Secondary Peak Research Articles

Pillar height regulated droplet impact dynamics on pillared superhydrophobic surfaces

Superhydrophobic surfaces that promote rapid droplet detachment have many significant engineering applications including self-cleaning, anti-icing, drag reduction. Adding macrotextures to superhydrophobic materials can markedly modify the dynamics of water impacting them, either by triggering a non-axisymmetric, center-assisted recoil or inducing pancake-like bouncing. However, the effect of pillar heights on superhydrophobic surfaces has received limited attention. Here, we have systematically investigated the role of the size ratio of pillar height-to-droplet radius (Q) on bouncing dynamics, including spreading, penetrating depth, contact time, bubble entrapment, impact pressure, and impact force, through numerical simulations. We show that droplet impact on superhydrophobic surfaces can generate two modes of bubble entrapment: one is an impinging cavity bubble, and the other is a recoiling cavity bubble, depending on Q. Furthermore, for low Weber number (We), droplet impacts may generate three peaks of impact force for superhydrophobic surfaces with high Q. For high We, only two peaks of impact force are generated during a droplet striking the superhydrophobic surface. However, the secondary peak in the impact force will weaken or may even disappear completely as Q increases, which was hitherto unknown. Interestingly, we also observe that despite lower impact force during droplet recoil compared to droplet impact, higher penetration depths are more easily achieved during the recoil stage. These findings shed light on the role of pillar heights in droplet impact dynamics, offering valuable insights for designing superhydrophobic surfaces.

UV damage induces production of mitochondrial DNA fragments with specific length profiles.

UV light is a potent mutagen that induces bulky DNA damage in the form of cyclobutane pyrimidine dimers (CPDs). Photodamage and other bulky lesions occurring in nuclear genomes can be repaired through nucleotide excision repair (NER), where incisions on both sides of a damaged site precede the removal of a single-stranded oligonucleotide containing the damage. Mitochondrial genomes (mtDNAs) are also susceptible to damage from UV light, but current evidence suggests that the only way to eliminate bulky mtDNA damage is through mtDNA degradation. Damage-containing oligonucleotides excised during NER can be captured with antidamage antibodies and sequenced (XR-seq) to produce high-resolution maps of active repair locations following UV exposure. We analyzed previously published datasets from Arabidopsis thaliana, Saccharomyces cerevisiae, and Drosophila melanogaster to identify reads originating from the mtDNA (and plastid genome in A. thaliana). In A. thaliana and S. cerevisiae, the mtDNA-mapping reads have unique length distributions compared to the nuclear-mapping reads. The dominant fragment size was 26 nt in S. cerevisiae and 28 nt in A. thaliana with distinct secondary peaks occurring in regular intervals. These reads also show a nonrandom distribution of di-pyrimidines (the substrate for CPD formation) with TT enrichment at positions 7-8 of the reads. Therefore, UV damage to mtDNA appears to result in production of DNA fragments of characteristic lengths and positions relative to the damaged location. The mechanisms producing these fragments are unclear, but we hypothesize that they result from a previously uncharacterized DNA degradation pathway or repair mechanism in mitochondria.

Determination of transient heat transfer by cooling channel in high-pressure die casting using inverse method

Complex shapes of aluminum castings are typically manufactured during the short cycle process known as the high-pressure die casting (HPDC). High productivity is ensured by introducing die cooling through a system of channels, die inserts or jet coolers. Die cooling can also effectively help in reducing internal porosity in cast components. Accurate simulations based on sophisticated numerical models require accurate input data such as material properties, initial and boundary conditions. Although the heat is dominantly dissipated through die cooling, indicating the importance of knowing precise thermal boundary conditions, open literature lacks a detailed information about the spatial distribution of heat transfer coefficient. This study presents an inverse method to determine accurate heat transfer coefficients of a die insert based on temperature measurements in multiple points by 0.5 mm K-type thermocouples and a subsequent solution of the two-dimensional inverse heat conduction problem. The solver was built in the open-source CFD code OpenFOAM and the free library for nonlinear optimization NLopt. The results are presented for the commonly used 10 mm die insert with a hemispherical tip and coolant flow rates ranging from 100 l/h to 200 l/h. Heat transfer coefficients reach values well above 50 kW/m2K in the hemispherical tip, which is followed by a secondary peak and then a gradual drop to values around 1 kW/m2K further downstream.

