The construction period of large structures such as hospitals can be prolonged due to complex construction processes. The behavior of frictional pendulum systems (FPSs) is strongly influenced by the seismic weight of the superstructure and the corresponding coefficient of friction. Therefore, the effects of the isolator behavior, which varies throughout the construction stages (CSs), on structural responses should be evaluated. Existing literature lacks adequate investigation into the behavior of isolated structures subjected to earthquakes during CSs. To address this gap, this paper investigates the structural performance of a base-isolated hospital building equipped with FPSs that experienced residual displacements during the February 6, 2023, Kahramanmaraş, Türkiye earthquakes (Mw 7.7 Pazarcık and Mw 7.6 Elbistan). At the time of the earthquakes, the building was still under construction (65–70 % complete). In addition to the hospital building under consideration, there were three more hospital buildings equipped with FPSs under construction during the 2023 Kahramanmaraş-Türkiye earthquakes in Türkiye. The seismic behavior and residual displacements of the structure during this CS were evaluated and numeric results were validated with real data measured in the field. Moreover, fragility analyses were performed for different CSs of the hospital building to reveal the probabilities of damage for base-isolated buildings exposed to earthquakes at various CSs. For fragility assessment, damage states (slight, moderate, extensive, collapse) were defined and four damage measures were chosen. Thus, the extent to which construction stages affected which types of damage was determined. A total of 1296 nonlinear time-history analysis were conducted to obtain fragility curves for all CSs and damage measures considering lower bound, nominal, and upper bound values of isolators. Selected isolated hospital building showed vulnerability in maximum top floor acceleration (MTFA) and maximum isolator displacement (MID) damage measures, but resilience in maximum roof drift ratio (MRDR) and maximum inter-story drift ratio (MIDR) damage measures. For the design basis earthquake (DBE) level, the probability of reaching the extensive damage state was 5.25 % for the MID, 11.39 % for MTFA, and 0 % for MIDR and MRDR. Similarly, for the maximum considered earthquake (MCE) level, these values were determined as 34.09 % for MID, 43.42 % for MTFA, and 0 % for MIDR and MRDR. The analysis revealed that while the probability of damage to the base isolation system was not related to CSs, residual displacements increased as construction progressed. Collapse thresholds for MIDR and MRDR demand exceptionally severe seismic events. As construction progresses, probabilities of exceeding damage states increase for MIDR and MRDR, indicating heightened vulnerability.