On the 4th of September 1958, a sequence of 3 earthquakes of magnitude 6.7–6.9 struck the Andean Main Cordillera at the latitude of Santiago, Central Chile. The quakes were preceded by a magnitude 6.0 foreshock one week earlier. This seismic sequence provided the only documented effects of strong shaking related to shallow earthquakes in a subduction-zone environment in which seismicity is dominated by interplate and intermediate-depth intraplate earthquakes. The 1958 earthquake sequence is reviewed as part of a project of seismic hazard assessment of the densely populated region of Santiago. We reinterpret historical documents and carried out field observations to obtain new intensity estimates, and we estimate ranges of peak acceleration values based on geotechnical back-analyses of earthquake-induced landslides. Estimated peak intensities of 9 and peak accelerations close to 1 g illustrate the significant seismic hazard in areas around active faults in the region and the need to adapt the building codes to these rare but potentially highly destructive types of earthquakes.