Evaluating the seismic vulnerability of facades of historic masonry buildings is essential not only for their significant historical and heritage value, but also to evaluate the safety of this type of construction. This work applies a simplified methodology to assess the seismic vulnerability of the facade of masonry buildings in the historic center of Morelia, Michoacán, México. The historic center of Morelia was declared a World Cultural Heritage Site by UNESCO in 1991. On the facades, there is ornamentation with sculptural and vegetal decorative elements. The methodology involved conducting visual inspections to identify the location, type of structure, construction materials, doors, windows, balconies, cornices, ironwork, pediments, niches, and sculptures, among other characteristic elements of colonial architecture. The seismic demands were determined specifically for the city’s historic center based on a recent seismic hazard assessment of Morelia. Based on the methodology and the compiled database, characterized vulnerability indices were defined for the different damage scenarios that buildings may present. Results indicate that earthquakes with intensities greater than VIII on the Modified Mercalli scale risk collapsing heritage masonry buildings’ facades.