Event Abstract Back to Event Gastroparesis disrupts normal gastric slow wave magnetic field patterns Alan Bradshaw1*, Chibuke Obioha1, Eric Chung1, Jon Erickson2 and Bill Richards3 1 Vanderbilt University, United States 2 Washington & Lee University, United States 3 University of South Alabama, United States The gastric slow wave (SW) originates along the greater curvature of the antrum with a frequency of about 3 cycles per minute (cpm) and propagates toward the pylorus. The electrogastrogram (EGG) is capable of measuring SW frequency, but recent studies have demonstrated that the magnetogastrogram (MGG) also reflects spatiotemporal properties of the SW. Gastroparesis causes slow gastric emptying, dyspepsia, nausea, early satiety, discomfort and intermittent vomiting. We compared MGG recordings from patients with diabetic gastroparesis (N=7) and normal controls (N=7) using the Tristan 637i SQUID gradiometer. We processed MGG signals with Second Order Blind Identification (SOBI) to identify the SW. We then reconstructed the MGG signal and compiled false-color spatiotemporal (ST) maps. By tracking the location of the maximum in these maps, we tracked the propagation of the SW and compared the patterns in maps from controls and patients. SW frequencies were similar for both patients (2.8±0.5 cpm) and controls (2.7±0.1 cpm), but standard deviations of the dominant frequency were substantially larger in patients. The percentage of power distributed (PPD) in normogastric (2-4 cpm) and tachygastric (4-9 cpm) ranges were significantly different between controls and patients, and a borderline significant difference was observed for bradygastric frequencies (1-2 cpm). Propagation patterns in ST maps showed dramatic differences between gastroparesis patients and normal controls, and several types of abnormal patterns were observed in patients, including rotational, static and retrograde propagation patterns in contrast to the anterograde patterns noted in controls. Propagation velocity was significantly different (8.3±0.6 mm/s anterograde in controls; -2.8±2.8 mm/s retrograde in patients) with substantially more variation noted in patients. We conclude that abnormal SW patterns in the MGGs of gastroparetic patients may indicate pathology better than frequency dynamics. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: Nanoparticles, Biosusceptometry and Effects of Magnetic Fields Citation: Bradshaw A, Obioha C, Chung E, Erickson J and Richards B (2010). Gastroparesis disrupts normal gastric slow wave magnetic field patterns. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00399 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Apr 2010; Published Online: 08 Apr 2010. * Correspondence: Alan Bradshaw, Vanderbilt University, Nashville, United States, alan.bradshaw@vanderbilt.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Alan Bradshaw Chibuke Obioha Eric Chung Jon Erickson Bill Richards Google Alan Bradshaw Chibuke Obioha Eric Chung Jon Erickson Bill Richards Google Scholar Alan Bradshaw Chibuke Obioha Eric Chung Jon Erickson Bill Richards PubMed Alan Bradshaw Chibuke Obioha Eric Chung Jon Erickson Bill Richards Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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