The complexity in nonlinear behavior of torsional-irregular buildings in combination with uncertainty due to the natural randomness of earthquake records has been always a main challenge for buildings’ seismic design. To find a solution to this challenge, three reinforced concrete (RC) building archetypes were designed and next developed into their nonlinear models. Nonlinear static (pushover) analyses were performed to calculate the capacity of the archetype models in all principal and non-principal directions while incremental dynamic analyses (IDAs) were conducted by applying 30 accelerograms from both near-field and far-field earthquakes. The IDA capacity curves, collapse fragility curves and log-normal cumulative distribution functions (CDFs) were established by including both the aleatory randomness and epistemic uncertainty. Despite previous studies wherein fragility curves were given by evaluating structures’ collapse along structural reference axes or simply on [Formula: see text], [Formula: see text]-axes, in this paper, possible building collapse on a critical non-principal direction (where maximum seismic response was observed) was simulated and its probability was accounted for developing IDA curves and log-normal CDFs. Accordingly, this issue was mirrored in computing available/acceptable collapse margin ratios (CMRs). In addition to the well-known outline used for calculating CMRs in the literature (that is based on estimation of collapse capacity in terms of earthquake intensity measure (IM)), the framework proposed here includes a new method for calculating the CMRs in terms of displacement-based drift, ductility, and damage. The superiority of the proposed method over the former is consistent with the buildings’ design procedure that is governed by storey drift control rather than base-shear strength. Refined statistics of CMRs given by taking into account displacement-based responses illustrate the available CMRs exceed the acceptable CMRs, meaning that a satisfactory safety margin against collapse will be anticipated in the targeted building class if a suitable yielding mechanism with sufficient ductility is provided for seismic force-resisting system by applying seismic design provisions of the current codes.