Non‐Geophysical Interhemispheric Asymmetries in Large Magnetic Field Residuals Between Swarm Observations and Earth Magnetic Field Models During Moderate to Quiet Geomagnetic Conditions

AbstractWe present a statistical study of large magnetic field vector residuals between Swarm observations and the 13th generation International Geomagnetic Reference Field (IGRF‐13) model under quiet to moderate geomagnetic conditions. Since the vast majority of data are taken during these conditions, statistics of these large residuals are important for satellite operation when using IGRF‐13 as reference, as well as for magnetosphere‐ionosphere‐thermosphere studies. Residuals with magnitude of vector differences between observations and model estimations larger than 300 nT under Dst > −50 nT are studied from 2014 to 2020. All large residuals appear in the high‐latitude auroral zone region peaking around 70° (−70°) magnetic latitude (MLAT) in the northern hemisphere (southern hemisphere) with also a secondary occurrence peak just below 80° (−80°) MLAT. However, the two hemispheres show clear asymmetries in the magnetic longitude and magnetic local time distribution where both hemispheres show high concentration of large residuals around the geographic poles. Since polar satellite's orbits give rise to highly biased number of observations around the geographic poles, it results in a decrease in occurrence rate with respect to the total number of measurements. We suggest that the asymmetries of large residuals in the two hemispheres around the geographic pole are not geophysical, but due to satellite orbit bias around the geographic poles and difference between IGRF and observations due to model error and geophysical processes not included in the model. Identifying these biases is helpful to better separate out geophysical electric current signatures from non‐geophysical ones.

Pore structure development of cementitious materials with manufactured sand from various lithologies and differential effect of CaO–MgO blend expansion agent

With intensifying the contradiction between the demand and supply of nature sand (NS), the extensive utilization of manufactured sand (MS) as a substitute has become prevalent in various projects. The pore structure development plays a crucial role in early-age shrinkage of concrete, but research on pore structure development of cementitious materials incorporating diverse lithologic MS is still lacking. This study examined the effects of MS powders and particles from diverse lithologies on pore structure, along with the differential impacts of CaO–MgO blend expansion agent (CMEA) on the pore structure of mortar containing MS from different lithologies. The results demonstrated a significant reduction in the peak value of pore size distribution and porosity in cement paste after incorporating MS powder, particularly with the most pronounced effect observed in tuff powder. In mortar, the incorporation of tuff manufactured sand (TMS) also led to a substantial decrease in both the peak value and peak area. However, the pore size distribution peak value and areas of limestone manufactured sand (LMS) mortar were slightly higher than those of NS mortar at 3 and 7 days. In comparison to cement pastes, the secondary peak proportion in mortars increased by approximately 4–5 percentage points at 28 days. Furthermore, the harmful pores and severely harmful exhibited varying degrees of increase in diverse lithologic MS mortar after incorporating CMEA, with the highest increase observed in NS mortar and the smallest increase observed in TMS mortar.

Epidemiological and etiological investigations of hand, foot, and mouth disease in Jiashan, northeastern Zhejiang Province, China, during 2016 to 2022.

