Selective Capture Research Articles

Polydopamine- and MOFs-based molecularly imprinted microfiltration membranes in syringe filter for selective capture of thiamphenicol, florfenicol and chloramphenicol in milk samples

In this study, molecularly imprinted microfiltration membranes (MIMFMs) based on polydopamine and metal–organic framework were innovatively proposed, and successfully prepared for capturing thiamphenicol, florfenicol and chloramphenicol from milk samples through syringe filter device. The provision of PDA and coupling of MOF particles enabled the filter membranes to have great permeability and binding capacity. Cleverly, hydrophilicity and heightened rebinding selectivity (IF = 2.42) of filter membranes was provided using two functional monomers (methacrylate and acrylamide), and microfiltration-grade composite membranes were generated by adjusting the imprinting polymerization time. The combination of the selective filter membranes and the syringe filter devices can effectively simplify the operation process, minimize the extraction time and reduce the tested sample volume. The method was validated by coupling with ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and obtained a good correlation (r2 > 0.99). The limit of detection (LOD) of three analytes was 0.0800–0.6583 µg kg−1 and the mean recovery ranged from 85.5% to 91.2% within relative standard deviations (RSDs) less than 8.2%. Finally, an effective MIMFMs-UHPLC-MS/MS method was established for the recognition and detection of three amphenicol antibiotics in milk samples. The MIMFMs filtration technique offered in this work provides valuable science references and potential application prospects for complicated sample pretreatment.

Ti3C2Tx MXene -facilitated non-selective trapping effect: Efficient SERS detection of exosomal PD-L1

Biosensors developed through a sandwich approach have demonstrated favorable detection performance for exosomal programmed cell death 1 ligand 1 (ExoPD-L1) detection. However, the reported PD-L1 antibodies, peptides, and aptamers utilized in these biosensors typically bind to the extracellular region, with overlapping binding sites that severely constrain the fabrication of biosensors. In this study, we present a simple approach to specifically identify and analyze ExoPD-L1 through the non-selective trapping effect of Ti3C2TX (X=-O, -F, -OH) MXene on exosomes via the formation of Ti–O–P complexation, and the selective capture of peptide-functionalized Au@MPBA (4-Mercaptophenylboronic acid) @SiO2 surface enhanced Raman scattering (SERS) tags on ExoPD-L1. The biosensor delivered a both hypersensitive and reliable performance in exosome detection with a low limit of detection (20.74 particles/mL) in the linear range of 102 to 5×106 particles/mL. Furthermore, the biosensor demonstrated excellent stability and interference resistance in detecting ExoPD-L1 in clinical serum samples, enabling the easy differentiation of breast cancer patients from healthy controls. This work provides new insights into the design of biosensors for exosome detection and can serve as a replicable template for sandwich immunoassay detection for other types of sensors, including but not limited to SERS.

New and simple synthetic strategy for two‐dimensional ultra‐microporous aromatic framework for selective uranium capture in liquid

AbstractUranium is a key element to improve nuclear energy demands, and thereby the extraction of uranium from seawater is a strategic way to address uranium sustainability. Herein, a novel two‐dimensional porous aromatic framework (AO‐PAF), which possesses an ultra‐microporous architecture with an ordered structure, excellent stability and selectivity of uranium extraction from a liquid phase. AO‐PAF shows excellent uranium adsorption capacities of 637 (mg/g) and 3.22 (mg/g) in simulated and natural seawater attributable to the selective uranium coordinating groups on highly accessible pores on the walls of open channels. In addition, benefiting from the super‐hydrophilicity due to the presence of amidoxime groups attributes high selectivity and ultrafast kinetics with an uptake rate of 0.43 ± 0.03 (mg/g·day) and allowing half‐saturation within 1.35 ± 0.09 days. This strategy demonstrates the potential of PAF not only recovery of uranium and can be extended for other applications by sensible planning of target ligands.

Trace SO2 Gas Capture in Stable 3D Viologen Ionic Porous Organic Framework Microsphere.

