International seismic codes stipulate that adjacent buildings should be separated by a specified minimum distance, otherwise the pounding effect should be considered in the design. Recent researches proposed an alternative method (Double Difference Combination Rule) to estimate seismic gap between structures, as this method considers the cross relation of adjacent buildings behavior during earthquakes. Four different criteria were used to calculate the minimum separation distance using this method and results are compared to the international codes for five separation cases. These cases used four case study buildings classified by different heights, lateral load resisting systems and fundamental periods of vibrations to assess the consistency in results for the alternative methods. Non-linear analysis was performed to calculate the inelastic displacements of the four buildings, and the results were used to evaluate the relation between elastic and inelastic displacements due to the ductility of structural elements resisting seismic loads. A verification analysis was conducted to guarantee that the separation distance calculated is sufficient to avoid pounding. Results shows that the use of two out of the four studied methods yields separation distances smaller than that calculated by the code specified equations without under-estimating the minimum separation distance required to avoid pounding.