Hand, foot, and mouth disease (HFMD) is a common infectious disease in children. Enterovirus A71 (EV71) and coxsackievirus A16 (CA16) have been identified as the predominant pathogens for several decades. In recent years, coxsackievirus A6 (CA6) and coxsackievirus A10 (CA10) have played increasingly important roles in a series of HFMD outbreaks. We performed a retrospective analysis of the epidemiology of HFMD and the spectrum of different viral serotypes, to elucidate the genetic and phylogenetic characteristics of the main serotypes in the Jiashan area during 2016 to 2022. Descriptive epidemiological methods were used to analyze the time and population distribution of HFMD in Jiashan during 2016 to 2022 based on surveillance data. Molecular diagnostic methods were performed to identify the viral serotypes and etiological characteristics of HFMD. Phylogenetic analyses was based on VP1 region of CA16 and CA6. The average annual incidence rate of HFMD fluctuated from 2016 to 2022. Children aged 1-5 years accounted for 81.65% of cases and boys were more frequently affected than girls. Except when HFMD was affected by the COVID-19 epidemic in 2020 and 2022, epidemics usually peak in June to July, followed by a small secondary peak from October to December and a decline in February. Urban areas had a high average incidence and rural areas had the lowest. Among 560 sample collected in Jiashan, 472 (84.29%) were positive for enterovirus. The most frequently identified serotypes were CA6 (296, 52.86%), CA16 (102, 18.21%), EV71 (16, 2.86%), CA10 (14, 2.50%) and other enteroviruses (44, 7.86%). There were 71 and 142 VP1 sequences from CA16 and CA6, respectively. Substitution of N218D, A220L and V251I was detected in CA16 and may have been related to viral infectivity. Phylogenetic analysis showed that CA16 could be assigned to two genogroups, B1a and B1b, while all the CA6 sequences belonged to the D3a genogroup. CA6 and CA16 were the two major serotypes of enteroviruses circulating in the Jiashan area during 2016 to 2022. Continuous and comprehensive surveillance for HFMD is needed to better understand and evaluate the prevalence and evolution of the associated pathogens.

Influence of temperature changes and vertically transported trace species on the structure of MLT region during major SSW events

Sudden stratospheric warming (SSW) events are large-scale dynamic phenomena which can significantly affect the circulation, temperature, and composition of different atmospheric layers. The circulation changes during these events induce variations in the atmospheric neutral and ion densities and cause the vertical transport of various trace species. The severity of effects induced by major SSW events in the mesosphere and lower thermosphere (MLT) region has received less attention than that in the lower atmosphere. The major influence of temperature and vertically transported trace species on the energetics, thermal and compositional structure of the MLT region has been investigated during two major SSW events with elevated stratopause. Variations in the nitric oxide volume emission rates (NO-VER), a measure of infrared radiative cooling by NO, are reported for the first time in the context of the dynamical changes during SSW events. This study investigates the role of temperature and NO variability on the energetics of the MLT region, particularly during the formation of elevated stratopause. The effects of supplemented NO density on the secondary ozone layer has also been investigated during these events, the anti-correlation between secondary ozone and NO does not conclude on the role of NO in the secondary ozone peak density variations. Notwithstanding the similarity in terms of defining characteristics, both SSW events impact the secondary ozone layer differently. In contrast to earlier studies, it is suggested that along with temperature, the availability of atomic oxygen is the major factor for the observed variation in secondary ozone during the SSW events.

Preflight Spectral Calibration of the Ozone Monitoring Suite-Nadir on FengYun 3F Satellite

The Ozone Monitoring Suite-Nadir (OMS-N) instrument is the first hyperspectral remote sensor in the ultraviolet band of China’s Fengyun series satellites. It can be used to detect several kinds of atmospheric constituents. This paper describes the prelaunch spectral calibration of the OMS-N onboard FengYun 3F. Several critical spectral parameters including the spectral resolution, spectral dispersion, and the instrument spectral response function were determined through laser-based measurements. A secondary peak of the instrument spectral response function from the short wavelength side of the ultraviolet band was found, and the possible influence on data applications was analyzed using a reference solar model and radiative transfer model. The results indicate that the spectral resolution and spectral accuracy of OMS-N meet the mission requirements. However, the asymmetries in the instrument spectral response function in the ultraviolet band were found near nadir rows, which are expressed as the “asymmetric central peak” and “secondary peak”. The analysis results show that if the influences of the instrument spectral response function “asymmetric central peak” and “secondary peak” in the ultraviolet band are ignored, they will bring an error as large as 5% at the center of the absorption line.

