This paper aims to stretch the GPN approach through investigating a second-hand trade network. One of the understudied geographies of the world economy is the large-scale international trade in second-hand clothes which are exported from the Global North to Africa. Clothing collected by charities and commercial recyclers is sold in the developing world. This article examines how secondhand clothing commodities are produced in the UK, the international economic geographies of the used-clothing trade and labour activities in Mozambique. The societal, network and territorial embeddedness of GPNs are investigated illuminating how there are coordinated and non-integrated patterns of trade. Migrant and diaspora populations play key roles in coordinating activities between some exporters and importers, whereas in other networks British charities undertake the more profitable collection and sorting activities and are separated from African wholesale and retailers. Within global second-hand clothing networks there are different power relations between charities, firms and individuals, which enable them to extract more or less value from second-hand things. The socially and historically embedded roles of British charities and firms in the collection, sorting and export of second-hand clothing are discussed and the importance of the material culture which surrounds these networks of intersecting charitable and commercial activities are highlighted. The reproduction of exchange-value in used clothing through socially necessary labour time in sorting factories is examined. Different case studies are discussed demonstrating the difficulties of studying the complex webs of networks with dynamic geographies which constitute second-hand trade. This article stretches GPN analysis to consider the back-end of the global economy and explore how profit is accumulated from the trade in low-value commodities from the Global North to the Global South.