. Quantitative predictions of capillary condensation were made based on the Kelvin equation and an approximation of the geometric structures of our closely packed samples. Experimental observations revealed that water uptake at 100% relative humidity reached 40%–50% relative to particle mass across sizes, closely aligning with theoretical predictions for small-particle systems, even though the geometry of some of the confined spaces corresponds to distances smaller than 10 nm. Despite deviation from theoretical predictions that are observed in larger particle systems, and which can be attributed primarily to practical limitations of attainable ordered structures at these scales, this fabrication method shows great potential for the creation of devices that allow facile control of capillary condensation in relevant applications such as vapor capture and humidity control.

S-scheme NiO/C3N5 heterojunctions with enhanced interfacial electric field for boosting photothermal-assisted photocatalytic H2 and H2O2 production

Heterostructured visible-light-responsive photocatalysts represent a prospective approach to achieve efficient solar-to-chemical energy conversion. Herein, we propose a facile self-assembly technique to synthesize NiO nanoparticles/C3N5 nanosheets (NOCN) heterojunctions for hydrogen (H2) evolution catalysis and hydrogen peroxide (H2O2) production under visible light. In this regard, the black NiO nanoparticles (NPs) were tightly anchored on the surface of C3N5 nanosheets (CNNS) to construct S-scheme NOCN heterojunction, enabling efficient charge separation and high redox capability. Obtained results elucidated that the incorporated NiO NPs significantly promote light-harvesting efficiency and photo-to-thermal capacity over the NOCN composites. The enhanced photothermal effect facilitates the charge carrier transfer rate across the heterojunction and boosts the surface reaction kinetics. Accordingly, the photocatalytic performances of CNNS for H2 release and H2O2 production can be manipulated by introducing NiO NPs. The modified photocatalytic properties of NOCN composites are ascribed to the synergistic effects of all integrated components and the S-scheme heterojunction formation. Impressively, the high H2 evolution photocatalysis efficiency of NOCN nano-catalysts in seawater certifies their potential environmental applicability. Among all, the 12-NOCN nano-catalyst exhibits a higher photocatalytic efficiency for H2 release (112.2 μmol∙g−1∙h−1) and H2O2 production (91.2 μmol∙L−1∙h−1). Besides, the 12-NOCN nano-catalyst reveals excellent recyclability and structural stability. Additionally, the possible mechanism for photothermal-assisted photocatalysis is proposed. This work affords a feasible pathway to design photothermal-assisted S-scheme heterojunctions for diverse photocatalytic applications.

Self-assembly of modified cellulose nanocrystals on flexible fabric via hydrophobic force induction for versatile applications

Over the years, there has been a proliferation of superhydrophobic fabrics constructed by self-assembly techniques. However, most of these suffer from poor mechanical durability and chemical stability, while the complexity of the process severely limits their practical application in textiles with special functionalities. In this study, We have built a self-assembly coating with many advantages such as large specific surface area, ultra-fast, high particle utilization, and dense and homogeneous alignment of particles. We modified cellulose nanocrystals (m-CNCs) using a variety of hydrophobic monomers, and the modified cellulose nanocrystals were suspended in a solution of isopropanol-containing end-hydroxy polysiloxane (MSDS) and hydrogen-containing polysiloxane (PHMS). The silicone system was used to treat a cotton fabric to obtain a superhydrophobic fabric by hydrophobically inducing modified cellulose nanocrystals to self-assemble on the fibre surface. Unlike many previous studies, owing to the m-CNC particles being chemically bonded between the multilayer nanostructure and the fabric, the coating had excellent mechanical durability and remained superhydrophobic after abrasion by sandpaper or peeling with tape. In addition, the nanostructure of the coating surface trapped air in the surface pores, preventing the penetration of H+, Na+, Cl−, and OH− in liquids; thus, the fabric remained hydrophobic both under extreme solution conditions and after soaping cycle tests, showing excellent stability and cycling ability. At the same time, the breaking strength of the fabric is improved after finishing, and the wearability is almost unchanged. Coated fabrics have good potential in the fields of self-cleaning, anti-staining, oil absorption, and oil–water separation.

