In this paper, we consider a class of second-order Hamiltonian system in $\mathbb {R}^{N}$ with combined nonlinearities. We will study the multiplicity of rotating periodic solutions, i.e., $x(t+T)=Qx(t)$ with $T>0$ and Q is an $N\times N$ orthogonal matrix. In the case $Q^{k}\neq I_{N}$ for any positive integer k, such a rotating periodic solution is just a quasi-periodic solution; In the case $Q^{k}=I_{N}$ for some positive integer k, such a rotating periodic solution is just a subharmonic solution. We will use the Fountain Theorem and its dual form to obtain two sequences of rotating periodic solutions with the corresponding energy tending to infinity and zero respectively.