After an earthquake, it is necessary to understand its impact to provide relief and plan recovery. Social media (SM) and crowdsourcing platforms have recently become valuable tools for quickly collecting large amounts of first-hand data after a disaster. Earthquake-related studies propose using data mining and natural language processing (NLP) for damage detection and emergency response assessment. Using tex-data provided by the Euro-Mediterranean Seismological Centre (EMSC) collected through the LastQuake app for the Aegean Earthquake, we undertake a sentiment and topic analysis according to the intensities reported by their users in the Modified Mercalli Intensity (MMI) scale. There were collected 2,518 comments, reporting intensities from I to X being the most frequent intensity reported III. We use supervised classification according to a rule-set defined by authors and a two-tailed Pearson correlation to find statistical relationships between intensities reported in the MMI by LastQuake app users, polarities, and topics addressed in their comments. The most frequent word among comments was: “Felt.” The sentiment analysis (SA) indicates that the positive polarity prevails in the comments associated with the lowest intensities reported: (I-II), while the negative polarity in the comments is associated with higher intensities (III–VIII and X). The correlation analysis identifies a negative correlation between the increase in the reported MMI intensity and the comments with positive polarity. The most addressed topic in the comments from LastQuake app users was intensity, followed by seismic information, solidarity messages, emergency response, unrelated topics, building damages, tsunami effects, preparedness, and geotechnical effects. Intensities reported in the MMI are significantly and negatively correlated with the number of topics addressed in comments. Positive polarity decreases with the soar in the reported intensity in MMI demonstrated the validity of our first hypothesis, despite not finding a correlation with negative polarity. Instead, we could not prove that building damage, geotechnical effects, lifelines affected, and tsunami effects were topis addressed only in comments reporting the highest intensities in the MMI.