AbstractSelective removal of CO from the effluent streams in real‐life chemical processes is of great importance in many different fields of industry. Until now it remains challenging to use non‐precious metal oxides to selectively remove CO at low temperatures from real‐life chemical effluent with complex compositions. Herein, a series of binary and ternary transition metal oxide catalysts were prepared by co‐precipitation method and employed for the preferential removal of CO in the effluent stream (off‐gas) of propane selective oxidation. It was found that the CuO−CeO2−based mixed oxide catalyst exhibited the best CO removal performance, wider operating temperature window and higher resistance to the inhibition of hydrocarbons, H2O and CO2. The presented catalyst showed high potential for selective removal of CO in the off‐gas stream containing CO2, H2O and various hydrocarbons.