General investigations on the heat treatment and thermal fatigue behavior of an experimental hot work tool steel tailored for laser powder bed fusion

An experimental hot work tool steel with a leaner chemistry compared to the standard AISI-H13 grade, aimed at enhanced processability, was gas atomized and processed using laser powder bed fusion (L-PBF) to >99.8 % relative density. The lower carbon content (∼0.25 wt% vs. ∼0.4 wt% in H13) resulted in a softer as-built (AB), and quenched martensite (∼485 HV1 vs. 625 HV1 in H13), higher martensite-start temperature (∼360 °C vs. 280–320 °C), and about ∼18 % reduction in dilatation, ascribed to the volume expansive martensitic transformation. Charpy V-notch impact toughness in AB condition (>30 J) was higher than those reported for AB H13. These features account for the improved L-PBF processability. The tempering response in comparison with a wrought H13, was characterized by a larger precipitation of thermally stable Mo- and V-rich secondary hardening alloy carbides at the expense of the easy-to-coarsen Cr-rich ones, attributed to the higher Mo and lower Cr content in experimental alloy. The combination of lower C- and V-contents in experimental alloy, reduced the driving force for the precipitation of coarse vanadium rich carbides during austenitization, as confirmed by electron diffraction spectroscopy (EDS) and synchrotron X ray diffraction. This led to a stronger fine secondary hardening alloy carbide precipitation during tempering, and enhanced temper resistance. As elaborated by isochronal tempering, as well as tempering curves, reduction of the elements Si, and Cr shifted the secondary hardness peak to higher tempering temperatures. Consequently, tempering, and thermomechanical softening resistance was significantly enhanced in the new steel with a maximum hardness of ∼550 HV1 in over-tempered condition (i.e., slightly above secondary hardness peak). Thermal fatigue (TF) tests revealed a denser and finer TF crack network with a larger oxidation in experimental steel. Thereby, the TF crack penetration depth scaling with the local plastic yielding of the matrix was evidently shorter in the new steel compared with wrought H13, thanks to significantly improved hot hardness, thermal conductivity, and enhanced thermomechanical softening resistance. Finally, a proof of concept is demonstrated by processing a relatively large injection molding die (150 mm × 110 mm × 30 mm) with promising tensile and impact toughness properties after direct double tempering to 51 HRC, and 45 HRC hardness levels.

Study on the Influence of Moisture Content and Void Ratio on the Disintegration of Red Clay

Guilin is a famous karst area, and currently the view that the disintegration of red clay will cause soil cave collapse is increasingly recognized. In order to study the influence of the coupling effect of moisture content and void ratio on the disintegration of red clay, different moisture contents and void ratios of Guilin red clay were placed on a self-made disintegration apparatus to record the real-time disintegration amount and observe the disintegration phenomenon. Images of the structural characteristics of soil were obtained by a scanning electron microscope (SEM). Additionally, nuclear magnetic resonance (NMR) was applied to analyze the distribution of water in both natural and saturated states. The results show that the disintegration rate of red clay decreases as the initial moisture content increases, but increases with the increase of void ratio. Both moisture content and void ratio affect the structural characteristics of red clay. When the moisture content remains constant, the soil changes from a three-peak to a two-peak structure as the void ratio increases. The total area and secondary peak area of the T2 spectrum increase, while the starting T2 value of the main peak shifts to the right and the area decreases. Meanwhile, the starting T2 value of the secondary peak shifts to the right and the area increases. When the void ratio remains constant, the starting T2 value of the main peak gradually shifts to the left and the area decreases as the moisture content increases. However, the starting T2 value of the secondary peak shifts to the right and the area decreases or first decreases and then increases. The disintegration rate does not exhibit a significant relationship with either pore volume or macropore volume. The combined water saturation shows a bilinear relationship with both the moisture content and void ratio, where it increases as the initial moisture content increases, but decreases as the void ratio increases, with a correlation coefficient of 0.9929. The disintegration rate has an exponential relationship with the combined water saturation, and it decreases as the combined water saturation increases, with a correlation coefficient of 0.9934.