Micropatterning of biologically derived surfaces with functional clay nanotubes

ABSTRACT Micropatterning of biological surfaces performed via assembly of nano-blocks is an efficient design method for functional materials with complex organic–inorganic architecture. Halloysite clay nanotubes with high aspect ratios and empty lumens have attracted widespread interest for aligned biocompatible composite production. Here, we give our vision of advances in interfacial self-assembly techniques for these natural nanotubes. Highly ordered micropatterns of halloysite, such as coffee rings, regular strips, and concentric circles, can be obtained through high-temperature evaporation-induced self-assembly in a confined space and shear-force brush-induced orientation. Assembly of these clay nanotubes on biological surfaces, including the coating of human or animal hair, wool, and cotton, was generalized with the indication of common features. Halloysite-coated microfibers promise new approaches in cotton and hair dyeing, medical hemostasis, and flame-retardant tissue applications. An interfacial halloysite assembly on oil microdroplets (Pickering emulsion) and its core–shell structure (functionalization with quantum dots) was described in comparison with microfiber nanoclay coatings. In addition to being abundantly available in nature, halloysite is also biosafe, which makes its spontaneous surface micropatterning prospective for high-performance materials, and it is a promising technique with potential for an industrial scale-up.

Optical fiber immunosensor based on nanobody for the detection of carcinoembryonic antigen

We engineered two highly specific, label-free optical fiber immunosensors incorporating innovative nanobodies as biological probes. These sensors, named the graphene oxide (GO) immunosensor and gold nanoparticles (GNP) immunosensor, leverage GO and GNP as bio-sensitive materials for the unlabeled detection of carcinoembryonic antigen (CEA). By employing a layer-by-layer self-assembly technique, we precisely coated the sensitive material onto the optical fiber microstructure, subsequently adsorbing nanobodies onto the coated surface. The detection mechanism hinges on monitoring refractive index changes induced by CEA adsorption onto nanobodies, distinguishing them from changes induced by other analytes. Experimental results showcase the sensitivities of the GO immunosensor and GNP immunosensor at 15.1 nm/nM and 20.2 nm/nM, respectively, with corresponding lower detection limits of 0.05 nM and 0.02 nM. Notably, both biosensors exhibit outstanding specificity, operate label-free, and enable rapid detection of low concentrations of CEA. This proposed optical immunosensor holds significant promise as a biophotonic platform for clinical diagnostics, offering advancements in medical applications.

Formation and Application of Polymer Spherulite-like Patterns of Halloysite Nanotubes by Evaporation-Induced Self-Assembly.

Halloysite nanotubes (HNTs) are one-dimensional clay nanomaterials featuring distinct tubular structures and unique surface charges. HNTs can readily form ordered assembly structures under specific conditions, which shows significant potential applications in optical and biological fields. In this study, sodium hexametaphosphate (SHMP) was employed as a stabilizer to prepare polymer spherulite-like patterns via the evaporation-induced self-assembly (EISA) technique. The incorporation of SHMP enhanced the repulsion force among the nanotubes and the surface potential, which facilitated the orderly deposition of HNTs. The influence of HNT concentration, SHMP concentration, drying temperature, and substrate on the polymer spherulites-like pattern has been investigated in detail. The optimal conditions were 10 wt % HNT dispersion, 0.6 wt % SHMP concentration, 30 °C as drying temperature, and glass substrates. In addition, by changing the droplet volume and shape of the three-phase contact line, patterns of different sizes and shapes can be achieved. Bovine serum albumin or metal salt compounds were incorporated into the dispersion of SHMP-modified HNTs, which altered the charge and the self-assembled patterns with different area ratios. Thus, this technology can be utilized for the analysis and comparison of protein and metal ion concentration accurately. This study creates the correlation between the structural parameters and the preparation process involved in creating polymer spherulite-like patterns of modified HNTs and offers fresh insights into potential applications for the self-assembly of HNT droplets in the realms of anticounterfeiting and solution concentration analysis.

Multifunctional Bagasse Foam with Improved Thermal Insulation and Flame Retardancy by a Borax-Induced Self-Assembly and Ambient Pressure Drying Technique.

Cellulose foams are considered an effective alternative to plastic foam, because of their advantages of low density, high porosity, low thermal conductivity, and renewable nature. However, they still suffer from complex processing, poor mechanical properties, and flammability. As an agricultural waste, bagasse is rich in cellulose, which has attracted much attention. Inspired by the fact that borate ions can effectively enhance the strength of plant tissue by their cross-linking with polysaccharides, the present work designs and fabricates a series of multifunctional bagasse foams with robust strength and improved thermal insulation and flame retardancy via a unique borax-induced self-assembly and atmospheric pressure drying route using bagasse as a raw material, borate as a cross-linking agent, and chitosan as an additive. As a result, the optimized foam exhibits a high porosity (93.5%), a high hydrophobic water contact angle (150.4°), a low thermal conductivity (63.4 mW/(m·K) at 25 °C), and an outstanding flame retardancy. The present study provides a novel and inspiring idea for large-scale production of cellulose foams through an environmentally friendly and cost-effective approach.