Eliminating trace sulfur dioxide (SO2) using nanoporous adsorbents is industrially preferred yet of great challenge due to the competitive adsorption of CO2. Herein, we reported a highly stable 3D viologen porous organic framework (Viologen-POF) microsphere via one pot polymerization reaction of 4,4'-bipyridine and tetrakis(4-(bromomethyl)phenyl)methane. Compared to the previously reported irregular POF particles, viologen-POF microsphere shows better mass transfer uniformity. Owing to the intrinsic separated positive and negative electric charges center in viologen-POF microspheres, it exhibits excellent SO2 selective capture performance, which can be collaboratively confirmed by static single-component gas adsorption, time-dependent adsorption rate, and multicomponent dynamic breakthrough experiments. Viologen-POF exhibits high SO2 absorption capacity (1.45 mmol g-1) at ultralow pressure of 0.002 bar and high SO2/CO2 selectivity of 467 at 298 K and 100 kPa (SO2/CO2, 10/90, v/v). The theoretical calculations based on density functional theory (DFT) and DMol3 modules in Material Studio (MS) were also performed to elucidate the adsorption mechanism of viologen-POF toward SO2 at the molecular level. This study represents a new type of viologen porous framework microsphere for trace SO2 capture, which will pave the way on the applications of ionic POF for toxic gas adsorption and separation.

Ion-imprinted magnetic adsorbents for the selective capture of Cu(II) and their cascade application as heterogeneous recyclable catalysts for Ullmann and Glaser coupling reactions

The selective capture and efficient reuse of Cu(II) from contaminated seawater requires a multifunctional adsorbent with a high Cu(II) selectivity and magnetic properties to facilitate recycling. Moreover, the cascade application of the recycled adsorbent is important but has not been extensively investigated. Accordingly, in this study, ion-imprinted magnetic adsorbents, particularly, copper ion-imprinted polymers (Fe3O4@mSiO2@CIIP) were prepared using magnetic mesoporous silica microspheres (Fe3O4@mSiO2) as carriers, with organosilicon containing hydroxyl and Schiff bases as the polymer backbone to selectively collect Cu(II) from aqueous media. The adsorption isotherms, kinetics, selectivity, and mechanisms were examined under various adsorption conditions. Fe3O4@mSiO2@CIIP-2 shows high selectivity and fast adsorption kinetics, and the equilibrium adsorption amount of Cu(II) is 263.2 mg/g within 30 min. The pseudo-second-order model and the Langmuir model are supported by the adsorption kinetics and isotherms, respectively. Particularly, the adsorption amount of Fe3O4@mSiO2@CIIP-2 could be reused eight times without substantial loss. Additionally, specific functional monomers bound to Fe3O4@mSiO2@CIIP-2 could both selectively adsorb Cu and serve as functional ligands for catalysts that can heterogeneously catalyze the Ullmann and Glaser coupling reactions after adsorbing Cu(II).

Permanent his bundle pacing: Description and comparison of four implantation techniques.

Permanent His bundle pacing (HBP) is the most physiological pacing modality, and new implantation systems are now available. The aim of the present study was to describe and compare four different techniques to perform HBP. We included all consecutive patients who underwent a HBP attempt in our initial experience between June 2020 and May 2022. The success and characteristics of the procedure were compared among four implantation techniques: the Biotronik Selectra 3D sheath with Solia S60 lead (Selectra 3D), the Boston Scientific Site Selective Pacing Catheter with Ingevity lead (SSPC), the Abbott steerable stylet locator with Tendril lead (Locator), and the use of a standard stylet manually pre-shaped with a conventional pacing lead (Curved stylet). Ninety-eight patients (median age 79 years [interquartile range, 73-83], 83% men) were identified. The Selectra 3D technique was used in 43 procedures, SSPC in 26, Locator in 18 and Curved stylet in 11. The groups had similar clinical characteristics. Overall, procedural success was achieved in 91 patients (93%) with similar proportions among groups (p=.986). Fluoroscopy and procedural times were 6.0 (4.4-8.5) and 60 (45-75) min, respectively, without significant differences (p=.333 and p=.790). The rate of selective capture, the pacing threshold, and the paced QRS duration were also comparable. There was one pre-discharge HBP lead dislodgment (1%) that required implant revision. In our experience, four techniques for HBP achieved comparable results in terms of safety and effectiveness. The availability of different systems may lead to widespread use of physiological pacing.