The freshwater discharge into the Adriatic Sea revisited

The present study reconstructs the river discharge climatology and its respective historical series for all rivers of the Adriatic Sea with averaged climatological daily river discharge above 1 m3s−1, to reach a better representation of the Adriatic rivers in hydrodynamic models and, consequently, to develop a more realistic freshwater balance in the different regions of the hydrographic basin. Based on the European Flood Awareness System (EFAS) data set, a careful method of identification and selection of the Adriatic rivers, followed by a rigorous assessment against observational data, was developed to evaluate the current state of the Adriatic river discharges and their respective trends throughout several climate indicators from 1991 to 2022. Observational data are limited to 85% of the identified rivers, totaling 98% of the overall freshwater input into the Adriatic Sea. The results confirm that the Shallow Northern Adriatic receives the largest freshwater inputs with a daily average exceeding 2,400 m3s−1, which amounts to 61% of the overall Adriatic discharges. Consequently, this region guides the freshwater seasonal cycle of the Adriatic Sea, which presents a well-defined pattern of two flood peaks in late autumn and late spring, separated by a minimum discharge period at mid-summer. From the Central to the Southern Adriatic subregions, the absence of snow-melting effects prevents the secondary flood peak during the spring, shaping the seasonal cycle of river discharges from a single flood peak in late autumn to a drought period in August. The 32 years of continuous river discharge data reveal a negligible trend in the overall Adriatic Sea but a negative trend for the last decade (2013–2022). This decadal decrease is driven by the extreme drought that drastically pounded the northern Adriatic in 2022.

Mechanical response and damage evolution of CF/PEEK‐reinforced Al metal‐composite hybrid structure at high strain rate

AbstractA CF/PEEK‐reinforced Al metal‐composite hybrid structure (CF/PEEK/Al) and CF/PEEK bar were subjected to high strain rate compression tests with a split Hopkinson pressure bar (SHPB). With the increase in strain rates, both CF/PEEK and CF/PEEK/Al showed the strain rate strengthening effect, and the microscopic fracture surface of CF/PEEK changes from rough to smooth. In the plastic rheological stage of stress–strain curve, CF/PEEK shows a plateau effect, while CF/PEEK/Al shows the strain weakening effect. When the strain rate exceeds 3800 s−1, the stress–strain curve exhibits a secondary wave peak. The peak values of the secondary peak in CF/PEEK/Al are larger than CF/PEEK. In terms of peak stress, yield stress, and specific energy absorption, CF/PEEK/Al outperforms CF/PEEK. Compared with other structures, the CF/PEEK/Al metal‐composite hybrid structure has certain advantages in terms of yield strength and yield strain. The finite element method (FEM) and DIC system were applied to observe the dynamic damage process in the compression impact test. It was found that in CF/PEEK/A1, the Al thin‐walled tube was damaged and cracked at the contact interface, and the inner CF/PEEK began to be damaged at the contact center with the input bar. And at 335 μs after contact began, the shear band ran through to the side of the samples.Highlights A CF/PEEK‐reinforced Al metal‐composite hybrid structure (CF/PEEK/Al) was proposed, which is superior to CF/PEEK. When the strain rate exceeds 3800 s−1, the stress–strain curves of CF/PEEK and CF/PEEK/Al exhibit a secondary wave peak. The peak values of the secondary peak in CF/PEEK/Al are larger than CF/PEEK. With the increase in strain rates, both CF/PEEK and CF/PEEK/Al showed the strain rate strengthening effect, and the microscopic fracture surface of CF/PEEK changes from rough to smooth. In CF/PEEK/A1, the Al thin‐walled tube was damaged and cracked at the contact interface, and the inner CF/PEEK began to be damaged at the contact center with the input bar. And at 335 μs after contact began, the shear band ran through to the side of the samples.