Self-assembly of Co/Pt stripes with current-induced domain wall motion towards 3D racetrack devices

Modification of the magnetic properties under the induced strain and curvature is a promising avenue to build three-dimensional magnetic devices, based on the domain wall motion. So far, most of the studies with 3D magnetic structures were performed in the helixes and nanowires, mainly with stationary domain walls. In this study, we demonstrate the impact of 3D geometry, strain and curvature on the current-induced domain wall motion and spin-orbital torque efficiency in the heterostructure, realized via a self-assembly rolling technique on a polymeric platform. We introduce a complete 3D memory unit with write, read and store functionality, all based on the field-free domain wall motion. Additionally, we conducted a comparative analysis between 2D and 3D structures, particularly addressing the influence of heat during the electric current pulse sequences. Finally, we demonstrated a remarkable increase of 30% in spin-torque efficiency in 3D configuration.

Optical pH Sensor Based on a Long-Period Fiber Grating Coated with a Polymeric Layer-by-Layer Electrostatic Self-Assembled Nanofilm.

An optical fiber pH sensor based on a long-period fiber grating (LPFG) is reported. Two oppositely charged polymers, polyethylenimine (PEI) and polyacrylic acid (PAA), were alternately deposited on the sensing structure through a layer-by-layer (LbL) electrostatic self-assembly technique. Since the polymers are pH sensitive, their refractive index (RI) varies when the pH of the solution changes due to swelling/deswelling phenomena. The fabricated multilayer coating retained a similar property, enabling its use in pH-sensing applications. The pH of the PAA dipping solution was tuned so that a coated LPFG achieved a pH sensitivity of (6.3 ± 0.2) nm/pH in the 5.92-9.23 pH range. Only two bilayers of PEI/PAA were used as an overlay, which reduces the fabrication time and increases the reproducibility of the sensor, and its reversibility and repeatability were demonstrated by tracking the resonance band position throughout multiple cycles between different pH solutions. With simulation work and experimental results from a low-finesse Fabry-Perot (FP) cavity on a fiber tip, the coating properties were estimated. When saturated at low pH, it has a thickness of 200 nm and 1.53 ± 0.01 RI, expanding up to 310 nm with a 1.35 ± 0.01 RI at higher pH values, mostly due to the structural changes in the PAA.

Ag@Au yolk shells decorated onto silica spheres for enhanced plasmonic applications

Silica surfaces covered with a homogenous layer of metal nanoparticles exhibit superior plasmonic properties when compared with pristine colloidal counterparts, as they have higher scattering probability with enhanced potential utility. Precise galvanic replacement reactions performed on such sacrificial templates are of great interest. Herein, we demonstrate the robust formation of Ag@Au yolk shells decorated onto the dielectric silica spheres via a direct one-step galvanic replacement procedure, evidently initiating the deposition of Au onto low surface energy Ag facets (prefixed onto the silica spheres), resulting in a disjointed framework of compact dealloyed metal lobes, wherein their facets remain smooth enough with a high degree of crystallinity and exhibit maximal porosity. Our combined spectroscopic data analyses corroborate the plausible mechanism governing solely the formation of Ag@Au core-shell onto the silica spheres rather than their hollow counterparts. Furthermore, we made the respective monolayer films using the well-known air-water interface self-assembly technique, which allowed us to easily decorate different substrates with a uniform array of these surface-coupled metal nanoparticles. Enhanced refractive index (RI) sensing applications based on the sensitivity and FOM (figure of merit) calculations demonstrate the versatile nature of our synthetic protocol for direct synthesis of optical metamaterials along with their intriguing light-matter interactions, in general. Also, the plasmonic vector field of 2-D assembled nanoparticle monolayer displays intrigued SERS enhancement of crystal violet dye when compared with their respective drop-casted films, thus establishing a novel method for producing diverse meta-structures based efficient SERS substrates with promising applications in ultrasensitive chemical and biological sensing.

Tissue Engineering for Penile Reconstruction.

