The evolution of Tethys is analysed on the basis of ophiolitic geology, reconstruction of continental margins, and plate kinematics. The North Anatolian-Minor Caucasian-South Caspian ophiolitic belt is considered to be the major suture of Palaeozoic Tethys, dividing its southern carbonate shelf from the Pontian-Caucasian-Turanian active margin. The Caucasian part of the latter comprises the Transcaucasian island arc, the Great Caucasian small ocean basin, the Great Caucasian island arc and the Precaucasian marginal sea, each characterised by its own magmatic, metamorphic and sedimentary facies association typical of that tectonic environments. The North Anatolian branch of Tethys persisted throughout the Palaeozoic and Mesozoic, whereas eastwards the major oceanic tract shifted south into the Zagros zone. The Northern frame of Mesotethys comprises the Pontain-Caucasian and Nakhichevan-Iranian island arc systems, divided by the Minor Caucasian basin, a relict of Palaeotethys reduced to a narrow northern branch of the Mesozoic ocean. In the late Cretacaous-Palaeogene, the youngest southwestern branch of Tethys separated Taurus-Anatolia from the Arabian shelf. Its ‘old’ northern branches were closed in the Palaeogene. Northward subduction in the South Anatolia-Zagros intracontinental basin triggered Neogene calc-alkaline volcanism in the Pontides, Antolia, Caucasus and Iran.