BackgroundNeonatal seizures (NS) represent an important clinical manifestation among critically ill infants and are often the first sign of underlying brain injury. Early recognition and treatment are essential to reduce morbidity and mortality. ObjectiveThe present study investigated the NS management and treatment approaches employed by Level II/III neonatal intensive care units (NICUs) across the United States, to identify areas of consensus and variability. MethodsPersonnel associated with Level II/III NICUs were directly surveyed with an electronic questionnaire. Access to neurology specialists, on-site electroencephalography (EEG) monitoring and use of anti-seizure medications was directly queried. A total of 51 NICUs participated in this survey. Results25% of surveyed NICUs reported having an established clinical practice pathway available for treating neonatal seizures. 24% endorsed having written guidelines that provided a formal definition for the concept of “neonatal seizures.” Although the majority of NICUs reported having phenobarbital available for rapid seizure management, most NICUs lacked access to additional anti-seizure medications for treatment escalation. 24% of surveyed NICUs had no access to EEG monitoring available to them on-site. Daytime and overnight access to neurology consultants was limited and variable. ConclusionsFindings were consistent with a lack of equitable access for NS treatment. Areas of potential improvement include development and implementation of a protocol for rapidly treating neonatal seizures that emphasizes enhanced access to EEG and rapid neurology consultation, acknowledging and improving upon resource limitations. These developments may eventually provide earlier detection, evaluation, and treatment of seizures in newborns, contributing to improved long-term outcomes.