Variable inlet guide vanes (VIGVs) are most commonly used as the major control unit of integrally geared centrifugal compressors (IGCCs). In order to enhance the efficient operating range of the compressor, the loss mechanisms and utilization limits of state-of-the-art VIGVs need to be better understood. Field measurements in the wake of a typical, commercially used configuration were therefore conducted at the VIGV test facility of the Bundeswehr University Munich. The investigations were carried out at application oriented subsonic flow conditions and stagger angles from 50∘ to 90∘ covering the full low-loss operating range, including the limits of efficient operation. For a precise local loss characterization, an inflow correlation was developed and applied to consider total pressure inhomogeneities caused by the radial inflow velocity profile and minor circumferential velocity deviations. Contrary to previous research efforts, not only the profile losses, but also the secondary flow losses induced by the open blade tips and wall-blade interactions were resolved in full detail. For this reason, a more precise and comprehensive loss assessment of realistic VIGV cascades is acquired.