The aim of this study was to evaluate the clinical applications, graft uptake, and complications of split-thickness calvarial graft for the reconstruction of craniofacial defects.This retrospective study included 26 patients with craniofacial defects treated between January 2008 and December 2009. This included 17 male and 09 female patients between 9 and 45 years. Depending on the treatment provided, the patients were divided into 3 groups. Group 1 included 11 patients with cranial defect operated on for cranioplasty. Group 2 included 7 patients with orbital floor defect operated on for orbital floor reconstruction, and group 3 included 8 patients with alveolar cleft defect operated on for secondary alveolar grafting. Clinicoradiologic follow-up ranged from 18 to 24 months.In group 1, the symmetry of the calvarium was restored with good cosmesis. Improvement in neurologic function was observed in 7 patients. In group 2, the orbital volume and ocular function was maintained. In group 3, graft uptake was satisfactory with increase in bone density, and continuity of the alveolar bone was maintained. Cuspid eruption was aided orthodontically.Split calvarial grafts are suitable materials for craniofacial reconstruction. Their embryological origin, thickness, and shape are ideal for the restoration of craniomaxillofacial defects.