The penis is a complex organ with a development cycle from the fetal stage to puberty. In addition, it may suffer from either congenital or acquired anomalies. Penile surgical reconstruction has been the center of interest for many researchers but is still challenging due to the complexity of its anatomy and functionality. In this review, penile anatomy, pathologies, and current treatments are described, including surgical techniques and tissue engineering approaches. The self-assembly technique currently applied is emphasized since it is considered promising for an adequate tissue-engineered penile reconstructed substitute.

Integrating Low-Stack Photonic Crystals with the Honeycomb-like Structural Framework to Enhance the Photovoltaic Performance in Perovskite Solar Cells.

An inverse opal structure of SnO2 with a honeycomb morphology is introduced as the framework for the attached perovskite materials and functional layers in the hybrid perovskite-based solar cells simultaneously. Three different pore sizes of polystyrene microsphere layers, with diameters of 350, 480, and 600 nm, were fabricated through a vertical self-assembly vaporization technique. The polystyrene (PS) layer served as the sacrificial template for the inverse opal structure. By controlling the spinning parameters, the inverse opal-structured SnO2 layer was used to constrain them into a single-layer stacking structure. These layers with varying pore sizes were subsequently applied onto a dense electron transport layer that is in contact with the perovskite layer. A carbon electrode is used as photovoltaic solar cells. The major benefits of this approach were systematically analyzed through structural characterizations and various means. The semiphotonic crystal layer induces modulation effects, resulting in increased light absorption and surface area, which leads to a substantial increase in short-circuit density. By studying the electrochemical properties in the dark to exclude the influence of optical effects, we attribute the slight increase in the fill factor to the increased surface area, which enhances carrier transport. Among the different layers, the inverse opal layer prepared with 480 nm polystyrene microspheres displayed superior photovoltaic performance parameters due to its appropriate surface area and relatively higher light absorption. The power conversion efficiency of the MAPbI3 perovskite solar cell showed a relative enhancement of 55%. Additionally, aging tests demonstrated that devices with the additional structural layer exhibited good endurance under conventional atmospheric conditions after 1440 h of aging.

Constructing a 3D Bi2WO6/ZnIn2S4 direct Z-scheme heterostructure for improved photocatalytic CO2 reduction performance

Developing efficient heterojunction photocatalysts with enhanced charge transfer and reduced recombination rates of photogenerated carriers is crucial for harnessing solar energy in the photocatalytic CO2 reduction into renewable fuels. This study employed electrostatic self-assembly techniques to construct a 3D Bi2WO6/ZnIn2S4 direct Z-scheme heterojunctions. The unique 3D structure provided abundant active sites and facilitated CO2 adsorption. Moreover, the optimized Bi2WO6/ZnIn2S4 composite demonstrated an impressive CH4 yield of 19.54 μmol g−1 under 4 h of simulated sunlight irradiation, which was about 8.73 and 16.30-fold higher than pure ZnIn2S4 and Bi2WO6. The observed enhancements in photocatalytic performance are attributed to forming a direct Z-scheme heterojunction, which effectively promotes charge transport and migration. This research introduces a novel strategy for constructing photocatalysts through the synergistic effect of morphological interface modifications.

A Comprehensive Review of Self-Assembly Techniques Used to Fabricate as DNA Origami, Block Copolymers, and Colloidal Nanostructures

Abstract: Self-assembly techniques play a pivotal role in the field of nanotechnology, enabling the spontaneous organization of individual building blocks into ordered nanostructures without external intervention. In DNA origami, the design and synthesis of DNA strands allow for precise folding into complex nanoarchitectures. This technique holds immense promise in nanoelectronics, nanomedicine, and nanophotonics, offering nanoscale precision and versatility in structural design. Block copolymers represent another fascinating self-assembly system, driven by phase separation and microdomain formation. Understanding and controlling the self-assembly behavior of block copolymers enable applications in nanolithography, nanopatterning, and nanofabrication, owing to their ability to generate well-defined nanostructures. Colloidal assembly is a versatile and powerful technique for fabricating ordered nanostructures and materials with precise control over their properties. The process involves the spontaneous arrangement of colloidal particles into well-defined structures at the microscale or larger, driven by interparticle interactions, Brownian motion, and entropic effects. As research and technology continue to progress, colloidal assembly holds promising opportunities for creating novel materials with applications in diverse fields, contributing to advancements in nanotechnology, optics, electronics, and biomedicine. The continuous exploration and development of colloidal assembly techniques will undoubtedly open new avenues for innovation and impact various areas of science and technology in the future. This review article provides a comprehensive overview of various self-assembly techniques used to fabricate nanostructures, focusing on DNA origami, block copolymers, and colloidal assembly. With a focus on DNA origami in particular, its uses in drug administration, biosensing, nanofabrication, and computational storage are introduced. There is also a discussion of the potential and difficulties involved in assembling and using DNA origami.

