The brain's inflammatory response to stroke exacerbates ischemic damage 1. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced in brain 2 and exhibit anti-inflammatory properties 3. Mice with targeted deletion of soluble epoxide hydrolase (sEH), a key enzyme in EETs breakdown, are protected from ischemic brain injury 4. We tested the hypothesis that inflammatory cytokine expression after MCA occlusion is blunted in sEH knockout (sEHKO) mice due to higher brain EETs.