OBJECTIVES This study aimed to investigate the effects of regular aerobic exercise on cardiovascular health factors and heart function in sedentary male office workers.METHODS To achieve this aim, 20 individuals were selected as subjects: 10 in the exercise group (who have been regularly exercising for over 5 years, more than 4 times per week, for 1 hour or more per workout) and 10 in the control group (defines sedentary behavior more of moderate-intensity exercise for 30 minutes or longer, at least three days a week ). For data processing, the average and standard deviation were calculated using the SPSS 21.0 statistical program, and the difference in the mean value change between groups was verified by performing an independent t-test.RESULTS There were significant differences between groups in factors related to cardiovascular health, such as resting heart rate, maximum systolic blood pressure, maximum oxygen intake, and exercise duration. Regarding heart function, there were significant differences between both groups in peak velocities of early and atrial fillings, as well as in early and late diastolic annulus velocities.CONCLUSIONS Taken together, regular aerobic exercise appears to have a positive impact on cardiovascular health factors and heart function in sedentary male office workers.