NuSTAR detection of a broad absorption line in IGR J06074+2205

BeXRB pulsar IGR J06074+2205 using NuSTAR observations. The temporal and spectral characteristics of the source are investigated. We detect coherent X-ray pulsations of the source and determine the spin period evolution. Using the current spin period data of the source, we show that the source is spinning down at 0.0202(2) sday−1. The pulse profiles are found to evolve with energy and luminosity. Another interesting feature of the source is that the pulse profiles are dual peaked. The dual-peaked pulse profile is characterized by a decreasing secondary peak amplitude with increasing energy. We also observed a proportionate increase in the primary peak amplitude as the energy increases. The pulse fraction exhibits an overall increasing trend with the energy. The X-ray continuum of the source indicates the existence of a characteristic absorption feature with a centroid energy ∼55 keV, which may be interpreted as a cyclotron line. We estimate the corresponding magnetic field strength to be ∼4.74×1012 G. A peculiar ‘10 keV’ absorption feature is observed in the X-ray spectra of the second observation. The luminosity measurements predict that the source may be accreting in the sub-critical regime.

Epidemiology and etiology of hand, foot, and mouth disease in Zhengzhou, China, from 2009 to 2021

BackgroundHand, foot, and mouth disease (HFMD) is a common childhood infectious disease caused by a variety of enteroviruses (EVs). To explore the epidemiological characteristics and etiology of HFMD in Zhengzhou, China, we conducted a systematic analysis of HFMD surveillance data from Zhengzhou Center for Disease Control and Prevention from January 2009 to December 2021 (https://wjw.zhengzhou.gov.cn/). MethodsSurveillance data were collected from Zhengzhou Center for Disease Control and Prevention from January 2009 to December 2021 (https://wjw.zhengzhou.gov.cn/). Cases were analyzed according to the time of onset, type of diagnosis, characteristics, viral serotype, and epidemiological trends. ResultsWe found that the primary causative agent responsible for the HFMD outbreaks in Zhengzhou was Enterovirus A71 (EVA-71) (48.56%) before 2014. After 2015, other EVs gradually became the dominant strains (57.68%). The data revealed that the HFMD epidemics in Zhengzhou displayed marked seasonality, with major peaks occurring from April to June, followed by secondary peaks from October to November, except in 2020. Both the severity and case-fatality ratio of HFMD decreased following the COVID-19 pandemic (severity ‰: 13.46 vs. 0.17; case-fatality ‰: 0.21 vs. 0, respectively). Most severe cases were observed in patients aged 1 year and below, accounting for 45.81%. ConclusionsOverall, the incidence rate of HFMD decreased in Zhengzhou following the introduction of the EVA-71 vaccine in 2016. However, it is crucial to acknowledge that HFMD prevalence continues to exhibit a distinct seasonal pattern and periodicity, and the occurrence of other EV infections poses a new challenge for children's health.

Kinetic analysis and dosimetric characteristics of the thermoluminescent glow curve of aquamarine (Be3Al2(SiO3)6:Fe)

Kinetic analysis of the thermoluminescent (TL) glow curve of aquamarine, a cyan variety of beryl (Be3Al2(SiO3)6), is reported. Samples were irradiated at room temperature using a90Sr/90Y β source at a rate of 0.10 Gy-1. Measurements made at 1 °C/s after irradiation from 1 to 100 Gy show a high intensity peak at 75 °C followed by three secondary peaks at 115, 189 and 302 °C respectively. The dose response of the high intensity peak (called the main peak) is linear within the first 20 Gy, but tends towards sub-linearity as the dose is close to 100 Gy. The signal decays with the time delay between irradiation and reading. It decays about 14% of its initial value, 600 s after irradiation. Reproducibility analysis shows that the material reproduces its response under identical experimental conditions with an uncertainty of 0.8% after 10 Gy beta dose irradiation. The kinetic analysis of the TL glow curve was carried out using the curve fitting method. The results show that the main peak follows first order kinetics, its activation energy is of the order of 1 eV and the frequency factor is between 1012 and 1014 s−1, while some secondary peaks follow general order kinetics.