Fabricating self-templated and N-doped hierarchical porous carbon spheres via microfluidic strategy for enhanced CO2 capture

N-doped porous biochar is a promising material for CO2 capture due to its easy regeneration and high CO2 selectivity. In this study, a new strategy was proposed to design monodisperse porous carbon spheres by microfluidics system with chitosan in-situ grow ZIF-8, utilizing ZIF-8 as a self-sacrificing template and nitrogen dopant. The mesoporous volume and N content of carbon spheres can be adjusted through the ZIF-8 content in the microfluidic system and carbonization temperature, within 0.01 ∼ 0.48 cm3/g and 3.23 ∼ 19.25%, respectively. The optimum sample (CZ2-900) exhibited superior CO2/N2 selectivity at 40. Adsorption kinetics and diffusion resistance indicated that CO2 adsorption in CZ2-900 is controlled by the process of CO2 diffusion from the surface of the basic site to mesopores. This was the first attempt at using a microfluid chip to grow ZIF-8 in chitosan skeleton and pyrolysis approach to synthesize N-doped porous carbon sphere where both additional template agent and activator are non-used, revealing the potential of microfluidic technology for the precise synthesis of highly selective CO2 capture materials.

Selective capture of rare earth mineral particles in Bayan Obo by matrix parameters in superconducting magnetic separation

The rare earth minerals in Bayan Obo are poor, fine, scattered and variegated, so it is very difficult to achieve efficient separation. Superconducting magnetic separation technology is an efficient separation technology for refractory minerals. In this paper, the magnetic field induced by a matrix in a superconducting magnetic field is studied based on a finite element method and a separate numerical calculation method, and a model for the trajectories of rare earth mineral particles in Bayan Obo is obtained. The matching relationship between the matrix parameters and the capture radius is obtained through model calculation, as is the optimal capture radius and capture efficiency. The results show that the magnetic field gradient and magnetic field force decrease with increasing distance from the surface of the matrix and that the critical distance of the magnetic field induced by the matrix is 1.5 times the diameter of the matrix. The particle capture radius and capture efficiency are inversely proportional to the matrix diameter. When the matrix diameter is 0.06 mm, the capture efficiency is higher than at other diameters. The theoretical capture efficiency of rare earth mineral particles of size 20–38 µm is approximately 98%, but for particles below 10 µm, the capture efficiency is only 30%. The research results provide a quantitative selective capture law for the matrix diameter and particle diameter, which provides theoretical guidance for production practice.

New insights into selective flotation recovery of gold using dye-derived thermo-responsive polymeric surfactant: DFT calculation and adsorption mechanism

The selective flotation recovery of gold from secondary resources is a sustainable strategy to fill the ever-increasing demand for gold resources, and reduce the environmental pollution. In the present work, a novel method to realize the selective and fast recovery of Au(III) in the flotation process involving the use of thermo-responsive amphiphilic polymer poly(ethylene glycol)-b-poly(N-isopropylacrylamide-co-glycidyl methacrylate) (PEG113-b-P(NIPAM108-co-GMA62)) integrated with rhodamine B thiohydrazide (RBS) affinity ligand was studied. The polymer possessed the selective capture property toward Au(III) salt and excellent adsorption performance on bubble surfaces, driven by specific coordination interactions between Au(III) salt and RBS ligand, and hydrophobic interactions between GMA moieties and bubbles. Flotation using the thermo-responsive polymeric surfactant displayed a high separation efficiency and fast flotation kinetics, achieving a separation efficiency of 85% for Au(III) salt at 28 min, which was comparable with sulfur-functionalized mesoporous materials. This flotation process followed pseudo-second-order kinetics and Freundlich isotherm adsorption model. Furthermore, in flotation recovery of Au(III) salt form actual e-waste leaching solution, separation efficiency of 81% was achieved, while Au grade was improved from 1.55 % to 34.76%. This polymeric surfactant was easily regenerated by the reduction-induced release the bound Au(III) salt and thermal precipitation, leading to retain 81% of separation efficiency after five cycles. This work provides an effective way to fabricate flotation surfactant, which can meet the urgent demand for performance improvement and chemical consumption reduction in practical applications.

