Aiming at the problem of site selection of rescue center under multi-objective after natural disaster, this paper constructs a site selection model to minimize the freight cost and maximize the time satisfaction of disaster victims. Firstly, the site selection model framework will be constructed according to the objectives, secondly, the model framework will be set up with specific constraints, and finally, the improved firefly optimization algorithm (SGSO) will be applied to conduct virtual simulation experiments. The SGSO algorithm is only used with the theory of the set of good points for the algorithm to initialize the population, and at the same time, it combines the inverse chord function with the step convergence factor, and it designs a formula for updating the position of the individuals in the population. On the basis of passing 8 standard test functions, virtual simulation experiments are carried out, and it is concluded that the SGSO algorithm can effectively solve the multi-objective siting problem, and provide more ideas and guarantees for the future research.