Review question/objective The objective of this review is to assess the effectiveness of secondary school based HIV prevention interventions in South Africa. Due to the specific nature of the context and the specific targeting of secondary schools in South Africa, the review is focused only on secondary school interventions in South Africa. It is anticipated that these findings will inform the continuing development of policy and programmes in South Africa relevant to school based HIV intervention programmes. Inclusion criteria Types of participants This review will consider studies that include South African secondary school based male and female adolescents aged 12-19 years. Types of intervention(s)/phenomena of interest This review will consider studies that evaluate school based life skills interventions that focus on HIV prevention. Comparisons groups may include: usual school programme, other types of interventions such as TV, radio and print media campaigns. To avoid heterogeneity in interventions and outcomes, and due to the very specific nature of the structure in which the life skills programmes are offered, the review will be limited to those conducted in South Africa. Types of outcomes This review will consider studies that include the following outcome measures: HIV infections rate measured as age and gender specific prevalence Knowledge on HIV measured as changes in pre- and post-tests of knowledge and attitudes Condom usage measured as intention to use and reported use of condoms Any other relevant outcomes will be noted.