Reservoir sedimentation reduces the gross storage capacity of dams and also negatively impacts turbine functioning, posing a danger to turbine inlets. When the sediment delta approaches the dam, further concerns arise regarding sediments passing through turbine intakes, blades abrasion due to increased silt/sand concentration, choking of outlets, and dam safety. Thus, slowing down the delta advance rate is a worthy goal from a dam manager’s viewpoint. These problems can be solved through a flexible reservoir operation strategy that prioritize sediment deposition further away from the dam face. As a case study, the Mangla Reservoir in Pakistan is selected to elaborate the operational strategy. The methodology rests upon usage of a 1D sediment transport model to quantify the impact of different reservoir operating strategies on sedimentation. Further, in order to assess the long-term effect of a changing climate, a global climate model under representative concentration pathways scenarios 4.5 and 8.5 for the 21st century is used. The reduction of uncertainty in the suspended sediments concentration is achieved by employing an artificial neural networking technique. Moreover, a sensitivity analysis focused on estimating the impact of various parameters on sediment transport modelling was conducted. The results show that a gradual increase in the reservoir minimum operating level slows down the delta movement rate and the bed level close to the dam. However, it may compromise the downstream irrigation demand during periods of high water demand. The findings may help the reservoir managers to improve the reservoir operation rules and ultimately support the objective of a sustainable reservoir use for the societal benefit.