Construction of 2D metal-organic precursor networks with tunable porosity: A Monte Carlo simulation approach

Two-dimensional network structures comprising functional organic building blocks have been recently recognized as promising platforms for various physio-chemical processes running in confined spaces. In this study, we present theoretical results of the self-assembly of metal-organic precursor networks on a crystalline surface and provide quantitative characteristics of these planar architectures. To that end, a coarse-grained model of the adsorbed overlayer comprising halogenated polyaromatic aromatic hydrocarbon (PAH) molecules and bivalent metal atoms was used in combination with the equilibrium Monte Carlo (MC) simulation method. Our calculations focused on the effect of molecular features, such as size, shape and distribution of halogen substituents in the PAH monomer, on the quality and morphology of the networks formed on a model (111) crystalline surface. For the simulated porous assemblies, representing the precursor stage of the surface-assisted Ullmann coupling reaction, such descriptors as the unit cell parameters, radial distribution functions, pore size distributions and structure factors were determined. The obtained results demonstrated that fine-tuning of the monomeric PAH units enables the creation of periodic and aperiodic networks having diverse porous properties, ranging from monoporous to heteroporous with bi- and multimodal pore-size distributions. The findings of our theoretical investigations, apart from the potential application in the optimization of 2D polymeric networks, can also be helpful in designing real confined nanoenvironments for selective capture and immobilization/transformation of guest species.

Employing metal-organic cage for selective capture of UO22+ and Sr2+

Employing metal-organic cage for selective capture of UO22+ and Sr2+

Pristine Multi-walled carbon nanotubes for a rapid and efficient plasmid DNA clarification

Therapeutic approaches based on nucleic acids to modulate cell activity have recently gained attention. These molecules arise from complex biotechnological processes, requiring effective manufacturing strategies, high purity, and precise quality control to be used as biopharmaceuticals. One of the most critical and time-consuming steps for nucleic acids-based biotherapeutics manufacturing is their purification, mainly due to the complexity of the extracts. In this study, a simple, efficient, and reliable method to isolate and clarify plasmid DNA (pDNA) from complex samples is described. The method is based on the selective capture of RNA and other impurities, using pristine carbon nanotubes (CNTs). Multi-walled CNTs (MWCNTs) with different diameters were studied to determine their adsorption capacity and to address their ability to interact and distinguish between nucleic acids. The results revealed that MWCNTs preferentially interact with RNA and that smaller MWCNTs present a higher adsorption capacity, as expected by the higher specific surface area. Overall, this study showed that MWCNTs significantly reduce the levels of impurities, namely RNA, gDNA, and proteins, by approximately 83.6 % compared to their initial level, enabling the recovery of clarified pDNA in solution while maintaining its stability throughout the recovery process. This method facilitates the pre-purification of pDNA for therapeutic applications.

Surface Potential Modulation in Boronate-Functionalized Magnetic Nanoparticles Reveals Binding Interactions: Toward Magnetophoretic Capture/Quantitation of Sugars from Extracellular Matrix.

Phenylboronic acids (BAs) are important synthetic receptors that bind reversibly to cis-diols enabling their use in molecular sensing. When conjugated to magnetic iron oxide nanoparticles, BAs have potential for application in separations and enrichment. Realizing this will require a new understanding of their inherent binding modes and measurement of their binding capacity and their stability in/extractability from complex environments. In this work, 3-aminophenylboronic acid was functionalized to superparamagnetic iron oxide nanoparticles (MNPs, core diameter 8.9 nm) to provide stable aqueous suspensions of functionalized particles (BA-MNPs). The progress of sugar binding and its impact on BA-MNP colloidal stability were monitored through the pH-dependence of hydrodynamic size and zeta potential during incubation with a range of saccharides. This provided the first direct observation of boronate ionization pKa in grafted BA, which in the absence of sugar shifted to a slightly more basic pH than free BA. On exposure to sugar solutions under MNP-limiting conditions, pKa moved progressively to lower pH as maximum capacity was gradually attained. The pKa shift is shown to be greater for sugars with greater BA binding affinity, and on-particle sugar exchange effects were inferred. Colloidal dispersion of BA-MNPs after binding was shown for all sugars at all pHs studied, which enabled facile magnetic extraction of glucose from agarose and cultured extracellular matrix expanded in serum-free media. Bound glucose, quantified following magnetophoretic capture, was found to be proportional to the solution glucose content under glucose-limiting conditions expected for the application. The implications for the development of MNP-immobilized ligands for selective magnetic biomarker capture and quantitation from the extracellular environment are discussed.

