In order to evaluate the response of different genotypes of pinto bean (Phaseolus vulgaris L.) to water stress in field conditions three landraces of Shabestar, Maragheh and Zanjan along with two improved varieties of Talash and COS16 in Tabriz and Maragheh were studied. In field conditions genotypes were compared in three levels of water stress (once irrigation cut at 4-5 leaves stage, 50% flowering and 50% pod-forming stages) along with normal irrigation in two locations (Tabriz and Maragheh) with using from split plot design based on randomized complete block design (RCBD) with three replication. There was a significant difference between two locations in terms of biological yield, grain yield, number of pod per plant and harvest index. The difference of water stress levels was significant for all evaluated traits. It is noteworthy that different stress levels in two locations showed diverse responses. Also genotypes had significant difference in terms of all studied traits. The reaction of genotypes was different in two locations. Genotypes also had significant difference taking into account all traits. While the genotypes showed similar reaction to the different levels of water stress. However, genotype, stress and location interaction was significant for all traits. These results represented the location interaction with other under assessment factors. In the selection of tolerant genotypes to water stress with irrigation cut at three phonological stages COS16 and Talash improved cultivars in Maragheh and Tabriz had the best situation considering the most of drought tolerance indices, respectively.