Background: Patient harm continues to be an essential concern in healthcare settings. Despite research, education, and collaborative efforts in patient safety, this issue remains a substantial problem and has yet to demonstrate a significant decrease in recent years. Purpose: Seeing as there is a dearth of available studies on this topic locally, the study intended to determine the relationship between patient safety climate (PSC), burnout, and safety outcome measures (SOM) among nurses employed at private tertiary level in Davao City, Philippines. Methods: The objective of this descriptive-correlational study was to establish a correlation between SOM, exhaustion, and PSC among nurses employed in private tertiary hospitals in Davao City. The snowball sampling method was utilized to select 197 respondents who met the following requirements: of legal age and currently employed as staff nurses in the study sites. The data were gathered using the Patient Safety Climate in Healthcare Organizations tool, Copenhagen Burnout Inventory, and Hospital Survey on Patient Safety Culture. Mean, standard deviation, Pearson r, and regression analysis were used in the statistical analysis. Results and Conclusions: The results showed that PSC (M=3.75, SD=0.89), burnout levels (M=3.44, SD=0.30), and SOM (M=3.81, SD=1.19) were high. PSC and SOM were significantly correlated (p=<.001; r=.280), whereas burnout and SOM (p=.843; r=.014) were not correlated. Patient safety climate (p=<.001; ÎČ=.280) was a predictor of safety outcome measures. Implications for Practice: Healthcare organizations are encouraged to cultivate a working environment where patient safety is recognized and prioritized. This will increase the frequency of event reporting, overall perceptions of safety, and patient safety grades.