Mechanical characteristics analysis of high dimensional vibration isolation systems based on high-static-low-dynamic stiffness technology

Large floating raft vibration isolation systems (FRVISs) based on high-static-low-dynamic stiffness (HSLDS) technology offer excellent low frequency vibration isolation performance with broad application prospects. However, the design process for these complex high-dimensional coupled nonlinear systems remains poorly developed, particularly when applied for ocean-going vessels that experience rolling and pitching motions. The present work addresses this issue by establishing a six-degree-of-freedom HSLDS vibration isolation model for FRVISs composed of eight isolators, and the model is applied to fully analyze the swing stability and multidimensional vibration isolation performance of these systems. The influence of nonlinearity on the mechanical properties of the vibration isolators is analyzed more clearly by assuming that each vibration isolator realizes nonlinear HSLDS characteristics in the z direction and linear characteristics in the x and y directions. The results demonstrate that the swing displacement responses of the system are greatly reduced under weak nonlinearity, which reflects the high static stiffness and high static stability characteristics of an HSLDS system. The multidimensional vibration isolation performance of the system is evaluated according to the impacts of nonlinearity, the installation height Hz of the isolators, and the relative position Dr of the two middle isolators. The results of analysis demonstrate that applying a value of Hz = 0 produces the best vibration isolation performance overall under strong nonlinearity by avoiding unnecessary secondary peaks in the force transmission rate under harmonic mechanical excitation and ensuring a maximum high-frequency vibration isolation effect. However, applying a weak nonlinearity is better than a strong nonlinearity if Hz is not zero. In contrast, Dr has little effect on the vibration isolation effect of the raft in the x, y, and z directions. Therefore, an equidistant installation with Dr = 0.5 would be considered ideal from the standpoint of installation stability.

A Reduced Complexity Acoustic-Based 3D DoA Estimation with Zero Cyclic Sum.

Accurate direction of arrival (DoA) estimation is paramount in various fields, from surveillance and security to spatial audio processing. This work introduces an innovative approach that refines the DoA estimation process and demonstrates its applicability in diverse and critical domains. We propose a two-stage method that capitalizes on the often-overlooked secondary peaks of the cross-correlation function by introducing a reduced complexity DoA estimation method. In the first stage, a low complexity cost function based on the zero cyclic sum (ZCS) condition is used to allow for an exhaustive search of all combinations of time delays between pairs of microphones, including primary peak and secondary peaks of each cross-correlation. For the second stage, only a subset of the time delay combinations with the lowest ZCS cost function need to be tested using a least-squares (LS) solution, which requires more computational effort. To showcase the versatility and effectiveness of our method, we apply it to the challenging acoustic-based drone DoA estimation scenario using an array of four microphones. Through rigorous experimentation with simulated and actual data, our research underscores the potential of our proposed DoA estimation method as an alternative for handling complex acoustic scenarios. The ZCS method demonstrates an accuracy of 89.4%±2.7%, whereas the ZCS with the LS method exhibits a notably higher accuracy of 94.0%±3.1%, showcasing the superior performance of the latter.

Spatiotemporal Variation and Causes of Typical Extreme Precipitation Events in Shandong Province over the Last 50 Years

