The seismic hazard in the Gujarat region has been evaluated. The scenario hazard maps showing the spatial distribution of various parameters like peak ground acceleration, characteristics site frequency and spectral acceleration for different periods have been presented. These parameters have been extracted from the simulated earthquake strong ground motions. The expected damage to buildings from future large earthquakes in Gujarat region has been estimated. It has been observed that the seismic hazard of Kachchh region is more in comparison with Saurashtra and mainland. All the cities of Kachchh can expect peak acceleration in excess of 500 cm/s2 at surface in case of future large earthquakes from major faults in Kachchh region. The cities of Saurashtra can expect accelerations of less than 200 cm/s2 at surface. The mainland Gujarat is having the lowest seismic hazard as compared with other two regions of Gujarat. The expected accelerations are less than 50 cm/s2 at most of the places. The single- and double-story buildings in Kachchh region are at highest risk as they can expect large accelerations corresponding to natural periods of such small structures. Such structures are relatively safe in mainland region. The buildings of 3–4 stories and tall structures that exist mostly in cities of Saurashtra and mainland can expect accelerations in excess of 100 cm/s2 during a large earthquake in Kachchh region. It has been found that a total of 0.11 million buildings in Rajkot taluka of Saurashtra are vulnerable to total damage. In Kachchh region, 0.37 million buildings are vulnerable. Most vulnerable talukas are Bhuj, Anjar, Rapar, Bhachau, and Mandvi in Kachchh district and Rajkot, Junagadh, Jamnagar, Surendernagar and Porbandar in Saurashtra. In mainland region, buildings in Bharuch taluka are more vulnerable due to proximity to active Narmada-Son geo-fracture. The scenario hazard maps presented in this study for moderate as well as large earthquakes in the region may be used to augment the information available in the probabilistic seismic hazard maps of the region.