Recovering fine valuable material has been a significant challenge in minerals processing. This primarily stems from insufficient collision opportunities between fine particles and bubbles, specifically when utilising traditional recovery methods such as froth flotation. This research endeavours to address this challenge by exploring the use of various commercially available, high molecular weight polymers- specifically polyacrylamide (PAM)- to selectively aggregate hematite from quartz. Investigation of the conditions in which selective aggregation of hematite over quartz occurs, with the goal to achieve aggregate sizes of between 20 and 150 μm, were undertaken. Targeting this size range ensure that conditions are optimised for future use in conventional mechanical flotation cells as an efficient mineral recovery method. The study investigates the selectivity of charged PAM towards hematite and quartz at pH 10, using adsorption studies. Anionic PAM demonstrates a preference for hematite, with a range of charge density studies, highlighting stronger adsorption capacity with lower charge density polymers. Using BlazeMetrics probe technology for in-situ sizing and imaging, it was observed that conditioning 50–300 g APAM per t of hematite resulted in aggregates in the range of 30–230 μm after 5 min. Interestingly, the charge density of APAM does not markedly affect the size of the hematite aggregates, although altering the charge density of the polymer impacts the selectivity towards quartz. Additionally, cationic PAM results in the simultaneous aggregation of both hematite and quartz, not demonstrating selectivity. To mitigate heterocoagulation between minerals, a common dispersant, sodium hexametaphosphate (SHMP), was employed, which notably prevents quartz aggregation. Separation of aggregated hematite from quartz by sedimentation was only slightly effective with the majority of quartz settling with the hematite. Adding up to 1000 g of dispersant per t of hematite reduced the amount of quartz in the sediment bed by 23 %. The dispersant increased the magnitude of the negative zeta potential of the two minerals, particularly hematite, lowering heterocoagulation and improving effectiveness of hematite flocculation.