In this study, based on hourly ERA5 reanalysis data from July to September, from 1971 to 2020, for Shandong Province, we used mathematical statistical analysis, the Mann–Kendall nonparametric statistical test, cluster analysis, and other methods to extract and analyze the spatiotemporal variation characteristics and causes of typical extreme precipitation events. The results indicated the following: (1) The total number and duration of precipitation events show a nonsignificant upward trend, while the average and extreme rainfall intensities show a nonsignificant downward trend. (2) Extreme precipitation events are primarily concentrated in Qingdao, Jinan, Heze, and Binzhou, with fewer events occurring in central Shandong Province. (3) Extreme precipitation events are classified into four types (namely, patterns I, II, III, and IV). Pattern I exhibits two rain peaks, with the primary rain peak occurring after the secondary rain peak. Similarly, pattern II also displays two rain peaks, with equivalent rainfall amounts for both peaks. In contrast, pattern III has multiple, evenly distributed rain peaks. Finally, pattern IV shows a rain peak during the first half of the precipitation event. Pattern I has the highest occurrence probability (46%), while pattern IV has the lowest (7%). (4) The spatial distributions of the different rain patterns are similar, with most being found in the eastern coastal and western regions. (5) Extreme precipitation events result from interactions between large-scale circulation configurations and mesoscale convective systems. The strong blocking situation and significant circulation transport at middle and low latitudes in East Asia, along with strong convergent uplift, abnormally high specific humidity, and high-water-vapor convergence centers, play crucial roles in supporting large-scale circulation systems and triggering mesoscale convective systems.

SPECTRA Phase 2b Study: Impact of Sotatercept on Exercise Tolerance and Right Ventricular Function in Pulmonary Arterial Hypertension.

This study aims to assess the impact of sotatercept on exercise tolerance, exercise capacity, and right ventricular function in pulmonary arterial hypertension. SPECTRA (Sotatercept Phase 2 Exploratory Clinical Trial in PAH) was a phase 2a, single-arm, open-label, multicenter exploratory study that evaluated the effects of sotatercept by invasive cardiopulmonary exercise testing in participants with pulmonary arterial hypertension and World Health Organization functional class III on combination background therapy. The primary end point was the change in peak oxygen uptake from baseline to week 24. Cardiac magnetic resonance imaging was performed to assess right ventricular function. Among the 21 participants completing 24 weeks of treatment, there was a significant improvement from baseline in peak oxygen uptake, with a mean change of 102.74 mL/min ([95% CIs, 27.72-177.76]; P=0.0097). Sotatercept demonstrated improvements in secondary end points, including resting and peak exercise hemodynamics, and 6-minute walk distance versus baseline measures. Cardiac magnetic resonance imaging showed improvements from baseline at week 24 in right ventricular function. The clinical efficacy and safety of sotatercept demonstrated in the SPECTRA study emphasize the potential of this therapy as a new treatment option for patients with pulmonary arterial hypertension. Improvements in right ventricular structure and function underscore the potential for sotatercept as a disease-modifying agent with reverse-remodeling capabilities. URL: https://www.clinicaltrials.gov; Unique identifier: NCT03738150.

Non-equilibrium thermal transport study in steady state GaN MISHEMT channel layer based on electron Monte Carlo and phonon BTE

An electro-thermal coupling simulator for GaN devices based on electron Monte Carlo (e-MC) simulations is established. Taking GaN Metal Insulator Semiconductor High Electron Mobility Transistor (MISHEMT) as example, the non-equilibrium thermal transport processes of self-heating effect in the channel layer are studied. This simulator is mainly coupled by e-MC and the phonon Boltzmann transport equation (pBTE), physical property parameters and electric field parameters are provided by first-principles and Technology Computer Aided Design (TCAD), respectively. We first verify the e-MC program by calculating the electron transport properties of GaN materials, verify the feasibility of the established GaN MISHEMT model by using TCAD and obtained its operating characteristics. Further, the simulator is used to evaluate the non-equilibrium processes inside the channel layer in detail, the results show that there is significant consistency in the peak positions of electric field strength, heat generation and diffusion temperature, the diffusion temperature peak occurs at the secondary peak of heat generation. The frequency distribution of phonon emission under different drain-source bias voltages is revealed by phonon emission spectrum analysis. The strength of the non-equilibrium effect is measured by effective temperature. Increasing the drain-source bias voltage will significantly increase the peak temperature of hotspot and further enhance the non-equilibrium effect. Our study reports an efficient scheme for electro-thermal simulations of GaN MISHEMT, which provides insights for thermal management of GaN-based transistor devices.