Cyclic natural progesterone therapy was added to the antiepileptic drug treatment of 25 women with intractable localization-related epilepsy and catamenial seizure exacerbation. At 3 months of treatment, the therapy was well tolerated in 23 women, and resulted in significantly improved seizure control in 18 women (72%) in comparison to baseline.1 In the 23 women who remained on therapy, complex partial seizures (CPS) declined by 54%; secondary generalized motor seizures (SGMS), by 58%.1 These 18 women continued on progesterone therapy. Fifteen did not change antiseizure medication. This Clinical Note presents the 3-year follow-up of this investigation. This study included 25 women between 18 and 40 years of age with clinically and electrographically documented intractable CPS or SGMS of temporal lobe origin. All women had epileptiform discharges in temporal lobe derivatives on EEG and …