Stepwise application of ECG and electrogram based criteria to ensure left bundle branch pacing

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): MPL received the Catalan Society of Cardiology Research Grant in 2019 and 2020 (Catalonia, Spain); the Josep Font Grant (2019-2022) from Hospital Clínic Barcelona (Catalonia, Spain). Background Left bundle branch pacing (LBBP) has emerged as an alternative to biventricular pacing. However, lack of a systematic stepwise application of the left bundle branch (LBB) capture criteria complicates implantation. Objective To define a stepwise application of LBBP capture criteria that will simplify implantation and ensure LBB capture. Methods A cohort of 24 patients from the LEVEL-AT trial who received LBBP and had electrocardiographic imaging (ECGI) at 45 days post-implant were included. The usefulness of ECG and electrogram based criteria to predict accurate LBB capture were analyzed. A two-step approach was developed to ensure LBB capture. The gold standard used to confirm LBB capture was the change in ventricular activation pattern and shortening in left ventricular activation time, assessed by ECGI. Results Twenty-two (91.6%) patients showed LBBP capture on ECGI. All patients fulfilled pre-screwing requisites: lead in septal position in left-oblique projection and W paced morphology in V1. In the first step, presence of either right bundle branch conduction delay pattern (qR or rSR in V1) or left bundle branch capture Plus (QRS ≤120ms) resulted in 95% sensitivity and 100% specificity to predict LBB capture, with an accuracy of 95.8%. In the second step, the presence of selective capture (100% specificity, only 41% sensitivity) or a spike-R<80ms (100% specificity, sensitivity 46%) ensured 100% accuracy to predict LBBP capture. Conclusions Stepwise application of ECG and electrogram criteria ensured an accurate assessment of left conduction system capture.

Rapid dissociation of high concentration excitons between [Bi2O2]2+ slabs with multifunctional N-Bi-O sites for selective photoconversion into CO

Regulation of exciton generation and dissociation, directed transfer to active center and oxidation capacity are the key steps in photoconversion. Here, we report that the multifunctional N-Bi-O sites are prepared in BiOBr nanosheets without the introduction of oxygen vacancy to reduce localized overreaction centers, which can not only enhance the Coulomb force between [Bi2O2]2+ slabs, thus increasing the exciton concentration, but also form low-oxidation-state active centers which can serve as the selective reaction sites and hole capture sites. Additionally, electronic fast recombination channels promote rapid dissociation of excitons and synergistic attraction to low-oxidation-state active centers to form weak holes. These holes prefer to rapid photoconversion of TC into CO instead of CO2. The yield of selective photoconversion into CO is 43.53 µmol/g, and the proportion of CO products is 16.21%. This work proposes a strategy for the cooperative construction of multifunctional active centers and multiexciton dissociation structures.

Isotope-coded derivatization with designed Girard-type reagent as charged isobaric mass tags for non-targeted profiling and discovery of natural aldehydes by liquid chromatography-tandem mass spectrometry

Aldehyde-containing metabolites are reactive electrophiles that have attracted extensive attention due to their widespread occurrence in organisms and natural foods. Herein we described a newly-designed Girard's reagent, 1-(4-hydrazinyl-4-oxobutyl)pyridin-1-ium bromide (HBP), as charged tandem mass (MS/MS) tags to facilitate selective capture, sensitive detection and semi-targeted discovery of aldehyde metabolites via hydrazone formation. After HBP labeling, the detection signals of the test aldehydes were increased by 21–2856 times, with the limits of detection were 2.5–7 nM. Upon isotope-coded derivatization with a pair of labeling reagents, HBP-d0 and its deuterium-labeled counterpart HBP-d5, the aldehyde analytes were converted to hydrazone derivatives, which generated characteristic neutral fragments of 79 Da and 84 Da, respectively. The isobaric HBP-d0/HBP-d5 labeling based LC-MS/MS method was validated by relative quantification of human urinary aldehydes (slope=0.999, R2 > 0.99, RSDs ≤ 8.5%) and discrimination analysis between diabetic and control samples. The unique isotopic doubles (Δm/z = 5 Da) by dual neutral loss scanning (dNLS) provided a generic reactivity-based screening strategy that allowed non-targeted profiling and identification of endogenous aldehydes even amidst noisy data. The LC-dNLS-MS/MS screening of cinnamon extracts led to finding 61 possible natural aldehydes and guided discovery of 10 previously undetected congeners in this medicinal plant.

Discriminatory Gate-Opening Effect in a Flexible Metal-Organic Framework for Inverse CO2 /C2 H2 Separation.

