Under the goal of "achieving carbon peak by 2030 and carbon neutrality by 2060", how to select the type of fresh air system has become a key area of energy conservation. The method of outdoor design PM2.5 concentration is one of the important factors affecting the selection of fresh air filtration system. This paper first analyzed the PM2.5 concentration values of 31 cities in China from 2017 to 2020 based on mathematical induction, and next gave the recommended coefficient K under six urban economic regions methods in combination with the actual situation. Finally, the selection of air filters in five typical cities was taken as an example, the differences in recommended coefficient K and selection of outdoor design PM2.5 concentration under different recommended methods were compared and analyzed. The results showed that the recommended coefficient K under the six economic regions could meet the required K value needs of the region. The recommended coefficient K by the six economic regions methods based on per capita GDP is the best. Under that conditions, the recommended coefficient K of the five typical cities under strict and normal conditions differs from the average K values of the six methods by 0.06 and 0.04. This paper will provide a new method for the correct selection of outdoor design PM2.5 concentration in fresh air systems to achieve the dual carbon energy-saving goal.