Depending on the developments in technology and information, paper-pencil tests leave their place for computerized adaptive tests (CATs). CAT is widely used in the field of health, mainly in psychiatry. Many item response theory models have been proposed in the literature regarding the use of response time focusing on item difficulty and personal characteristics by ignoring the multidimensional interactions, therefore these results may cause bias in estimates of individual ability levels. The present simulation study was conducted to compare the performance of CAT applications of the effort-moderated item response theory (EM-IRT) model, which is based on response time, and the three-parameter logistic (3PL) model. While simulating CAT with the EM-IRT model and the 3PL model, the hybrid method was used for ability estimation and maximum Fisher information (MFI) was used for item selection. The CAT process proceeded until the standard error of the estimation was <0.3 and <0.5, or all items in the item bank were used. The number of individuals was specified as 1000, while the number of items was changed to 50, 100, and 250. All six scenarios were repeated 1000 times. With the increase in the number of items and the decrease in the standard error as a stopping criterion, consistent results were obtained with true ability levels in both methods. The CAT with the EM-IRT model estimated true ability level slightly lower than CAT with the 3PL model. The EM-IRT model enables measuring the response time that could yield additional data to the physician about the mental and cognitive condition of the patient. The CAT method can be a promising method of telemedicine in the era of the pandemic.