Considering the significant application of acetylene (C2 H2 ) in the manufacturing and petrochemical industries, the selective capture of impurity carbon dioxide (CO2 ) is a crucial task and an enduring challenge. Here, a flexible metal-organic framework (Zn-DPNA) accompanied by a conformation change of the Me2 NH2 + ions in the framework is reported. The solvate-free framework provides a stepped adsorption isotherm and large hysteresis for C2 H2 , but type-I adsorption for CO2 . Owing to their uptakes difference before gate-opening pressure, Zn-DPNA demonstrated favorable inverse CO2 /C2 H2 separation. According to molecular simulation, the higher adsorption enthalpy of CO2 (43.1kJmol-1 ) is due to strong electrostatic interactions with Me2 NH2 + ions, which lock the hydrogen-bond network and narrow pores. Furthermore, the density contours and electrostatic potential verifies the middle of the cage in the large pore favors C2 H2 and repels CO2 , leading to the expansion of the narrow pore and further diffusion of C2 H2 . These results provide a new strategy that optimizes the desired dynamic behavior for one-step purification of C2 H2 .

Effect of Functional Groups on Low-Concentration Carbon Dioxide Capture in UiO-66-Type Metal–Organic Frameworks

The selective capture of low-concentration CO2 from air or confined spaces remains a great challenge. In this study, various functional groups were introduced into UiO-66 to generate functionalized derivatives (UiO-66-R, R = NO2, NH2, OH, and CH3), aiming at significantly enhancing CO2 adsorption and separation efficiency. More significantly, UiO-66-NO2 and UiO-66-NH2 with high polarity exhibit exceptional CO2 affinity and optimal separation characteristics in mixed CO2/O2/N2 (1:21:78). In addition, the impressive stability of UiO-66-NO2 and UiO-66-NH2 endows them with excellent recycling stability. The effective adsorption and separation performances demonstrated by these two functional materials suggest their potential as promising physical adsorbents for capturing low-concentration CO2.

MOF-derived bimetallic coordination polymer@cobalt-aluminum layered double hydroxide for highly selective CO2 adsorption: Experiments, mechanisms

Selective capture of CO2 is one of the most effective strategies for combating the greenhouse effect. In this study, we report the synthesis of a novel adsorbent—an amine-based cobalt-aluminum layered hydroxide with a hafnium/titanium metal coordination polymer (denoted as Co-Al-LDH@Hf/Ti-MCP-AS)—through the derivatization of metal–organic frameworks (MOFs) for selective CO2 adsorption and separation. Co-Al-LDH@Hf/Ti-MCP-AS achieved the maximum CO2 adsorption capacity of 2.57 mmol g−1 at 25 °C and 0.1 MPa. The adsorption behavior followed the pseudo-second-order kinetics and Freundlich isotherm models, indicating that chemisorption occurs on a non-homogeneous surface. Co-Al-LDH@Hf/Ti-MCP-AS also exhibited selective CO2 adsorption in CO2/N2 and excellent stability over six adsorption–desorption cycles. An in-depth analysis of the adsorption mechanism through X-ray photoelectron spectroscopy and density-functional theory and frontier molecular orbital calculations revealed that adsorption occurs through acid–base interactions between amine functional groups and CO2 and that the tertiary amines (N3) have the highest affinity toward CO2. Our study provides a novel strategy for designing high-performance adsorbents for CO2 adsorption and separation.

Confined construction of CDs@MIL-101 as reusable and turn-on fluorescence sensor for highly sensitive water detection based on adsorption-solvent synergistic mechanism

Fabrication a reusable and highly sensitive fluorescence sensor in a controllable manner for water detection in solvents and humidity remains a top priority target yet a challenging task. In this work, carbon dots (CDs) are successfully implanted into confined metal–organic framework MIL-101(Cr) cages via “ship in the bottle” strategy and the confined CDs are firstly observed in MIL-101(Cr) cage showing high dispersion and high N content by advanced iDPC STEM technique. The highly selective water capture and sensitive changes of the fluorescence property with solution polarity and hydrogen-bonding donor acidity efficiently enhance the detection sensitivity and realize reusable turn-on detection based on the adsorption-solvent synergistic mechanism. Consequently, CDs@MIL-101 exhibits high sensitivity (detection limit: 0.036% and 0.028% v/v), wide response range (0.04–100% and 0.03–45%) and reusable stability for liquid water detection in acetone and tetrahydrofuran, respectively. Meanwhile, it can also detect gaseous water and the detection range is 23% to 85%. The analysis of real samples confirms the proposed method. Such construction strategy and detection mechanism will offer guidance for optimizing and expanding the detection performance of CDs, which is of great significance in the design and construction of novel multiphase sensors.