A 68 y/o man was diagnosed huge pancreas head mass with suspicion of major vessels invasion. We might decide resection instead of chemoradiation therapy, because the effectiveness of neoadjuvant therapy was not supposed to be helpful in those setting. Based on those findings, we performed total pancreatectomy with splenectomy and segmental resection of transverse colon. Fortunately, there were no invasions of celiac axis with common hepatic artery grossly. However, tumor detachment from the major vessels was extremely demanding procedure. The patient had an uneventful recovery and he was discharged on postoperative day 42. From the specimen findings, undifferentiated malignant tumor which included the osteoclastic giant cells and showed positive for CK-AE1/3 and vimentin. The radial margin which was near the superior mesenteric artery had tumor cells suggesting R1 surgery.There were few data regarding R1 surgery about those tumors. Even though wide resection such as total pancreatectomy with adjacent organ resection was performed, pancreas head UC-OG abutted to major vessels had limitation of R0 resection. Currently, he is on gemcitabine based palliative chemotherapy for suspicion of peritoneal metastasis on 5 month after surgery and his general condition is comparably tolerable.