Summary It is objective of this study to investigate the potential role of different automatically derived quantitative parameters derived from velocity encoded MRI for the identification of asynchronic patients. Background About 30% of patients treated with cardiac resynchronization therapy (CRT) do not benefit from the procedure. Quantitative analysis of motion encoded MRI data may provide helpful parameters for the identification of CRT patients and prediction of the therapy outcome. Methods 11 Volunteers (30±8 years) and 3 patients (41±11 years) were investigated at a 3T whole body MR scanner (Achieva, Philips) with a 32 channel cardiac coil. The patients suffered from DCM, asynchrony and/or LBBB. A velocity encoded (TPM) navigated segmented gradient echo sequence was applied in the apical, equatorial and basal slice. The acquisition parameters were: FOV=340 2 mm 2 , in-plane resolution =2.5 2 mm 2 , slice thickness=8mm, acquisition matrix MxP=172x168, TR/ TE=6.3ms/4.6ms, a=15°, 3 k-lines per segment, VENC=30cm/s, nominal scan duration =5:51 minutes, black blood imaging with alternating presaturation pulses [1] and a SENSE acceleration factor of 2. For 60 bpm 32 cardiac phases were measured with a phase interval of 29.1ms. From the TPM data, the longitudinal and radial standard deviation of time to peak systolic and diastolic velocities SD(TTPl,sys), SD(TTPl,dias), SD(TTPr,sys), SD (TTPr,dias)over 6 segments [2], the radial, circumferential and longitudinal asynchrony correlation coefficient (ACC)[3], the longitudinal and radial velocity range Δvl =v l,max-vl,min, Δvr =v r,max-vr,min and the temporal uniformity of velocity (TUV) in radial, longitudinal and circumferential direction were derived. The latter one was defined in analogy to the temporal uniformity of strain [4,5].