Preparation of PMIA loose nanofiltration membrane with electrostatic layer-by-layer self-assembled for dye/salt filtration

Poly (m-phenylene isophthalamide)-based loose nanofiltration membranes were fabricated by electrospinning and subsequential electrostatic layer by-layer self-assembly methods, and the polyelectrolyte multilayers (PEMs) generated by polyacrylic acid (PAA) and polyethyleneimine (PEI) were adopted to contribute the surface functional layer of nanofiber membranes. The incidences of spraying parameter and nano-SiO2 content on the morphology, chemical constitution and dyes separation performance of PEMs functional layer was investigated, respectively. The results showed that the construction of the PEMs functional layer could obviously enhance the Congo red (CR) filtration efficiency by increasing the rejection from 4.9% to 99.8% and improve the surface hydrophilicity by reducing the water contact angle (WCA) from 90.1° to 51.8°. Nano-SiO2 is introduced as a filler to regulate the assembly density of PEMs functional layers, the prepared PEMs/PMIA/SiO2 membrane achieved a relatively stable permeation flux (22.9 L·m−2·h−1), and maintained high separation efficiency of CR/NaCl solution, revealing the excellent dye desalination performance, which exhibited a potential for the dye/salt wastewater treatment. In particular, we offered a new method to prepare loose nanofiltration (LNF) membranes by electrospinning and electrostatic self-assembly technique with accurate separation of inorganic salts and dye molecules.

Enhancement of Photoluminescence Properties via Polymer Infiltration in a Colloidal Photonic Glass

Photonic glasses (PGs) based on the self-assembly of monosized nanoparticles can be an effective tool for realizing disordered structures capable of tailoring light diffusion due to the establishment of Mie resonances. In particular, the wavelength position of these resonances depends mainly on the morphology (dimension) and optical properties (refractive index) of the building blocks. In this study, we report the fabrication and optical characterization of photonic glasses obtained via a self-assembling technique. Furthermore, we have demonstrated that the infiltration of these systems with a green-emitting polymer enhances the properties of the polymer, resulting in a large increase in its photoluminescence quantum yield and a 3 ps growing time of the photoluminescence time decay Finally, the development of the aforementioned system can serve as a suitable low-cost platform for the realization of lasers and fluorescence-based bio-sensors.

A novel mussel-inspired desensitizer based on radial mesoporous bioactive nanoglass for the treatment of dentin exposure: An in vitro study

ObjectivesThe dentin exposure always leads to dentin hypersensitivity and the acid-resistant/abrasion-resistant stability of current therapeutic approaches remain unsatisfatory. Inspired by the excellent self-polymerization/adherence activity of mussels and the superior mineralization ability of bioactive glass, a novel radial mesoporous bioactive nanoglass coated with polydopamine (RMBG@PDA) was developed for prevention and management of dentin hypersensitivity. MethodsRadial mesoporous bioactive nanoglass (RMBG) was synthesized by the sol-gel process combined with the cetylpyridine bromide template self-assembly technique. RMBG@PDA was synthesized by a self-polymerization process involving dopamine and RMBG in an alkaline environment. Then, the nanoscale morphology, chemical structure, crystalline phase and Zeta potential of RMBG and RMBG@PDA were characterized. Subsequently, the ion release ability, bioactivity, and cytotoxicity of RMBG and RMBG@PDA in vitro were investigated. Moreover, an in vitro experimental model of dentin hypersensitivity was constructed to evaluate the effectiveness of RMBG@PDA on dentinal tubule occlusion, including resistances against acid and abrasion. Finally, the Young's modulus and nanohardness of acid-etched dentin were also detected after RMBG@PDA treatment. ResultsRMBG@PDA showed a typical nanoscale morphology and noncrystalline structure. The use of RMBG@PDA on the dentin surface could effectively occlude dentinal tubules, reduce dentin permeability and achieve excellent acid- and abrasion-resistant stability. Furthermore, RMBG@PDA with excellent cytocompatibility held the capability to recover the Young's modulus and nanohardness of acid-etched dentin. ConclusionThe application of RMBG@PDA with superior dentin tubule occlusion ability and acid/abrasion-resistant stability can provide a therapeutic strategy for the prevention and the management of dentin hypersensitivity.

