ABSTRACT Spatio-temporal assessment of the evolution and morphodynamics of the Brahmaputra River (BR) can contribute significantly in mitigating challenges offered by rapid urbanisation and climate change. The present remote sensing and geographic information system (RS and GIS) based analysis of the BR revealed an increased Braiding Intensity (BI) from 1976 to 2000, which declined in 2010, and re-emerged in 2020. The average maximum width of the river has generally widened over time and sandbar distribution has exhibited fluctuations. The overall active channel area increased by 1.5 times, and the sandbar area expanded by 1.2 times between 1976 and 2020. The interplay between braiding intensity and width reveals a positive relationship. The sandbar-water ratio reveals a significant prevalence of sandbars in the Brahmaputra River. Furthermore, the study highlights changes in the Bar Development Index (BDI), showing a significant increase in micro-bars and meso-bars but a decrease in macro-bars. With the approach of change detection, key factors observed within the river driving the changes are erosion, channel bifurcations, sandbar formation due to sediment deposition, and sandbar loss due to shifts in channel course. These characteristics are potentially influenced by high water and sediment influx, climate change, and anthropological activities.