The article highlights the issues the International Classification of Functioning, which is being implemented worldwide to describe the functioning and limitations of human activity. The components are distinguished as follows: the functions and structures of the organism, activity, and participation―the performance of an action by an individual and his/her involvement in a life situation, as well as personal and environmental factors. In the Russian Federation, for the first time in a regulatory document (Order of the Ministry of Labor of Russia, dated August 27, 2019, N 585n), the International Classification of Functioning indicators were used to characterize persistent disorders of human functions.
 HIV infection is characterized by damage to the immune system with a decrease in the bodys resistance, which results in various diseases, such as secondary (opportunistic) infections and oncological, hematological, autoimmune, and lymphoproliferative diseases. A feature of HIV infection is the multiple organicity of lesions and the variety of clinical symptoms, which explains the diversity of impaired body functions reflected in the Order of the Ministry of Labor of Russia, in particular cardiovascular, respiratory, digestive, immune, endocrine, urinary system, neuromuscular, skeletal and movement-related (statodynamic), mental functions, blood, and metabolism disorders.
 The article highlights the issues of using the International Classification of Functioning in people with HIV infection or acquired immunodeficiency syndrome as a score to reflect the severity of persistent body disorders, particularly blood and immune system disorders, and the possibility for its use in people with disability.
 The paper presents a clinical example of a patient aged 34 years suffering from HIV infection, severe cellular immunodeficiency, complicated by pneumocystis pneumonia, candidiasis stomatitis, cheilitis, cachexia against the background of chronic viral hepatitis B and C, and poly-drug addiction with a second degree of dependence. The International Classification of Functioning in people with HIV infection or acquired immunodeficiency syndrome as a point assessment reflects the severity of persistent body disorders particularly blood and the immune system disorders and the possibility for its use in people with disabilities.