A stable delivery system for curcumin: Fabrication and characterization of self-assembling acylated kidney bean protein isolate nanogels

The construction of protein-based nano-gels as curcumin delivery system effectively enhances the stability and bioavailability of curcumin. In this study, acylation modification and self-assembly techniques were jointly employed to construct acylated kidney bean protein isolate (AKBPI)-nanogels. Optimal conditions for AKBPI-nanogels were determined to be pH 7, concentration of 2 mg/mL, and temperature at 90℃ for 30 min. The optimized AKBPI-nanogels exhibited excellent uniformity as evidenced by decreasing average particle size (137.35 nm) and polydispersity index (0.38). Acylation enhanced the intermolecular interactions within the nanogel by reducing the polarity of tyrosine microenvironment and free sulfhydryl groups. AKBPI-nanogels demonstrated remarkable characteristics in terms of pH sensitivity, salt concentration, and storage tolerance. The curcumin-loaded AKBPI-nanogels exhibited an encapsulation efficiency of 92.30 % and maintained high antioxidant activity. In simulated gastrointestinal digestion, AKBPI-nanogels facilitated the controlled release and higher bioavailability of curcumin. Therefore, AKBPI-nanogels can be a stable tool for delivering curcumin.

Enhancing osseointegration of titanium implants through MC3T3-E1 protein-gelatin polyelectrolyte multilayers.

Titanium and its alloys have found extensive use in the biomedical field, however, implant loosening due to weak osseointegration remains a concern. Improved surface morphology and chemical composition can enhance the osseointegration of the implant. Bioactive molecules have been utilized to modify the surface of the titanium-based material to achieve rapid and efficient osseointegration between the implant and bone tissues. In this study, the bioactive substance MC3T3-E1 protein-gelatin polyelectrolyte multilayers were constructed on the surface of the titanium implants by means of layer-by-layer self-assembly to enhance the strength of the bond between the bone tissue and the implant. The findings of the study indicate that the layer-by-layer self-assembly technique can enhance surface roughness and hydrophilicity to a considerable extent. Compared to pure titanium, the hydrophilicity of TiOH LBL was significantly increased with a water contact angle of 75.0 2.4°. The modified titanium implant exhibits superior biocompatibility and wound healing ability upon co-culture with cells. MC3T3-E1 cells were co-cultured with TiOH LBL for 1, 3, and 5 days and their viability was higher than 85%. In addition, the wound healing results demonstrate that TiOH LBL exhibited the highest migratory ability (243 ± 10 μm). Furthermore, after 7 days of osteogenic induction, the modified titanium implant significantly promotes osteoblast differentiation.

Self-assembled coating with a metal-polyphenolic network for intraocular lens modification to prevent posterior capsule opacification

Posterior capsule opacification (PCO) is a main complication after cataract surgery and intraocular lens (IOLs) implantation and is attributed to residual lens epithelial cells (LECs) migrating to the IOL surface and posterior capsules. IOL surface modification has been a newly-developing research filed in recent years; however, the applicability and economical acquisition of modified materials remain unsolved. In this study, we first applied a metal-polyphenolic network coating with a self-assembly technique on the IOL surface by using tannic acid (TA) combined with AlCl3, which are easily acquire and applying on the IOL surface to solve the IOL transmittance affair. Using wound healing and Transwell assay to verify AZD0364 inhibits cell migration ( P < 0.05), the lipopolysaccharide-induced macrophage inflammation model to verify pterostilbene (PTE) inhibits the inflammatory reaction ( P < 0.01). By optimizes its self-assembly coating parameters and calculating its drug release kinetics, we successfully loaded these two drugs on the coating, named TA (AZD0364/PTE) IOL. Its surface morphology characteristics were analyzed by scanning electron microscope, x-ray photoelectron spectrometer and water contact angle. The optical performance was carefully investigated by optical instruments and equipment (n= 3). The in vitro results showed that TA (AZD0364/PTE) IOL can significantly inhibit cell adhesion and acute inflammation (n= 3, P < 0.0001). Importantly, after in vivo implantation for 28 d with eight rabbits PCO models in two groups, the TA (AZD0364/PTE) IOL group maintained clear refracting media and decreased the inflammatory reaction compared with the original IOL group ( P < 0.05). This study provides a new applicable and economical strategy for preventing PCO and offers a reference for the next generation of IOLs that benefit cataract patients.