The ability to sinter the high-temperature superconducting ceramics (HTSC) used for making RF-SQUIDs, in which the conditions for observing secondary quantization effects (SQE) are satisfied, is discussed. The requirement for the ceramic sample characteristics, for example, granule size and type of intergrain junctions for minimizing the dielectric permeability and increasing the normal resistance of the weak link, are presented. It is shown that the method of preparing the YBa2Cu3O7−δ thick films by painting a (3BaCuO2+2CuO) mixture on a substrates of Y2BaCuO5 appears to be suitable. Experimental results show the possible influence of SQE on the signal characteristics of thick film YBa2Cu3O7−δ RF-SQUIDs.