The main purpose of this paper is to establish the existence, uniqueness and positive solution of a system of second-order boundary value problem with integral conditions. Using Banach’s fixed point theorem and the Leray-Schauder nonlinear alternative, we discuss the existence and uniqueness solution of this problem, and we apply Guo-Krasnoselskii’s fixed point theorem in cone to study the existence of positive solution. We also give some examples to illustrate our results.