ABSTRACTLower Cretaceous early syn‐rift facies along the eastern flank of the Eastern Cordillera of Colombia, their provenance, and structural context, reveal the complex interactions between Cretaceous extension, spatio‐temporal trends in associated sedimentation, and subsequent inversion of the Cretaceous Guatiquía paleo‐rift. South of 4°30′N lat, early syn‐rift alluvial sequences in former extensional footwall areas were contemporaneous with fan‐delta deposits in shallow marine environments in adjacent hanging‐wall areas. In general, footwall erosion was more pronounced in the southern part of the paleorift. In contrast, early syn‐rift sequences in former footwall areas in the northern rift sectors mainly comprise shallow marine supratidal sabkha to intertidal strata, whereas hanging‐wall units display rapid transitions to open‐sea shales. In comparison with the southern paleo‐rift sector, fan‐delta deposits in the north are scarce, and provenance suggests negligible footwall erosion. The southern graben segment had longer, and less numerous normal faults, whereas the northern graben segment was characterized by shorter, rectilinear faults. To the east, the graben system was bounded by major basin‐margin faults with protracted activity and greater throw as compared with intrabasinal faults to the west. Intrabasinal structures grew through segment linkage and probably interacted kinematically with basin‐margin faults. Basin‐margin faults constitute a coherent fault system that was conditioned by pre‐existing basement fabrics. Structural mapping, analysis of present‐day topography, and balanced cross sections indicate that positive inversion of extensional structures was focused along basin‐bounding faults, whereas intrabasinal faults remained unaffected and were passively transported by motion along the basin‐bounding faults. Thus, zones of maximum subsidence in extension accommodated maximum elevation in contraction, and former topographic highs remained as elevated areas. This documents the role of basin‐bounding faults as multiphased, long‐lived features conditioned by basement discontinuities. Inversion of basin‐bounding faults was more efficient in the southern than in the northern graben segment, possibly documenting the inheritance and pivotal role of fault‐displacement gradients. Our observations highlight similarities between inversion features in orogenic belts and intra‐plate basins, emphasizing the importance of the observed phenomena as predictive tools in the spatiotemporal analysis of inversion histories in orogens, as well as in hydrocarbon and mineral deposits exploration.